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LTN1 - listerin E3 ubiquitin protein ligase 1 Gene

Also Known as RNF160; ZNF294; C21orf10; C21orf98

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26046

About LTN1

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:28,928,144-28,992,877 (from NCBI)

This gene has 7 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in thyroid (RPKM 7.5), placenta (RPKM 7.3) and 25 other tissues.

Summary

Like most RING finger proteins, LTN1 functions as an E3 ubiquitin Ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]

LTN1 Products (2)

mRNA	Protein	Name
NM_001320766.2	NP_001307695.2	E3 ubiquitin-protein ligase listerin isoform 2
NM_015565.3	NP_056380.3	E3 ubiquitin-protein ligase listerin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	25578875	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	25578875	GOA
involved in ribosome-associated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	25578875	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RQC complex	IDA IDA: Inferred from direct assay	25578875	GOA
located in cytosol	IDA IDA: Inferred from direct assay	25578875	GOA
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	25578875	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LTN1 Protein Structure

FANCL_C

0
300
600
900
1200
1500
1766 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase listerin	RING-type E3 ubiquitin transferase listerin

LTN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LTN1	O94822	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	21903422
Intra	LTN1	O94822	TIRAP	Homo sapiens	P58753	Anti Tag CoIP	21903422
Intra	LTN1	O94822	IRF7	Homo sapiens	Q92985	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07885	LTN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22226	Ltn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LTN1	MGD	MGI:1926163
Macaca mulatta	LTN1	VGNC	VGNC:74275
Canis familiaris	LTN1	VGNC	VGNC:42862
Bos taurus	LTN1	VGNC	VGNC:31078
Rattus norvegicus	LTN1	RGD	RGD:1311238
Felis catus	LTN1	VGNC	VGNC:63327
Others	LTN1	NCBI