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TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Definition:

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1.; [Isoform 2]: May be an oncogenic factor.

References:

[1]. Tohru Ishitani, et al. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J. 2003 Dec 1;22(23):6277-88. [Content Brief]

[2]. Li Zhang, et al. Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Nature. 2011 Dec 11;481(7380):204-8. [Content Brief]

[3]. Ge Jin, et al. Identification of a human NF-kappaB-activating protein, TAB3. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2028-33. [Content Brief]

[4]. Atsuhiro Kanayama, et al. TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell. 2004 Aug 27;15(4):535-48. [Content Brief]

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