EZH2-IN-18
EZH2-IN-18 (compound 9e) is a potent inhibitor of enhancer of zeste homologue 2 (EZH2WT) , with the IC50 of 1.01 nM. EZH2-IN-18 shows inhibition in proliferation and induction in apoptosis in tumor cells.
For research use only. We do not sell to patients.
- CAS No.: 2826234-37-9
- Formula: C24H20BrN3O3
- Molecular Weight:478.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
11.04 μM
Compound: 9e
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Antiproliferative activity against human A549 cells by MTT assay
Antiproliferative activity against human A549 cells by MTT assay
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[PMID: 38580135] |
| HeLa | IC50 |
25.33 μM
Compound: 9e
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Antiproliferative activity against human HeLa cells by MTT assay
Antiproliferative activity against human HeLa cells by MTT assay
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[PMID: 38580135] |
Chemical Information
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CAS No. 2826234-37-9
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Molecular Weight 478.34
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Formula C24H20BrN3O3
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SMILES
O=C1C(CNC(C2=CC(C3=CC=C(Br)C=C3)=CC(N4)=C2C=CC4=O)=O)=C(C)C=C(C)N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EZH2-IN-18 Related Classifications
HY-161419 Related Classifications
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