Cat. No.: HY-N6009

8-Deoxygartanin

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8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE). 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM.

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Pureté: 99.47%
CAS No.: 33390-41-9
Formule: C₂₃H₂₄O₅
Masse moléculaire:380.43

Stockage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

8-Deoxygartanin Chemical Structure

CAS No.: 33390-41-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE)^[1]. 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum^[2]. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM^[3].

IC₅₀ & Target

Plasmodium

p65

11.3 μM (IC₅₀)

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Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	IC₅₀	4.9 μg/mL Compound: 5	Cytotoxicity against human CEM-SS cells Cytotoxicity against human CEM-SS cells	[PMID: 11087602]
HT-29	ED₅₀	>10 μM Compound: 9	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 19839614]

Chemical Information

CAS No. 33390-41-9
Appearance Solid
Masse moléculaire 380.43
Formule C₂₃H₂₄O₅
Color Light yellow to yellow
SMILES

C/C(C)=C\CC1=C(O)C(C/C=C(C)/C)=C(O)C(C(C2=CC=C3)=O)=C1OC2=C3O
Structure Classification
- Phenols
- Polyphenols
- Phenols
- Xanthones
Initial Source
- Plants
- other families
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (262.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6286 mL

13.1430 mL

26.2860 mL

5 mM

0.5257 mL

2.6286 mL

5.2572 mL

10 mM

0.2629 mL

1.3143 mL

2.6286 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Khaw KY, et al. Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies. Phytomedicine. 2014 Sep 25;21(11):1303-9. [Content Brief]

[2]. Ngouamegne ET, et al. Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides. Chem Pharm Bull (Tokyo). 2008 Mar;56(3):374-7. [Content Brief]

[3]. Han AR, et al. Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen). J Nat Prod. 2009 Nov;72(11):2028-31. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6286 mL	13.1430 mL	26.2860 mL	65.7151 mL
	5 mM	0.5257 mL	2.6286 mL	5.2572 mL	13.1430 mL
	10 mM	0.2629 mL	1.3143 mL	2.6286 mL	6.5715 mL
	15 mM	0.1752 mL	0.8762 mL	1.7524 mL	4.3810 mL
	20 mM	0.1314 mL	0.6572 mL	1.3143 mL	3.2858 mL
	25 mM	0.1051 mL	0.5257 mL	1.0514 mL	2.6286 mL
	30 mM	0.0876 mL	0.4381 mL	0.8762 mL	2.1905 mL
	40 mM	0.0657 mL	0.3286 mL	0.6572 mL	1.6429 mL
	50 mM	0.0526 mL	0.2629 mL	0.5257 mL	1.3143 mL
	60 mM	0.0438 mL	0.2191 mL	0.4381 mL	1.0953 mL
	80 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.8214 mL
	100 mM	0.0263 mL	0.1314 mL	0.2629 mL	0.6572 mL

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8-Deoxygartanin

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Voir tous les produits spécifiques à Isoform Parasite

Voir tous les produits spécifiques à Isoform NF-κB

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

8-Deoxygartanin Related Classifications

HY-N6009 Related Classifications