Tripartite motif-containing protein 29
Definition:
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
References:
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[1]. Junji Xing, et al. TRIM29 promotes DNA virus infections by inhibiting innate immune response. Nat Commun. 2017 Oct 16;8(1):945. [Content Brief]
[2]. Junji Xing, et al. Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract. Nat Immunol. 2016 Dec;17(12):1373-1380. [Content Brief]
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