ATP trisodium
Based on 164 publication(s) in Google Scholar
ATP (Adenosine 5'-triphosphate) trisodium is a central component of energy storage and metabolism in vivo. ATP trisodium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP trisodium is an important endogenous signaling molecule in immunity and inflammation. ATP trisodium can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP trisodium has anti-bacterial infection effects and can protect mice against bacterial infection in mice.
For research use only. We do not sell to patients.
- CAS No.: 20978-32-9
- Formula: C10H13N5Na3O13P3
- Molecular Weight:573.13
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) ATP trisodium
More- Signal Transduct Target Ther. 2026 Mar 12;11(1):90. [Abstract]
- Cell. 2025 Dec 11;188(25):7194-7205.e10. [Abstract]
- Cell. 2025 Jul 24;188(15):4025-4042.e20. [Abstract]
- Cell. 2025 Jul 10;188(14):3744-3756.e16. [Abstract]
- Cell Metab. 2026 Jul 7;38(7):1367-1384.e9. [Abstract]
- Cell Metab. 2026 May 14:S1550-4131(26)00151-8. [Abstract]
- Cell Res. 2025 Feb;35(2):97-116. [Abstract]
- Immunity. 2025 Sep 9;58(9):2320-2335.e9. [Abstract]
- Immunity. 2024 Mar 12;57(3):495-512.e11. [Abstract]
- Nat Biomed Eng. 2026 Jan 7.
- Cancer Res. 2025 Jul 25. [Abstract]
- Autophagy. 2026 Jun 12:1-18. [Abstract]
- Autophagy. 2026 Jun 25:1-16. [Abstract]
- Autophagy. 2026 May 25. [Abstract]
- Autophagy. 2026 May 17:1-21. [Abstract]
- Autophagy. 2025 Sep;21(9):1927-1944. [Abstract]
- Autophagy. 2025 Aug 16. [Abstract]
- Protein Cell. 2022 Apr;13(4):281-301. [Abstract]
- ACS Nano. 2023 Dec 12;17(23):23872-23888. [Abstract]
- J Adv Res. 2026 May 20:S2090-1232(26)00426-1. [Abstract]
- J Adv Res. 2026 Mar 12:S2090-1232(26)00239-0. [Abstract]
- Redox Biol. 2026 Jun 11:95:104255. [Abstract]
- Mol Cell. 2026 Jan 8;86(1):150-165.e9. [Abstract]
- Mol Cell. 2023 Jun 15;83(12):2137-2147.e4. [Abstract]
- Mol Cell. 2022 Jun 2;82(11):2032-2049.e7. [Abstract]
- Acta Pharm Sin B. 2026 Mar 10.
- Adv Sci (Weinh). 2026 Jun 12:e23688. [Abstract]
- Adv Sci (Weinh). 2025 Nov 11:e08957. [Abstract]
- Adv Sci (Weinh). 2025 Sep 26:e08991. [Abstract]
- Adv Sci (Weinh). 2025 Aug;12(31):e01532. [Abstract]
- Cell Rep Med. 2026 Jun 16;7(6):102842. [Abstract]
- Cell Death Differ. 2025 Nov 10. [Abstract]
- Cell Death Differ. 2022 Feb;29(2):439-450. [Abstract]
- Carbohydr Polym. 2020 Jun 1:237:116163. [Abstract]
- Pharmacol Res. 2026 Jul:229:108257. [Abstract]
- Cell Death Dis. 2022 Oct 8;13(10):860. [Abstract]
- Cell Death Dis. 2021 Dec 14;12(12):1159. [Abstract]
- Cell Death Dis. 2020 Feb 18;11(2):132. [Abstract]
- Cancer Lett. 2024 Oct 1:601:217145. [Abstract]
- Biosens Bioelectron. 2021 Apr 15:178:113025. [Abstract]
- Cell Commun Signal. 2025 Jul 8;23(1):327. [Abstract]
- Crit Care. 2021 Oct 12;25(1):356. [Abstract]
- Phytomedicine. 2026 Jan 16:153:157839. [Abstract]
- Phytomedicine. 2025 Dec:149:157563. [Abstract]
- Phytomedicine. 2025 Jul:142:156698. [Abstract]
- Phytomedicine. 2024 Jan:123:155193. [Abstract]
- Phytomedicine. 2023 Sep:118:154971. [Abstract]
- Burns Trauma. 2026 Jan 6.
- Mater Today Bio. 2025 May 10:32:101838. [Abstract]
- Mater Today Bio. 2025 Feb 1:31:101539. [Abstract]
- ACS Sens. 2026 Mar 27;11(3):1891-1907. [Abstract]
- J Hazard Mater. 2026 Jan 1:501:140687. [Abstract]
- Acta Pharmacol Sin. 2025 Jul 17. [Abstract]
- Acta Pharmacol Sin. 2025 Apr 7. [Abstract]
- Acta Pharmacol Sin. 2022 Aug;43(8):2016-2025. [Abstract]
- J Orthop Translat. 2026 Jan 6.
- J Transl Med. 2024 Sep 27;22(1):871. [Abstract]
- Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2424906122. [Abstract]
- Int J Biol Macromol. 2026 May:361:151905. [Abstract]
- Int J Biol Macromol. 2025 Dec 30;339(Pt 2):149976. [Abstract]
- Int J Biol Macromol. 2024 Apr 27;268(Pt 2):131779. [Abstract]
- EMBO J. 2025 Aug 18. [Abstract]
- Mol Med. 2025 Jun 16;31(1):240. [Abstract]
- Antioxidants (Basel). 2023 Jun 19;12(6):1304. [Abstract]
- Antioxidants (Basel). 2022 Nov 23;11(12):2315. [Abstract]
- Free Radic Biol Med. 2026 Aug 16:252:493-508. [Abstract]
- Free Radic Biol Med. 2025 Dec 22:245:98-114. [Abstract]
- Stem Cell Res Ther. 2025 May 1;16(1):222. [Abstract]
- Am J Chin Med. 2025;53(2):501-522. [Abstract]
- Cell Rep. 2025 Nov 25;44(12):116620. [Abstract]
- Cell Rep. 2025 Jan 10;44(1):115203. [Abstract]
- Cell Rep. 2024 Jun 27;43(7):114402. [Abstract]
- Cell Rep. 2021 Aug 10;36(6):109516. [Abstract]
- Cell Prolif. 2023 Sep;56(9):e13442. [Abstract]
- Br J Pharmacol. 2025 May 13. [Abstract]
- J Med Chem. 2026 Apr 9;69(7):7663-7676. [Abstract]
- Anal Chem. 2025 May 13;97(18):9827-9835. [Abstract]
- Cancer Cell Int. 2023 May 9;23(1):87. [Abstract]
- J Ethnopharmacol. 2026 May 10:362:121370. [Abstract]
- J Ethnopharmacol. 2026 Mar 25:359:121046. [Abstract]
- J Ethnopharmacol. 2025 Jul 30;353(Pt A):120346. [Abstract]
- J Ethnopharmacol. 2024 Jun 28:328:118057. [Abstract]
- J Ethnopharmacol. 2024 Feb 10:320:117388. [Abstract]
- Eur J Med Chem. 2026 May 5:309:118765. [Abstract]
- J Agric Food Chem. 2024 Sep 25;72(38):20959-20973. [Abstract]
- Biochem Pharmacol. 2026 Feb:244:117614. [Abstract]
- Biochem Pharmacol. 2025 Apr:234:116801. [Abstract]
- Biochem Pharmacol. 2024 Aug:226:116377. [Abstract]
- Life Sci. 2021 Apr 15:271:119192. [Abstract]
- Food Funct. 2025 Jun 16;16(12):4731-4753. [Abstract]
- Transl Res. 2023 May:255:1-13. [Abstract]
- Anal Chim Acta. 2021 Dec 15:1188:339180. [Abstract]
- Nutrients. 2021 Dec 14;13(12):4462. [Abstract]
- Eur J Pharmacol. 2026 Mar 28:1019:178738. [Abstract]
- Respir Res. 2024 Jul 30;25(1):291. [Abstract]
- Eur J Pharmacol. 2023 May 15:947:175681. [Abstract]
- Eur J Pharmacol. 2022 Feb 5:916:174729. [Abstract]
- Int Immunopharmacol. 2026 Aug 1:182:116787. [Abstract]
- Int J Mol Sci. 2026 May 12;27(10):4317. [Abstract]
- Int Immunopharmacol. 2025 Dec 10:167:115697. [Abstract]
- Int Immunopharmacol. 2025 Sep 5:165:115437. [Abstract]
- Int Immunopharmacol. 2025 Feb 20:148:114057. [Abstract]
- Int Immunopharmacol. 2024 Nov 2;143(Pt 3):113527. [Abstract]
- Int J Mol Sci. 2024 Sep 26;25(19):10366. [Abstract]
- Int Immunopharmacol. 2023 Mar:116:109747. [Abstract]
- Neurochem Int. 2025 Jul:187:105992. [Abstract]
- Inflammation. 2025 Dec 20;49(1):11. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166895. [Abstract]
- Sci Rep. 2026 Jun 11. [Abstract]
- Exp Neurol. 2026 Feb:396:115537. [Abstract]
- J Cell Mol Med. 2025 Jan;29(2):e70338. [Abstract]
- Appl Microbiol Biotechnol. 2024 Jan 25;108(1):173. [Abstract]
- J Inflamm Res. 2025 Jul 19:18:9587-9608. [Abstract]
- Structure. 2025 May 1;33(5):903-915.e5. [Abstract]
- Biochim Biophys Acta Mol Cell Res. 2024 Mar 22;1871(4):119712. [Abstract]
- Biochim Biophys Acta Mol Cell Res. 2024 Jan;1871(1):119595. [Abstract]
- FEBS J. 2026 Mar 10. [Abstract]
- Immunotargets Ther. 2024 Dec 14:13:775-788. [Abstract]
- J Virol. 2023 Mar 30;97(3):e0000323. [Abstract]
- Front Neurosci. 2022 Jun 7;16:901688. [Abstract]
- J Funct Foods. 2026 May 30;142:107364.
- Reprod Biomed Online. 2024 Oct;49(4):104319. [Abstract]
- Neuromolecular Med. 2023 Jun;25(2):230-241. [Abstract]
- Mol Immunol. 2024 May:169:86-98. [Abstract]
- J Dent Sci. 2025 Jul;20(3):1422-1435. [Abstract]
- Clin Oral Investig. 2023 Jun;27(6):2875-2885. [Abstract]
- Immun Inflamm Dis. 2026 Apr;14(4):e70434. [Abstract]
- Int J Biochem Cell Biol. 2026 Jan:190:106880. [Abstract]
- Bioorg Med Chem. 2021 Jan 1:29:115899. [Abstract]
- Hypertens Pregnancy. 2026 Dec 31;45(1):2609374. [Abstract]
- J Fluoresc. 2026 Jun;36(6):3899-3908. [Abstract]
- Mol Biol Rep. 2026 Jan 3;53(1):250. [Abstract]
- Placenta. 2025 May 22:167:204-215. [Abstract]
- Oral Dis. 2021 Jul;27(5):1148-1160. [Abstract]
- Vet Microbiol. 2025 Aug:307:110628. [Abstract]
- Vet Sci. 2024 Dec 12;11(12):643. [Abstract]
- Biochemistry. 2023 Dec 5;62(23):3396-3410. [Abstract]
- Biochem Biophys Res Commun. 2024 May 14:708:149814. [Abstract]
- Arch Oral Biol. 2019 Nov:107:104514. [Abstract]
- Cytotechnology. 2025 Apr;77(2):66. [Abstract]
- Cardiovasc Pathol. 2025 Nov-Dec:79:107750. [Abstract]
- Int J Dev Neurosci. 2023 Feb;83(1):53-66. [Abstract]
- Andrologia. 2026 May 25;2026(1):5522224.
- SSRN. 2026 Jun 3.
- bioRxiv. 2026 Jan 13.
- Biomed Pharmacother. 2025 Dec:193:118748. [Abstract]
- Brain Mechanisms. 2025 Nov 21.
- Biomed Pharmacother. 2025 Aug:189:118275. [Abstract]
- Res Sq. 2024 Sep 22.
- SSRN. 2024 Nov 19.
- Heliyon. 2024 Sep 19;10(19):e38050. [Abstract]
- Biomed Pharmacother. 2024 Aug:177:117111. [Abstract]
- Biomed Pharmacother. 2024 Aug:177:116952. [Abstract]
- Biomed Pharmacother. 2024 Aug:177:117006. [Abstract]
- Research Square Preprint. 2024 Apr 9.
- bioRxiv. 2024 Apr 21.
- Research Square Preprint. 2023 Sep 8.
- SSRN. 2023 May 12.
- SSRN. 6 Dec 2022.
- Research Square Preprint. 2022 May.
- Research Square Preprint. 2022 Feb.
- Aging (Albany NY). 2021 Sep 28;13(18):22588-22610. [Abstract]
- Research Square Preprint. 2021 Jul.
- Aging (Albany NY). 2021 Mar 10;13(6):8588-8598. [Abstract]
Customer Validation & Images
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RT-PCR
All Endogenous Metabolite Isoforms
More
Biological Activity
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NLRP3 inflammasome |
IL-1β |
ATP (5 mM; 1 hour) trisodium co-treatment with LPS (HY-D1056) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP trisodium (2 mM; 0.5-24 hours) trisodium induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4].
ATP trisodium (2mM) trisodium promotes neutrophil chemotaxis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Four-week-old Kunming mice infected with E. coli and S. aureus (18-22 g)[4]
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Dosage:50 mg/kg
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Administration:Intraperitoneal injection, 1, 4, 24 h before bacterial (E. coli) challenge
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Result:Reduced peritoneal bacterial counts.
Increased the levels of IL-1β, KC and MIP-2 in the peritoneal lavage fluid.
Recruited neutrophils to the peritoneum.
Chemical Information
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CAS No. 20978-32-9
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Molecular Weight 573.13
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Formula C10H13N5Na3O13P3
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O3
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Synonyms
Adenosine 5'-triphosphate trisodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (164)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Cyclic guanosine monophosphate-protein kinase G signaling attenuates aortic valve calcification through ULK1-mediated autophagy. [Abstract]2026 Mar 12;11(1):90. PMID: 41820291 -
Cell
Structural basis for the concurrence of template recycling and RNA capping in SARS-CoV-2. [Abstract]2025 Dec 11;188(25):7194-7205.e10. PMID: 41130208 -
Cell
Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity. [Abstract]2025 Jul 24;188(15):4025-4042.e20. PMID: 40592325 -
Cell
Cyclic-dinucleotide-induced filamentous assembly of phospholipases governs broad CBASS immunity. [Abstract]2025 Jul 10;188(14):3744-3756.e16. PMID: 40345202 -
Cell Metab
Hepatocyte-to-intestinal stem cell remote communication regulates blood glucose homeostasis. [Abstract]2026 Jul 7;38(7):1367-1384.e9. PMID: 42309059 -
Cell Metab
Adipokine IL-11/IL-11Ra constrains sphingolipid metabolism to limit the thermogenic capacity of beige adipocytes. [Abstract]2026 May 14:S1550-4131(26)00151-8. PMID: 42140185 -
Cell Res
Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses. [Abstract]2025 Feb;35(2):97-116. PMID: 39757301 -
Immunity
Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor. [Abstract]2025 Sep 9;58(9):2320-2335.e9. PMID: 40818452 -
Immunity
Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety. [Abstract]2024 Mar 12;57(3):495-512.e11. PMID: 38395698
ATP trisodium purchased from MedChemExpress. Usage Cited in: Immunity. 2024 Mar 12;57(3):495-512.e11. [Abstract]
Representative western blots and analyses of the following proteins in BV2 cells treated with vehicle (Con), LPS (200 ng/ml, 3 h), LPS + ATP (3 mM, 30 min), or LPS + ATP-siNKAα1.
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Cancer Res
Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells. [Abstract]2025 Jul 25. PMID: 40712058 -
Autophagy
H3K18la- driven neutrophil secretory autophagy promotes pulmonary endothelial dysfunction in sepsis-induced lung injury. [Abstract]2026 Jun 12:1-18. PMID: 42283498 -
Autophagy
2026 Jun 25:1-16. PMID: 42290138 -
Autophagy
Exercise hormone irisin alleviates rheumatoid arthritis by removing dysfunctional mitochondria. [Abstract]2026 May 25. PMID: 42186185 -
Autophagy
Integrated clinical and computational data-based repurposing of econazole as a novel autophagic activator in ULK1-related Parkinson disease. [Abstract]2026 May 17:1-21. PMID: 42112758 -
Autophagy
ESCRT III-mediated lysosomal repair improve renal tubular cell injury in cisplatin-induced AKI. [Abstract]2025 Sep;21(9):1927-1944. PMID: 40152606 -
Autophagy
Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice. [Abstract]2025 Aug 16. PMID: 40818063 -
Protein Cell
Drug target inference by mining transcriptional data using a novel graph convolutional network framework. [Abstract]2022 Apr;13(4):281-301. PMID: 34677780 -
ACS Nano
2023 Dec 12;17(23):23872-23888. PMID: 38084420 -
J Adv Res
PERK drives aflatoxin B1-induced chicken cellular senescence by promoting NLRP3-mediated PANoptosis. [Abstract]2026 May 20:S2090-1232(26)00426-1. PMID: 42155716 -
J Adv Res
Conjugated bile acids facilitate cholangiocyte senescence to promote cholestatic liver diseases via STING signaling. [Abstract]2026 Mar 12:S2090-1232(26)00239-0. PMID: 41831676 -
Redox Biol
TRPV4 drives macrophage pyroptosis via mitochondrial dysfunction and mtROS-dependent NLRP3 inflammasome activation in acute lung injury. [Abstract]2026 Jun 11:95:104255. PMID: 42314332 -
Mol Cell
Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer. [Abstract]2026 Jan 8;86(1):150-165.e9. PMID: 41435838 -
Mol Cell
2023 Jun 15;83(12):2137-2147.e4. PMID: 37244256 -
Mol Cell
Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS. [Abstract]2022 Jun 2;82(11):2032-2049.e7. PMID: 35460603 -
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Adv Sci (Weinh)
BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow-Transit Constipation. [Abstract]2026 Jun 12:e23688. PMID: 42284509 -
Adv Sci (Weinh)
Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice. [Abstract]2025 Nov 11:e08957. PMID: 41215712 -
Adv Sci (Weinh)
Acetylation of the Mitochondrial Chaperone GRP75 Governs ER-Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance. [Abstract]2025 Sep 26:e08991. PMID: 41001747 -
Adv Sci (Weinh)
2025 Aug;12(31):e01532. PMID: 40492417 -
Cell Rep Med
Metabolically engineered probiotic OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy. [Abstract]2026 Jun 16;7(6):102842. PMID: 42229426 -
Cell Death Differ
OR2T6 modulates autophagy through the PPP3CA-mediated pathways to suppress gastric cancer. [Abstract]2025 Nov 10. PMID: 41214150 -
Cell Death Differ
2022 Feb;29(2):439-450. PMID: 34511601
ATP trisodium purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2022 Feb;29(2):439-450. [Abstract]
Primary BMDM cells were isolated from WT and Trim21-/- C57BL/6 mice. Cells were primed with 1 μg/mL LPS for 2 h followed by 5 mM ATP or 20 μM Nig or 30 μM flagellin for 30 min. Cell viability are determined by the Cell Counting Kit-8.
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Carbohydr Polym
The effect of doxycycline-containing chitosan/carboxymethyl chitosan nanoparticles on NLRP3 inflammasome in periodontal disease. [Abstract]2020 Jun 1:237:116163. PMID: 32241426 -
Pharmacol Res
Plumbagin ameliorates multiple sclerosis by inducing DDX3X-mediated stress granule assembly in mice. [Abstract]2026 Jul:229:108257. PMID: 42167385 -
Cell Death Dis
Inhibition of p38 MAPK or immunoproteasome overcomes resistance of chronic lymphocytic leukemia cells to Bcl-2 antagonist venetoclax. [Abstract]2022 Oct 8;13(10):860. PMID: 36209148 -
Cell Death Dis
2021 Dec 14;12(12):1159. PMID: 34907173 -
Cell Death Dis
Silencing lncRNA Lfar1 alleviates the classical activation and pyoptosis of macrophage in hepatic fibrosis. [Abstract]2020 Feb 18;11(2):132. PMID: 32071306
ATP trisodium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Feb 18;11(2):132. [Abstract]
KCs were stimulated with 100 ng/mL LPS for 4 hours and subsequently treated them with 5 mM ATP for 2 hours to induce pyroptosis. The RNA level of lnc-Lfar1 was determined by qRT-PCR.
ATP trisodium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Feb 18;11(2):132. [Abstract]
KCs were transfected with lnc-Lfar1 siRNA for 24 h, followed by stimulation with 100 ng/ml LPS for 4 h and subsequently treated with 5 mM ATP or 100 ng/ml for 2 h to induce pyroptosis. a, b The protein level of NLRP3, Caspase1 and GSDMD was determined by western blot. GAPDH was used as an internal control.
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Cancer Lett
Sulforaphane suppresses bladder cancer metastasis via blocking actin nucleation-mediated pseudopodia formation. [Abstract]2024 Oct 1:601:217145. PMID: 39084455 -
Biosens Bioelectron
2021 Apr 15:178:113025. PMID: 33529860 -
Cell Commun Signal
JC124 confers multimodal neuroprotection in epilepsy by suppressing NLRP3 inflammasome activation: evidence from animal and human neuronal models. [Abstract]2025 Jul 8;23(1):327. PMID: 40629339 -
Crit Care
Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury. [Abstract]2021 Oct 12;25(1):356. PMID: 34641966
ATP trisodium purchased from MedChemExpress. Usage Cited in: Crit Care. 2021 Oct 12;25(1):356. [Abstract]
Stimulation of Raw264.7 macrophages with PBS/PBS-Exo/TNF-Exo for 24 h and treatment with PBS, 5 mM ATP or 20 mM nigericin for 2 h. Cleavage of GSDMD by western blot. GSDMD-FL: full-length GSDMD, GSDMD-N: N-terminal cleavage products of GSDMD.
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Phytomedicine
Isodeoxyelephantopin mitigates DSS-induced ulcerative colitis by suppressing IL-1β-driven inflammation via the TXNIP/NLRP3 axis. [Abstract]2026 Jan 16:153:157839. PMID: 41655542 -
Phytomedicine
Sclareol alleviates synovial inflammation in knee osteoarthritis by regulating sphingolipid metabolism along the gut-bone axis. [Abstract]2025 Dec:149:157563. PMID: 41273871 -
Phytomedicine
Ophiopogonin C protects against acute lung injury by fatal sepsis through pyroptosis macrophage. [Abstract]2025 Jul:142:156698. PMID: 40397999 -
Phytomedicine
Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARα/LACC1/NF-κB signaling pathway. [Abstract]2024 Jan:123:155193. PMID: 37976692 -
Phytomedicine
Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1/FXR signaling in bile duct ligation-induced liver fibrosis. [Abstract]2023 Sep:118:154971. PMID: 37494875 -
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Mater Today Bio
Nanotube topography inhibits NLRP3 inflammasome activation by reducing microtubule glutamylation. [Abstract]2025 May 10:32:101838. PMID: 40487178 -
Mater Today Bio
Nature-derived microneedles with metal-polyphenolic networks encapsulation for chronic soft tissue defects repair: Responding and remodeling the regenerative microenvironment. [Abstract]2025 Feb 1:31:101539. PMID: 40026624 -
ACS Sens
A Sensitive Green-Red FRET Sensor for Calpain-1 Utilizing Heterodimeric Fluorescent Proteins from Distinct Evolutionary Origins. [Abstract]2026 Mar 27;11(3):1891-1907. PMID: 41837894 -
J Hazard Mater
Protection against deoxynivalenol (DON)-induced intestinal injury by sulforaphane via modulation of lysosomal function. [Abstract]2026 Jan 1:501:140687. PMID: 41352012 -
Acta Pharmacol Sin
Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment. [Abstract]2025 Jul 17. PMID: 40676218 -
Acta Pharmacol Sin
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colonocytes and alleviates ulcerative colitis in mice by the small compound PEITC. [Abstract]2025 Apr 7. PMID: 40195510 -
Acta Pharmacol Sin
Sapidolide A alleviates acetaminophen-induced acute liver injury by inhibiting NLRP3 inflammasome activation in macrophages. [Abstract]2022 Aug;43(8):2016-2025. PMID: 35022542 -
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J Transl Med
Vascular restenosis following paclitaxel-coated balloon therapy is attributable to NLRP3 activation and LIN9 upregulation. [Abstract]2024 Sep 27;22(1):871. PMID: 39334121 -
Proc Natl Acad Sci U S A
Stepwise activation of SARM1 for cell death and axon degeneration revealed by a biosynthetic NMN mimic. [Abstract]2025 Feb 25;122(8):e2424906122. PMID: 39964720 -
Int J Biol Macromol
NIM5 series brain-penetrant NLRP3 inflammasome inhibitors suppress neuroinflammation in EAE and Alzheimer's models. [Abstract]2026 May:361:151905. PMID: 41962712 -
Int J Biol Macromol
2025 Dec 30;339(Pt 2):149976. PMID: 41478474 -
Int J Biol Macromol
2024 Apr 27;268(Pt 2):131779. PMID: 38679250 -
EMBO J
Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization. [Abstract]2025 Aug 18. PMID: 40826181 -
Mol Med
4-Octyl itaconate alleviates endothelial cell inflammation and barrier dysfunction in LPS-induced sepsis via modulating TLR4/MAPK/NF-κB signaling : 4-Octyl itaconate alleviates endothelial dysfunction. [Abstract]2025 Jun 16;31(1):240. PMID: 40524158 -
Antioxidants (Basel)
2023 Jun 19;12(6):1304. PMID: 37372033 -
Antioxidants (Basel)
Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway. [Abstract]2022 Nov 23;11(12):2315. PMID: 36552524 -
Free Radic Biol Med
Targeted delivery of nebivolol via lactoferrin-modified liposomes inhibits NEK7-mediated pyroptosis to ameliorate inflammatory bowel disease. [Abstract]2026 Aug 16:252:493-508. PMID: 42061481 -
Free Radic Biol Med
Paeoniflorin mitigates myocardial hypertrophy by regulating mitophagy and ferroptosis mediated by mitochondria-associated AMPK-Parkin-ACSL4 pathway. [Abstract]2025 Dec 22:245:98-114. PMID: 41443335 -
Stem Cell Res Ther
Enhance the therapeutic efficacy of human umbilical cord-derived mesenchymal stem cells in prevention of acute graft-versus-host disease through CRISPLD2 modulation. [Abstract]2025 May 1;16(1):222. PMID: 40312744 -
Am J Chin Med
Ophiopogonin D from Ophiopogon japonicas-induced USP25 Activity to Reduce Ferroptosis of Macrophage in Acute Lung Injury by the Inhibition of Bound Rac1 and Nox1 Complex. [Abstract]2025;53(2):501-522. PMID: 40099394 -
Cell Rep
Glutamine synthetase modulates YAP activation by stabilizing LATS under glutamine homeostasis. [Abstract]2025 Nov 25;44(12):116620. PMID: 41296569 -
Cell Rep
Ergosterol alleviates hepatic steatosis and insulin resistance via promoting fatty acid β-oxidation by activating mitochondrial ACSL1. [Abstract]2025 Jan 10;44(1):115203. PMID: 39799570 -
Cell Rep
Translocational attenuation mediated by the PERK-SRP14 axis is a protective mechanism of unfolded protein response. [Abstract]2024 Jun 27;43(7):114402. PMID: 38943644 -
Cell Rep
NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells. [Abstract]2021 Aug 10;36(6):109516. PMID: 34380043 -
Cell Prolif
2023 Sep;56(9):e13442. PMID: 37086012 -
Br J Pharmacol
Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule-based mitochondrial transport disorder to morphine tolerance. [Abstract]2025 May 13. PMID: 40361281 -
J Med Chem
Platinum-Paeonol Complexes as ERK Inhibitors To Restrain Melanoma and Relieve Cancer Pain. [Abstract]2026 Apr 9;69(7):7663-7676. PMID: 41873204 -
Anal Chem
Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]2025 May 13;97(18):9827-9835. PMID: 40302637 -
Cancer Cell Int
Gastric cancer cell-originated small extracellular vesicle induces metabolic reprogramming of BM-MSCs through ERK-PPARγ-CPT1A signaling to potentiate lymphatic metastasis. [Abstract]2023 May 9;23(1):87. PMID: 37158903 -
J Ethnopharmacol
Combining LC/IM-QTOF-MS with serum pharmacochemistry to identify active compounds and functional mechanisms of Fritillaria ussuriensis in asthma. [Abstract]2026 May 10:362:121370. PMID: 41687937 -
J Ethnopharmacol
Didymin alleviates neuropathic pain by targeting RKIP-mediated NF-κB/NLRP3 crosstalk to inhibit pyroptosis and neuroinflammation. [Abstract]2026 Mar 25:359:121046. PMID: 41453551 -
J Ethnopharmacol
Ginsenoside Rg1 improves chronic neuropathic pain by inhibiting NLRP3 inflammasome activation and cell pyroptosis in microglia. [Abstract]2025 Jul 30;353(Pt A):120346. PMID: 40750033 -
J Ethnopharmacol
Si-Wu-Tang attenuates hepatocyte PANoptosis and M1 polarization of macrophages in non-alcoholic fatty liver disease by influencing the intercellular transfer of mtDNA. [Abstract]2024 Jun 28:328:118057. PMID: 38518965 -
J Ethnopharmacol
Buyang Huanwu Decoction suppresses cardiac inflammation and fibrosis in mice after myocardial infarction through inhibition of the TLR4 signalling pathway. [Abstract]2024 Feb 10:320:117388. PMID: 37949329 -
Eur J Med Chem
Synthesis and pharmacological evaluation of brominated derivatives of natural product celastrol for treatment of hepatic fibrosis. [Abstract]2026 May 5:309:118765. PMID: 41844113 -
J Agric Food Chem
Calenduloside E Ameliorates Inflammatory Responses in Adipose Tissue via Sirtuin 2-NLRP3 Inflammasome Axis. [Abstract]2024 Sep 25;72(38):20959-20973. PMID: 39282743 -
Biochem Pharmacol
Targeting the DYNLL2-PAK1 axis inhibits caspase-11-dependent pyroptosis to alleviate sepsis. [Abstract]2026 Feb:244:117614. PMID: 41360226 -
Biochem Pharmacol
Tamibarotene directly targets the NACHT domain of NLRP3 to alleviate acute myocardial infarction. [Abstract]2025 Apr:234:116801. PMID: 39952330 -
Biochem Pharmacol
BACH1 impairs hepatocyte regeneration after hepatectomy with repeated ischemia/reperfusion by reprogramming energy metabolism and exacerbating oxidative stress. [Abstract]2024 Aug:226:116377. PMID: 38906228 -
Life Sci
GYY4137 alleviates sepsis-induced acute lung injury in mice by inhibiting the PDGFRβ/Akt/NF-κB/NLRP3 pathway. [Abstract]2021 Apr 15:271:119192. PMID: 33577850 -
Food Funct
Ketogenic diet attenuates microglia-mediated neuroinflammation by inhibiting NLRP3 inflammasome activation via HDAC3 inhibition to activate mitophagy in experimental autoimmune encephalomyelitis. [Abstract]2025 Jun 16;16(12):4731-4753. PMID: 40421817 -
Transl Res
Non-canonical NF-κB contributes to endothelial pyroptosis and atherogenesis dependent on IRF-1. [Abstract]2023 May:255:1-13. PMID: 36384204
ATP trisodium purchased from MedChemExpress. Usage Cited in: Transl Res. 2023 May:255:1-13. [Abstract]
LPS/ATP treatment significantly promotes expression of NLRP3 and production of N-GSDMD in HAEC. HAEC are pretreated with LPS (500ng/ml) for 5 h and then stimulated with ATP (5 mM) for 1 h.
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Anal Chim Acta
2021 Dec 15:1188:339180. PMID: 34794559 -
Nutrients
Dietary Flavone Baicalein Combinate with Genipin Attenuates Inflammation Stimulated by Lipopolysaccharide in RAW264.7 Cells or Pseudomonas aeruginosa in Mice via Regulating the Expression and Phosphorylation of AKT. [Abstract]2021 Dec 14;13(12):4462. PMID: 34960014 -
Eur J Pharmacol
Blockade of KCa3.1 ameliorates rheumatoid arthritis by suppressing macrophage M1 polarization via the NLRP3 inflammasome signaling pathway. [Abstract]2026 Mar 28:1019:178738. PMID: 41794275 -
Respir Res
Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3. [Abstract]2024 Jul 30;25(1):291. PMID: 39080660 -
Eur J Pharmacol
Bazedoxifene attenuates intestinal injury in sepsis by suppressing the NF-κB/NLRP3 signaling pathways. [Abstract]2023 May 15:947:175681. PMID: 36965746 -
Eur J Pharmacol
2022 Feb 5:916:174729. PMID: 34973190 -
Int Immunopharmacol
Paeonol mitigates age-related osteoporosis via mitophagy-mediated NLRP3 inflammasome inhibition. [Abstract]2026 Aug 1:182:116787. PMID: 42096961 -
Int J Mol Sci
Mitochondrial Calcium Overload Drives mtDNA-cGAS-STING Activation via VDAC1 and MCU Upregulation in Periodontitis. [Abstract]2026 May 12;27(10):4317. PMID: 42196298 -
Int Immunopharmacol
Coptisine alleviates intestinal barrier dysfunction and inflammation in TNBS-induced colitis rats and LPS-stimulated human intestinal Caco-2 cells. [Abstract]2025 Dec 10:167:115697. PMID: 41130089 -
Int Immunopharmacol
Crocin facilitates peripheral nerve regeneration through modulation of the STAT3/Bcl-2/Beclin-1 signaling axis-mediated autophagic pathway. [Abstract]2025 Sep 5:165:115437. PMID: 40913861 -
Int Immunopharmacol
Urolithin A alleviates NLRP3 inflammasome activation and pyroptosis by promoting microglial mitophagy following spinal cord injury. [Abstract]2025 Feb 20:148:114057. PMID: 39827665 -
Int Immunopharmacol
CHS-Ⅳa activates the IGF1R/PI3K signal pathway with inhibited pyroptosis of endometrial stromal cells and progress of endometriosis. [Abstract]2024 Nov 2;143(Pt 3):113527. PMID: 39488924 -
Int J Mol Sci
Betulonic Acid Inhibits Type-2 Porcine Reproductive and Respiratory Syndrome Virus Replication by Downregulating Cellular ATP Production. [Abstract]2024 Sep 26;25(19):10366. PMID: 39408695 -
Int Immunopharmacol
Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation. [Abstract]2023 Mar:116:109747. PMID: 36706592 -
Neurochem Int
Proteostasis and autophagy disruption by the aging-related VGVAPG hexapeptide - preliminary insights into a potential novel elastin-induced neurodegeneration pathway in an in vitro human cellular neuron model. [Abstract]2025 Jul:187:105992. PMID: 40348194 -
Inflammation
Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling. [Abstract]2025 Dec 20;49(1):11. PMID: 41420798 -
Biochim Biophys Acta Mol Basis Dis
Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages. [Abstract]2024 Jan;1870(1):166895. PMID: 37748566 -
Sci Rep
Metrnl ameliorates ulcerative colitis by inhibiting NLRP3 inflammasome activation via ASC. [Abstract]2026 Jun 11. PMID: 42277107 -
Exp Neurol
Semaglutide attenuates Alzheimer's disease model progression by targeting microglial NLRP3 inflammasome-mediated neuroinflammation and ferroptosis. [Abstract]2026 Feb:396:115537. PMID: 41173224 -
J Cell Mol Med
Resveratrol Upregulates miR-124-3p Expression to Target DAPK1, Regulating the NLRP3/Caspase-1/GSDMD Pathway to Inhibit Pyroptosis and Alleviate Spinal Cord Injury. [Abstract]2025 Jan;29(2):e70338. PMID: 39833100 -
Appl Microbiol Biotechnol
Preparation and characterization of monoclonal antibodies against porcine gasdermin D protein. [Abstract]2024 Jan 25;108(1):173. PMID: 38267794 -
J Inflamm Res
Cell Death-Related Genesets Activity Improved Clinical Concordance and Intrinsically Associated with Alterations in Ulcerative Colitis: Mucosal Healing at Molecular Depth. [Abstract]2025 Jul 19:18:9587-9608. PMID: 40708727 -
Structure
2025 May 1;33(5):903-915.e5. PMID: 40101709 -
Biochim Biophys Acta Mol Cell Res
2024 Mar 22;1871(4):119712. PMID: 38521466 -
Biochim Biophys Acta Mol Cell Res
Interplay between SUMO1-related SUMOylation and phosphorylation of p65 promotes hepatocellular carcinoma progression. [Abstract]2024 Jan;1871(1):119595. PMID: 37730133 -
FEBS J
2026 Mar 10. PMID: 41804674 -
Immunotargets Ther
NLRP3 Inflammasome Upregulates PD-L1 in Ovarian Cancer and Contributes to an Immunosuppressive Microenvironment. [Abstract]2024 Dec 14:13:775-788. PMID: 39703562 -
J Virol
Pseudorabies Virus Infection Activates the TLR-NF-κB Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice. [Abstract]2023 Mar 30;97(3):e0000323. PMID: 36877049 -
Front Neurosci
Extracellular Adenosine Triphosphate Binding to P2Y1 Receptors Prevents Glutamate-Induced Excitotoxicity: Involvement of Erk1/2 Signaling Pathway to Suppress Autophagy. [Abstract]2022 Jun 7;16:901688. PMID: 35747207 -
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Reprod Biomed Online
Blockage of the NLRP3 inflammasome by MCC950 inhibits migration and invasion in adenomyosis. [Abstract]2024 Oct;49(4):104319. PMID: 39121559 -
Neuromolecular Med
SS-31 Improves Cognitive Function in Sepsis-Associated Encephalopathy by Inhibiting the Drp1-NLRP3 Inflammasome Activation. [Abstract]2023 Jun;25(2):230-241. PMID: 36333543 -
Mol Immunol
Hyperactivation of succinate dehydrogenase promotes pyroptosis of macrophage via ROS-induced GSDMD oligomerization in acute liver failure. [Abstract]2024 May:169:86-98. PMID: 38552285 -
J Dent Sci
Micro-/nano-structured zirconia surface promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by reducing pyroptosis under inflammatory conditions. [Abstract]2025 Jul;20(3):1422-1435. PMID: 40654428 -
Clin Oral Investig
The protective role of curcumin in human dental pulp stem cells stimulated by lipopolysaccharide via inhibiting NF-κB p65 phosphorylation to suppress NLRP3 inflammasome activation. [Abstract]2023 Jun;27(6):2875-2885. PMID: 36735089 -
Immun Inflamm Dis
Exosomal miR-1246 in Syphilis Serofast State: Diagnostic Value and NLRP3 Inflammasome Suppression. [Abstract]2026 Apr;14(4):e70434. PMID: 41958142 -
Int J Biochem Cell Biol
Paxillin mediates lung epithelial injury by activating NLRP3 inflammasomes in an acute respiratory distress syndrome mouse model. [Abstract]2026 Jan:190:106880. PMID: 41265698 -
Bioorg Med Chem
Synthesis and biological evaluation of all possible inosine-mixed cyclic dinucleotides that activate different hSTING variants. [Abstract]2021 Jan 1:29:115899. PMID: 33285409 -
Hypertens Pregnancy
KAT2A promotes NLRP3-mediated trophoblast pyroptosis in preeclampsia by the succinylation. [Abstract]2026 Dec 31;45(1):2609374. PMID: 41473982 -
J Fluoresc
Label-Free Fluorescent Detection of T4 PNK Using a DNA Mimic Green Fluorescent Protein-Based Turn-On Biosensor. [Abstract]2026 Jun;36(6):3899-3908. PMID: 42209914 -
Mol Biol Rep
Fucoxanthin regulates macrophage pyroptosis through the PI3K/AKT/mTOR signalling pathway. [Abstract]2026 Jan 3;53(1):250. PMID: 41483374 -
Placenta
Endoplasmic reticulum stress induces trophoblast pyroptosis via regulating CYLD during labor initiation. [Abstract]2025 May 22:167:204-215. PMID: 40418867 -
Oral Dis
Repurposing disulfiram to induce OSCC cell death by cristae dysfunction promoted autophagy. [Abstract]2021 Jul;27(5):1148-1160. PMID: 32989819 -
Vet Microbiol
FCV activates NLRP3 inflammasome through ion-dependent pathway to promote IL-1β secretion. [Abstract]2025 Aug:307:110628. PMID: 40602240 -
Vet Sci
Porcine Epidemic Diarrhea Virus Infection of Porcine Intestinal Epithelial Cells Causes Mitochondrial DNA Release and the Activation of the NLRP3 Inflammasome to Mediate Interleukin-1β Secretion. [Abstract]2024 Dec 12;11(12):643. PMID: 39728983 -
Biochemistry
Full-Length NAD+-I Riboswitches Bind a Single Cofactor but Cannot Discriminate against Adenosine Triphosphate. [Abstract]2023 Dec 5;62(23):3396-3410. PMID: 37947391 -
Biochem Biophys Res Commun
Feedback activation of CD73-Adenosine axis attenuates the antitumor immunity of STING pathway. [Abstract]2024 May 14:708:149814. PMID: 38531218 -
Arch Oral Biol
Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. [Abstract]2019 Nov:107:104514. PMID: 31394382 -
Cytotechnology
E2F2 induces microglial activation and augments depressive-like behavior in mice by repressing PTPN6 transcription. [Abstract]2025 Apr;77(2):66. PMID: 39991704 -
Cardiovasc Pathol
Trimethylamine N-oxide drives bioprosthetic heart valve calcification via macrophage pyroptosis in juvenile rats. [Abstract]2025 Nov-Dec:79:107750. PMID: 40619044 -
Int J Dev Neurosci
Gentiopicroside alleviated epileptogenesis in immature rats through inactivation of NLRP3 inflammasome by inhibiting P2X7R expression. [Abstract]2023 Feb;83(1):53-66. PMID: 36342791 -
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Biomed Pharmacother
Docking and database screening identify manidipine as a potential modulator of matrix metalloproteinase-7 in chronic kidney disease. [Abstract]2025 Dec:193:118748. PMID: 41232355 -
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Biomed Pharmacother
Cilostazol attenuates vascular inflammation via the regulation of TICAM1/IRF3 signaling pathway. [Abstract]2025 Aug:189:118275. PMID: 40532577 -
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Heliyon
Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight. [Abstract]2024 Sep 19;10(19):e38050. PMID: 39386862 -
Biomed Pharmacother
Bongkrekic acid alleviates airway inflammation via breaking the mPTP/mtDAMPs/RAGE feedback loop in a steroid-insensitive asthma model. [Abstract]2024 Aug:177:117111. PMID: 39013220 -
Biomed Pharmacother
Gentiopicroside improves NASH and liver fibrosis by suppressing TLR4 and NLRP3 signaling pathways. [Abstract]2024 Aug:177:116952. PMID: 38917754 -
Biomed Pharmacother
Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. [Abstract]2024 Aug:177:117006. PMID: 38908197 -
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Aging (Albany NY)
2021 Sep 28;13(18):22588-22610. PMID: 34584017 -
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Aging (Albany NY)
Inhibition of complement C5a receptor protects lung cells and tissues against lipopolysaccharide-induced injury via blocking pyroptosis. [Abstract]2021 Mar 10;13(6):8588-8598. PMID: 33714207
Purity & Documentation
References
[1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8. [Content Brief]
[2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [Content Brief]
[3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [Content Brief]
[4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ATP trisodium Related Classifications
HY-B2176J Related Classifications
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