Uropathogenic Escherichia coli (UPEC) infection

Definition:

Uropathogenic Escherichia coli (UPEC) infection is a prevalent infectious disease with potentially severe complications. UPEC, the most common etiological agent of community-acquired urinary tract infections (UTIs), accounts for >80% of UTI infections worldwide. Once inside the urinary tract, UPEC preferentially colonizes the bladder and causes cystitis, but can also ascend through the ureters into the kidneys, causing pyelonephritis.

References:

[1]. B K Dhakal, et al. Mechanisms and consequences of bladder cell invasion by uropathogenic Escherichia coli. Eur J Clin Invest. 2008 Oct;38 Suppl 2:2-11. [Content Brief]

[2]. Catharina Svanborg, et al. Uropathogenic Escherichia coli as a model of host-parasite interaction. Curr Opin Microbiol. 2006 Feb;9(1):33-9. [Content Brief]

[3]. Shingo Yamamoto, et al. Molecular epidemiology of uropathogenic Escherichia coli. J Infect Chemother. 2007 Apr;13(2):68-73. [Content Brief]

[4]. T Matsumoto, et al. [Virulence factors and host responses in urinary tract infections]. J UOEH. 1998 Mar 1;20(1):45-60. [Content Brief]

[5]. Travis J Wiles, et al. Origins and virulence mechanisms of uropathogenic Escherichia coli. Exp Mol Pathol. 2008 Aug;85(1):11-9. [Content Brief]

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