Somatic angiotensin-I-converting enzyme (sACE)

Definition:

Human somatic angiotensin-I-converting enzyme (sACE) comprises two homologous metallopeptidase domains, N and C, joined by an inter-domain linker. Both domains are capable of cleaving the two hemoregulatory peptides angiotensin I and bradykini. sACE is a key regulator of blood pressure and an important drug target for combating cardiovascular and renal disease.

References:

[1]. Hazel R Corradi, et al. Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design. J Mol Biol. 2006 Mar 31;357(3):964-74. [Content Brief]

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