T-box brain protein 1
Definition:
Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity).
References:
-
[1]. Pelagia Deriziotis, et al. De novo TBR1 mutations in sporadic autism disrupt protein functions. Nat Commun. 2014 Sep 18;5:4954. [Content Brief]
[2]. Joery den Hoed, et al. Functional characterization of TBR1 variants in neurodevelopmental disorder. Sci Rep. 2018 Sep 24;8(1):14279. [Content Brief]
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
