Storkhead-box protein 1

Definition:

Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity).; [Isoform A]: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry. Induces phosphorylation of MAPT/tau.

References:

[1]. Daan van Abel, et al. Transcription factor STOX1A promotes mitotic entry by binding to the CCNB1 promotor. PLoS One. 2012;7(1):e29769. [Content Brief]

[2]. Daan van Abel, et al. STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease. Neurosci Lett. 2012 Oct 24;528(2):104-9. [Content Brief]

[3]. Ludivine Doridot, et al. Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene. Antioxid Redox Signal. 2014 Aug 20;21(6):819-34. [Content Brief]

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