Zona pellucida sperm-binding protein 2

Definition:

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.

References:

[1]. Can Dai, et al. ZP2 pathogenic variants cause in vitro fertilization failure and female infertility. Genet Med. 2019 Feb;21(2):431-440. [Content Brief]

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