Zinc finger protein 263

Definition:

Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor. Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression. Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions.

References:

[1]. Zhibin Yu, et al. The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically. Oncogene. 2020 Apr;39(15):3163-3178. [Content Brief]

[2]. Ryan J Weiss, et al. ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9311-9317. [Content Brief]

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