U1 small nuclear ribonucleoprotein 70 kDa

Definition:

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA.; [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.; [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.

References:

[1]. Daniel A Pomeranz Krummel, et al. Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution. Nature. 2009 Mar 26;458(7237):475-80. [Content Brief]

[2]. C C Query, et al. A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. Cell. 1989 Apr 7;57(1):89-101. [Content Brief]

[3]. Yasushi Kondo, et al. Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition. Elife. 2015 Jan 2;4:e04986. [Content Brief]

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