Ubiquitin-associated protein 2
Definition:
Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage. May promote the degradation of ANXA2.
References:
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[1]. Anna E Herlihy, et al. UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1. DNA Repair (Amst). 2022 Jul;115:103343. [Content Brief]
[2]. Dou-Sheng Bai, et al. UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2. Oncotarget. 2016 May 31;7(22):32946-55. [Content Brief]
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