Suppressor APC domain-containing protein 2

Definition:

Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2. Involved also in positive regulation of cell proliferation and tumor cell growth.

References:

[1]. Wei Sun, et al. Overexpression of p42.3 promotes cell growth and tumorigenicity in hepatocellular carcinoma. World J Gastroenterol. 2013 May 21;19(19):2913-20. [Content Brief]

[2]. Xiao-Sun Yuan, et al. p42.3: a promising biomarker for the progression and prognosis of human colorectal cancer. J Cancer Res Clin Oncol. 2013 Jul;139(7):1211-20. [Content Brief]

[3]. Catherine W N Chiu, et al. SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex. Dev Cell. 2016 Jan 11;36(1):50-62. [Content Brief]

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