Voltage-dependent calcium channel subunit alpha-2/delta-2

Definition:

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.

References:

[1]. Simon Edvardson, et al. Early infantile epileptic encephalopathy associated with a high voltage gated calcium channelopathy. J Med Genet. 2013 Feb;50(2):118-23. [Content Brief]

[2]. Lubica Lacinová, et al. Modulation of gating currents of the Ca(v)3.1 calcium channel by alpha 2 delta 2 and gamma 5 subunits. Arch Biochem Biophys. 2004 May 15;425(2):207-13. [Content Brief]

[3]. Giovanni L Carboni, et al. CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity. Oncogene. 2003 Jan 30;22(4):615-26. [Content Brief]

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