Zinc finger protein ubi-d4

Definition:

Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells. Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway.

References:

[1]. Xiaozhe Xiong, et al. Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2. Nat Chem Biol. 2016 Dec;12(12):1111-1118. [Content Brief]

[2]. Ferdinand M Huber, et al. Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6016-6021. [Content Brief]

[3]. Toshio Tando, et al. Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway. J Biol Chem. 2010 Jul 16;285(29):21951-60. [Content Brief]

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