Transmembrane protein 266
Definition:
Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition.
References:
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[1]. Ferenc Papp, et al. TMEM266 is a functional voltage sensor regulated by extracellular Zn2. Elife. 2019 Feb 27;8:e42372. [Content Brief]
[2]. Iris H Kim, et al. Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1. PLoS One. 2014 Aug 28;9(8):e105926. [Content Brief]
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