Cat. No.: HY-13418

Dorsomorphin dihydrochloride

(Synonyms: Compound C dihydrochloride; BML-275 dihydrochloride)

763 Cited Publications

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Based on 763 publication(s) in Google Scholar

Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a K_i of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).

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Pureté: 99.7%
CAS No.: 1219168-18-9
Formule: C₂₄H₂₇Cl₂N₅O
Masse moléculaire:472.41

Stockage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

Dorsomorphin dihydrochloride Chemical Structure

CAS No.: 1219168-18-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (763)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
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Activité biologique

Description

IC₅₀ & Target^[1]^[2]

AMPK

109 nM (Ki)

ACVR1

BMPR1A

ALK6

Autophagy

Voir tous les produits spécifiques à Isoform AMPK :

Voir tous les produits spécifiques à Isoform TGF-β Receptor :

In Vitro

Dorsomorphin (compound C; 0-10 μM; 18 h) dihydrochloride suppresses 2DG-induced GRP78 promoter activity in human fibrosarcoma HT1080 cells in a dose-dependent manner but has little effect on Tunicamycin (HY-A0098)-induced GRP78 promoter activity. Dorsomorphin dihydrochloride also suppresses GRP78 promoter activity induced by glucose withdrawal. Dorsomorphin dihydrochloride has no effect on 2DG-induced PERK activation and reduces the both basal and 2DG-induced AMPK phosphorylation levels in HT1080 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

Human fibrosarcoma HT1080 cells.
Concentration:

0-10 μM.
Incubation Time:

18 hours
Result:

Suppressed 2DG-induced GRP78 promoter activity in a dose-dependent manner and also suppressed GRP78 promoter activity induced by glucose withdrawal.

In Vivo

Dorsomorphin (compound C; 10 mg/kg, intravenously once) dihydrochloride treatment leads to a 60% increase in total serum iron concentrations, reduces basal levels of hepcidin expression and increases serum iron concentrations in adult mice^[3].
Dorsomorphin (0.2 mg/kg, i.v., 30 min before LPS injection) dihydrochloride reduces ICAM-1 and VCAM-1 expression in LPS-injected rat aorta^[4].
Dorsomorphin (25 mg/kg; i.p. injection, in male BALB/c mice) dihydrochloride treatment before lipopolysaccharide (LPS) injection significantly reduces lethality in contrast to animals treated with LPS challenge only^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wild-type (WT) C57BL/6 adult mice that are fed a standard iron-replete diet express high levels of hepcidin^[3].
Dosage:

10 mg/kg.
Administration:

Intravenously once.
Result:

Led to a 60% increase in total serum iron concentrations.
Effective in reducing basal levels of hepcidin expression and increasing serum iron concentrations in adult mice.

Animal Model:

Male Sprague-Dawley rats, 8 weeks of age (body weight 230-250 g)^[4].
Dosage:

0.2 mg/kg.
Administration:

I.V., 30 min before LPS injection.
Result:

Reduced ICAM-1 and VCAM-1 expression in LPS-injected rat aorta.

Animal Model:

Male BALB/c mice at 6-7 weeks of age weighing 20-22 g^[5]
Dosage:

25 mg/kg
Administration:

Injection i.p.; 60 min before LPS challenge
Result:

Treatment of mice with 25 mg/kg before LPS injection significantly reduced lethality in contrast to animals treated with LPS challenge only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1219168-18-9
Appearance Solid
Masse moléculaire 472.41
Formule C₂₄H₂₇Cl₂N₅O
Color Light yellow to yellow
SMILES

[H]Cl.[H]Cl.C12=C(C3=CC=NC=C3)C=NN1C=C(C4=CC=C(OCCN5CCCCC5)C=C4)C=N2
Synonyms

Compound C dihydrochloride; BML-275 dihydrochloride
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

Publications (763)

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Signal Transduct Target Ther

Myeloid but not hepatocytic CD38 is a key driver for hepatic ischemia/reperfusion injury. [Abstract]

2025 May 9;10(1):150. PMID: 40341132
Signal Transduct Target Ther

FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury. [Abstract]

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Nat Nanotechnol

Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer. [Abstract]

2021 Jul;16(7):830-839. PMID: 33958764
Mol Cancer

Inhibition of 6-phosphogluconate dehydrogenase suppresses esophageal squamous cell carcinoma growth and enhances the anti-tumor effects of metformin via the AMPK/mTOR pathway. [Abstract]

2025 Mar 26;24(1):97. PMID: 40140842
Cell Metab

The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity. [Abstract]

2021 Mar 2;33(3):565-580.e7. PMID: 33657393

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Mar 2;33(3):565-580.e7. [Abstract]

Immunoblots (proteins indicated) in C3H10T1/2-derived adipocytes incubated with or without AMPK inhibitor Compound C (CC) (10 μM) for 2 h and followed by HPF treatment for 48 h.
Adv Mater

A Hybrid Nanoadjuvant Simultaneously Depresses PD-L1/TGF-β1 and Activates cGAS-STING Pathway to Overcome Radio-Immunotherapy Resistance. [Abstract]

2024 Apr;36(15):e2304328. PMID: 38229577
Nat Biomed Eng

Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples. [Abstract]

2024 Sep;8(9):1109-1123. PMID: 39209948
Mil Med Res

Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways. [Abstract]

2023 Nov 25;10(1):56. PMID: 38001521
Mil Med Res

Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules. [Abstract]

2020 Sep 6;7(1):42. PMID: 32892745
Nat Metab

Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis. [Abstract]

2022 Sep;4(9):1185-1201. PMID: 36050503
Nat Metab

The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress. [Abstract]

2021 Oct;3(10):1357-1371. PMID: 34663976
Cell Stem Cell

Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages. [Abstract]

2025 Dec 4;32(12):1849-1868.e15. PMID: 41205597
Cell Stem Cell

Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming. [Abstract]

2023 Apr 6;30(4):450-459.e9. PMID: 36944335
Nat Cell Biol

TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy. [Abstract]

2026 Apr;28(4):812-827. PMID: 41803502
Cancer Res

MTHFD2 Enhances cMYC O-GlcNAcylation to Promote Sunitinib Resistance in Renal Cell Carcinoma. [Abstract]

2025 Mar 14;85(6):1113-1129. PMID: 39804969
Mol Cell

PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia. [Abstract]

2020 Jan 2;77(1):95-107.e5. PMID: 31628042
Cancer Res

Fructose-induced mTORC1 Activation Promotes Pancreatic Cancer Progression through Inhibition of Autophagy. [Abstract]

2023 Dec 15;83(24):4063-4079. PMID: 37738413
Mol Cell

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation. [Abstract]

2017 Oct 19;68(2):336-349.e6. PMID: 29053957
ACS Nano

Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction. [Abstract]

2024 Jul 2;18(26):16790-16807. PMID: 38869479

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Jul 2;18(26):16790-16807. [Abstract]

Dorsomorphin (Compound C) (5 μM; 6 h) inhibits NP (24 h)-induced p-AMPK, p-ULK1, ATG5, and LC3-II upregulation and SQSTM1 and GPX4 downregulation in TC-1 cells.

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Jul 2;18(26):16790-16807. [Abstract]

Dorsomorphin (Compound C) (5 μM; 6 h) can alleviate NPs-induced cell death in TC-1 cells.
Nat Commun

Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting. [Abstract]

2026 May 6. PMID: 42091861
Nat Commun

Rapid metabolic reprogramming mediated by the AMP-activated protein kinase during the lytic cycle of Toxoplasma gondii. [Abstract]

2023 Jan 26;14(1):422. PMID: 36702847
Cell Death Differ

NDUFS3 promotes proliferation via glucose metabolism reprogramming inducing AMPK phosphorylating PRPS1 to increase the purine nucleotide synthesis in melanoma. [Abstract]

2025 May 22. PMID: 40404919
Cell Death Differ

MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy. [Abstract]

2024 May 23. PMID: 38783090
Bone Res

Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction. [Abstract]

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Acta Pharm Sin B

Evidence that metformin promotes fibrosis resolution via activating alveolar epithelial stem cells and FGFR2b signaling. [Abstract]

2025 Sep;15(9):4711-4729. PMID: 41049730
Acta Pharm Sin B

Berberine improves central memory formation of CD8+ T cells: Implications for design of natural product-based vaccines. [Abstract]

2023 May;13(5):2259-2268. PMID: 37250162
Acta Pharm Sin B

Anthelmintics nitazoxanide protects against experimental hyperlipidemia and hepatic steatosis in hamsters and mice. [Abstract]

2022 Mar;12(3):1322-1338. PMID: 35530137
Autophagy

Buddleoside alleviates nonalcoholic steatohepatitis by targeting the AMPK-TFEB signaling pathway. [Abstract]

2025 Jun;21(6):1316-1334. PMID: 39936600
Autophagy

Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism. [Abstract]

2021 Dec;17(12):4141-4158. PMID: 33749503
Autophagy

m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells. [Abstract]

2021 Feb;17(2):457-475. PMID: 31983283
Adv Sci (Weinh)

Trigonelline Improves Metabolism and Cardiac Function of HFpEF Mice Via Gut Microbiome Alterations-Mediated AMPK Activation. [Abstract]

2025 Nov 5:e13956. PMID: 41194405
Adv Sci (Weinh)

BLOC1S1 Attenuates B. Melitensis 16M LPS-Triggered Autophagy by Spatial Confinement of TDP-43. [Abstract]

2025 Sep 11:e05635. PMID: 40936170
Adv Sci (Weinh)

Single-Cell RNA Sequencing Identifies MMP11+ Cancer-Associated Fibroblasts as Drivers of Angiogenesis and Bladder Cancer Progression. [Abstract]

2025 Jun 24:e02774. PMID: 40552583
Adv Sci (Weinh)

Adipose Tissue-Resident Sphingomonas Paucimobilis Suppresses Adaptive Thermogenesis by Reducing 15-HETE Production and Inhibiting AMPK Pathway. [Abstract]

2024 Dec;11(47):e2310236. PMID: 39476363
Theranostics

Therapeutic inhibition of miR-802 protects against obesity through AMPK-mediated regulation of hepatic lipid metabolism. [Abstract]

2021 Jan 1;11(3):1079-1099. PMID: 33391522
Theranostics

TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress. [Abstract]

2020 Jul 23;10(20):9280-9302. PMID: 32802192
Theranostics

Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma. [Abstract]

2020 Feb 10;10(8):3488-3502. PMID: 32206103
Chem Eng J

2025 Sep 15.
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1 January 2023, 138737.
J Adv Res

Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy. [Abstract]

2024 Dec 2:S2090-1232(24)00555-1. PMID: 39631519
J Adv Res

Aberrant activation of p53-TRIB3 axis contributes to diabetic myocardial insulin resistance and sulforaphane protection. [Abstract]

2024 Jul 26:S2090-1232(24)00307-2. PMID: 39069209
J Adv Res

Triad3A-Mediated K48-Linked ubiquitination and degradation of TLR9 impairs mitochondrial bioenergetics and exacerbates diabetic cardiomyopathy. [Abstract]

2024 Jul:61:65-81. PMID: 37625569
Biomaterials

Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration. [Abstract]

2021 Jul:274:120850. PMID: 33984637
J Exp Clin Cancer Res

Liensinine reshapes the immune microenvironment and enhances immunotherapy by reprogramming metabolism through the AMPK-HIF-1α axis in hepatocellular carcinoma. [Abstract]

2025 Jul 15;44(1):208. PMID: 40665352
J Exp Clin Cancer Res

Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma. [Abstract]

2022 Mar 30;41(1):116. PMID: 35354475
J Exp Clin Cancer Res

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer. [Abstract]

2021 Jun 23;40(1):206. PMID: 34162423
J Nanobiotechnology

Nanozymes subvert pharmacological conventions: insights from counteracting the placental side effects of TiO₂ nanozymes. [Abstract]

2026 Feb 7;24(1):227. PMID: 41654860
J Nanobiotechnology

Dual-responsive nanoparticles targeting ACE-II senescence for therapeutic mitigation of acute lung injury. [Abstract]

2025 May 8;23(1):339. PMID: 40340852
J Nanobiotechnology

Gouqi-derived nanovesicles (GqDNVs) inhibited dexamethasone-induced muscle atrophy associating with AMPK/SIRT1/PGC1α signaling pathway. [Abstract]

2024 May 22;22(1):276. PMID: 38778385
Cell Discov

ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression. [Abstract]

2026 Feb 24;12(1):13. PMID: 41730846
Sci Adv

Bacteriocin-transport-inspired oral peptide-probiotic delivery ameliorates IBD complications via autophagy and gut homeostasis. [Abstract]

2026 Jan 2;12(1):eadz9069. PMID: 41481708
Sci Adv

Atf3-mediated metabolic reprogramming in hepatic macrophage orchestrates metabolic dysfunction-associated steatohepatitis. [Abstract]

2024 Jul 26;10(30):eado3141. PMID: 39047111
Carbohydr Polym

Chitosan oligosaccharide regulates AMPK and STAT1 pathways synergistically to mediate PD-L1 expression for cancer chemoimmunotherapy. [Abstract]

2022 Feb 1:277:118869. PMID: 34893274
Mol Ther

TAT-PBX1 fusion protein alleviates LPS-induced acute lung injury via AMPK-TFAM signaling activation. [Abstract]

2025 Sep 8:S1525-0016(25)00738-5. PMID: 40926413
Redox Biol

α-Ketoglutarate prevents hyperlipidemia-induced fatty liver mitochondrial dysfunction and oxidative stress by activating the AMPK-pgc-1α/Nrf2 pathway. [Abstract]

2024 Aug:74:103230. PMID: 38875959
Redox Biol

Cyclic helix B peptide alleviates proinflammatory cell death and improves functional recovery after traumatic spinal cord injury. [Abstract]

2023 Aug:64:102767. PMID: 37290302
Metabolism

LSD1 mediates microbial metabolite butyrate-induced thermogenesis in brown and white adipose tissue. [Abstract]

2020 Jan;102:154011. PMID: 31734274
Redox Biol

Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration. [Abstract]

2018 Oct;19:339-353. PMID: 30216853

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2018 Oct;19:339-353. [Abstract]

Western blotting assay of AMPK, p-AMPK, PGC-1α, p-PGC-1α levels in nucleus pulposus (NP) cells stimulated with AGEs (200 μg/mL) in the presence or absence of A-769662 (50 μM), RAGE antibody (10 μg/mL), nicotinamide mononucleotide (NMN, 100 μM) or Compound C (50 uM).
Redox Biol

Regulation of AMPK-related glycolipid metabolism imbalances redox homeostasis and inhibits anchorage independent growth in human breast cancer cells. [Abstract]

2018 Jul;17:180-191. PMID: 29702405

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2018 Jul;17:180-191. [Abstract]

MDA-MB-231 cells are cultured in poly-HEMA coated dishes and treated with Compound C or GL-V9 for 36 h. The expression of AMPK and p-AMPK in Compound C treated cells are assayed by Western blotting.
J Control Release

Metabolic reprogramming mediated PD-L1 depression and hypoxia reversion to reactivate tumor therapy. [Abstract]

2022 Dec:352:793-812. PMID: 36343761
Gut Microbes

Creatine-mediated ferroptosis inhibition is involved in the intestinal radioprotection of daytime-restricted feeding. [Abstract]

2025 Dec;17(1):2489072. PMID: 40205678
Cell Rep Med

Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer. [Abstract]

2025 Jul 15;6(7):102211. PMID: 40609539
Cardiovasc Diabetol

Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway. [Abstract]

2022 Oct 11;21(1):205. PMID: 36221104
Pharmacol Res

Nrf2 and its dependent autophagy activation cooperatively counteract ferroptosis to alleviate acute liver injury. [Abstract]

2023 Jan:187:106563. PMID: 36410674
Pharmacol Res

Lycorine improves peripheral nerve function by promoting Schwann cell autophagy via AMPK pathway activation and MMP9 downregulation in diabetic peripheral neuropathy. [Abstract]

2022 Jan:175:105985. PMID: 34863821
Pharmacol Res

Hyperoside relieves particulate matter-induced lung injury by inhibiting AMPK/mTOR-mediated autophagy deregulation. [Abstract]

2021 May:167:105561. PMID: 33737241
Pharmacol Res

DT-13 induced apoptosis and promoted differentiation of acute myeloid leukemia cells by activating AMPK-KLF2 pathway. [Abstract]

2020 Aug;158:104864. PMID: 32416217
Cell Mol Biol Lett

IP3R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin. [Abstract]

2024 Feb 2;29(1):22. PMID: 38308199
Cell Mol Biol Lett

5-Methoxyflavone-induced AMPKα activation inhibits NF-κB and P38 MAPK signaling to attenuate influenza A virus-mediated inflammation and lung injury in vitro and in vivo. [Abstract]

2022 Sep 30;27(1):82. PMID: 36180831
Mater Today Bio

Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway. [Abstract]

2021 Oct 12:12:100147. PMID: 34704011
Cancer Lett

SLC5A11 mediates metformin-induced PD-L1 suppression to enhance cancer immunotherapy through AMPK-IRF1 signaling. [Abstract]

2026 Apr 28:644:218311. PMID: 41690450
Cancer Lett

Fusobacterium nucleatum enhances cholesterol biosynthesis in colorectal cancer via miR-130a-3p-mediated AMPK inhibition, a process counteracted by butyrate. [Abstract]

2025 May 23:217810. PMID: 40414519
Cancer Lett

6-Phosphogluconate dehydrogenase promotes glycolysis and fatty acid synthesis by inhibiting the AMPK pathway in lung adenocarcinoma cells. [Abstract]

2024 Aug 21:217177. PMID: 39179096
Cancer Lett

Targeting TAM-secreted S100A9 effectively enhances the tumor-suppressive effect of metformin in treating lung adenocarcinoma. [Abstract]

2024 Jan 28:581:216497. PMID: 38008395
J Neuroinflammation

Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage. [Abstract]

2020 May 25;17(1):165. PMID: 32450897
Cancer Lett

FOXM1 contributes to docetaxel resistance in castration-resistant prostate cancer by inducing AMPK/mTOR-mediated autophagy. [Abstract]

2020 Jan 28;469:481-489. PMID: 31738958
Int J Biol Sci

Heterophyllin B enhances transcription factor EB-mediated autophagy and alleviates pyroptosis and oxidative stress after spinal cord injury. [Abstract]

2024 Oct 7;20(14):5415-5435. PMID: 39494322
Int J Biol Sci

Irisin attenuates vascular remodeling in hypertensive mice induced by Ang II by suppressing Ca2+-dependent endoplasmic reticulum stress in VSMCs. [Abstract]

2024 Jan 1;20(2):680-700. PMID: 38169582
Int J Biol Sci

High Glucose Accelerates Tumor Progression by Regulating MEDAG-Mediated Autophagy Levels in Breast Cancer. [Abstract]

2022 Jul 4;18(11):4289-4300. PMID: 35864962
Int J Biol Sci

Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway. [Abstract]

2021 Mar 11;17(4):1138-1152. PMID: 33867836
Int J Biol Sci

Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway. [Abstract]

2019 Jan 1;15(2):325-340. PMID: 30745824
Cell Death Dis

AKT1 phosphorylates PRMT7 to promote GLUD1 methylation and gastric cancer progression. [Abstract]

2026 Mar 24;17(1):363. PMID: 41876450
Adv Healthc Mater

Near-Infrared-II Photothermal Agents Targeting Lipid Droplets to Ameliorate Obesity Through Induction of Adipose Tissue Browning. [Abstract]

2026 Apr;15(16):e04999. PMID: 41691427
Adv Healthc Mater

3D Printed Microsphere-Hydrogel Scaffold Facilitates Restoration of Reinnervation in Bone Regeneration through Programmable Release of NGF/BMP-2 Mimetic Peptides. [Abstract]

2025 Jun 4:e2501594. PMID: 40468637
Cell Death Dis

Irisin regulates oxidative stress and mitochondrial dysfunction through the UCP2-AMPK pathway in prion diseases. [Abstract]

2025 Feb 3;16(1):66. PMID: 39900919
Cell Death Dis

LncRNA PVT1 induces mitochondrial dysfunction of podocytes via TRIM56 in diabetic kidney disease. [Abstract]

2024 Sep 30;15(9):697. PMID: 39349450
Cell Death Dis

Dehydroepiandrosterone exacerbates nigericin-induced abnormal autophagy and pyroptosis via GPER activation in LPS-primed macrophages. [Abstract]

2022 Apr 19;13(4):372. PMID: 35440074
Cell Death Dis

FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival. [Abstract]

2019 Nov 18;10(12):872. PMID: 31740658
Cell Death Dis

4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. [Abstract]

2019 Jul 8;10(7):525. PMID: 31285420
Cell Death Dis

Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways. [Abstract]

2019 Feb 13;10(2):142. PMID: 30760707
Cell Death Dis

Betulin exhibits anti-inflammatory activity in LPS-stimulated macrophages and endotoxin-shocked mice through an AMPK/AKT/Nrf2-dependent mechanism. [Abstract]

2017 May 18;8(5):e2798. PMID: 28518138

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2017 May 18;8(5):e2798. [Abstract]

Involvement of the AMPK/AKT/GSK3β pathway in Nrf2 nuclear translocation by Betulin. Cells are treated with 3 μM compound C (Comp.C) for 18 h before treatment with betulin (36 μM) for 6 h. Cell lysates are immunoblotted for the phosphorylation of AMPK, Akt, GSK3β and Nrf2.
Cell Commun Signal

Inhibition of SGLT2 protects podocytes in diabetic kidney disease by rebalancing mitochondria-associated endoplasmic reticulum membranes. [Abstract]

2024 Nov 7;22(1):534. PMID: 39511548
Cell Commun Signal

Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF. [Abstract]

2024 Jun 3;22(1):306. PMID: 38831454
J Pharm Anal

Metformin: A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation. [Abstract]

2024 Jan;14(1):52-68. PMID: 38352949
Cell Commun Signal

Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy. [Abstract]

2023 May 4;21(1):99. PMID: 37143083
Cell Commun Signal

Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth. [Abstract]

2022 Jul 16;20(1):105. PMID: 35842652
Int J Biol Macromol

A novel long non-coding RNA, Lnc-GAS7, modulates myosin heavy chain isoform switching via AMPK signaling in ovine muscle. [Abstract]

2025 Oct 12;330(Pt 4):148291. PMID: 41086893
Int J Biol Macromol

Hepatoprotective effects of polysaccharide from Morchella esculenta are associated with activation of the AMPK/Sirt1 signaling pathway in mice with NAFLD. [Abstract]

2025 Jan 28:140444. PMID: 39884630
Int J Biol Macromol

Glutamate molecular structure and protein affect the inhibition of breast cancer cell metastasis: Cell-derived exosomes inhibitory effects through the MAPK signaling pathway. [Abstract]

2025 Jan 23:140264. PMID: 39863225
Acta Pharmacol Sin

Hepatocyte cellular repressor of E1A-stimulated genes 1 protects against acetaminophen-induced liver injury by promoting autophagy. [Abstract]

2025 Mar 25. PMID: 40133627
Acta Pharmacol Sin

Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway. [Abstract]

2021 Dec;42(12):2069-2081. PMID: 34417573
Phytomedicine

Cyasterone regulates lipid metabolism and autophagy mediated by the AMPK signaling pathway to improve KOA synovitis. [Abstract]

2026 Apr:153:157937. PMID: 41687535
Phytomedicine

The liver kinase B1 mediates the therapeutic efficacy of nuciferine against hepatic lipid accumulation in diabetic KKAy mice. [Abstract]

2026 Mar:152:157807. PMID: 41650502
Phytomedicine

Morus alba L. (Sangzhi) alkaloids alleviate diabetic nephropathy by suppressing endoplasmic reticulum stress and modulating AMPK-associated phosphatidylethanolamine content. [Abstract]

2026 Mar:152:157836. PMID: 41570782
Phytomedicine

2025 Dec 28.
Phytomedicine

Novel dual AMPK/NRF2 activation by leucocyanidin from Hawthorn (Crataegus) for mitochondria repair-Targeted therapy of hepatic steatosis. [Abstract]

2025 Nov 27:150:157614. PMID: 41365192
Phytomedicine

Siweixizangmaoru decoction attenuates collagen-induced arthritis via gut microbiota-dependent SCFA restoration and immunomodulation. [Abstract]

2025 Sep 9:148:157249. PMID: 40946662
Phytomedicine

Keluoxin reduces renal lipid deposition in diabetic nephropathy via AMPK/NF-κB-mediated mtabolic regulation. [Abstract]

2025 May 19:145:156776. PMID: 40578033
Phytomedicine

Swiprosin-1 participates in the berberine-regulated AMPK/MLCK pathway to attenuate colitis-induced tight junction damage. [Abstract]

2024 Dec:135:156111. PMID: 39369569
Phytomedicine

Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction. [Abstract]

2024 Jun:128:155529. PMID: 38503156
Phytomedicine

Isolation of Calenduloside E from Achyranthes bidentata Blume and its effects on LPS/D-GalN-induced acute liver injury in mice by regulating the AMPK-SIRT3 signaling pathway. [Abstract]

2024 Mar:125:155353. PMID: 38241918
Phytomedicine

Chlorogenic acid regulates the expression of NPC1L1 and HMGCR through PXR and SREBP2 signaling pathways and their interactions with HSP90 to maintain cholesterol homeostasis. [Abstract]

2024 Jan:123:155271. PMID: 38103317
Phytomedicine

The protective effects of icariin against testicular dysfunction in type 1 diabetic mice Via AMPK-mediated Nrf2 activation and NF-κB p65 inhibition. [Abstract]

2024 Jan:123:155217. PMID: 37992492
Phytomedicine

Si-Ni-San inhibits hepatic Fasn expression and lipid accumulation in MAFLD mice through AMPK/p300/SREBP-1c axis. [Abstract]

2024 Jan:123:155209. PMID: 37984123
Phytomedicine

Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis. [Abstract]

2023 Feb:110:154640. PMID: 36608498
Phytomedicine

Dihydromyricetin protects against Doxorubicin-induced cardiotoxicity through activation of AMPK/mTOR pathway. [Abstract]

2022 May:99:154027. PMID: 35278898
Phytomedicine

Arctium lappa L. roots ameliorates cerebral ischemia through inhibiting neuronal apoptosis and suppressing AMPK/mTOR-mediated autophagy. [Abstract]

2021 May:85:153526. PMID: 33691269
Phytomedicine

Daphnetin triggers ROS-induced cell death and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway in ovarian cancer. [Abstract]

2021 Feb:82:153465. PMID: 33486268
Phytomedicine

Hyperoside suppresses hypoxia-induced A549 survival and proliferation through ferrous accumulation via AMPK/HO-1 axis. [Abstract]

2020 Feb;67:153138. PMID: 31881478
Phytomedicine

Rubrofusarin-6-β-gentiobioside inhibits lipid accumulation and weight gain by regulating AMPK/mTOR signaling. [Abstract]

2019 Sep:62:152952. PMID: 31132754
Free Radic Biol Med

CD44-targeted chitosan nanoparticles delivering ginsenoside Rg1 restore mitochondrial homeostasis in diabetic kidney disease via AMPK/mTOR-mediated regulation of autophagy and pyroptosis. [Abstract]

2026 May:248:537-553. PMID: 41707746
Free Radic Biol Med

Paeoniflorin mitigates myocardial hypertrophy by regulating mitophagy and ferroptosis mediated by mitochondria-associated AMPK-Parkin-ACSL4 pathway. [Abstract]

2025 Dec 22:245:98-114. PMID: 41443335
Free Radic Biol Med

V8, a lysosomotropic wogonin derivative, alleviates hepatic steatosis by modulating GDF15-dependent mitochondrial homeostasis. [Abstract]

2025 Oct 23:S0891-5849(25)01299-7. PMID: 41138960
Free Radic Biol Med

ENO1 blockade augment ferroptosis susceptibility in TKIs-resistant CML through GPX4 autophagic degradation. [Abstract]

2025 Sep 19:S0891-5849(25)00942-6. PMID: 40976411
NPJ Parkinsons Dis

Disruption of axonal transport in Parkinson's disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling. [Abstract]

2025 May 6;11(1):114. PMID: 40328804
Free Radic Biol Med

Intermedin protects peritubular capillaries by inhibiting eNOS uncoupling through AMPK/GTPCH-I/BH4 pathway and alleviate CKD following AKI. [Abstract]

2025 Apr 12:S0891-5849(25)00225-4. PMID: 40228707
Free Radic Biol Med

TRPA1 protects against contrast-induced renal tubular injury by preserving mitochondrial dynamics via the AMPK/DRP1 pathway. [Abstract]

2024 Sep 13:S0891-5849(24)00659-2. PMID: 39278575
Free Radic Biol Med

Epithelial Piezo1 deletion ameliorates intestinal barrier damage by regulating ferroptosis in ulcerative colitis. [Abstract]

2024 Aug 29:S0891-5849(24)00633-6. PMID: 39216559
Free Radic Biol Med

Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy. [Abstract]

2023 Nov 1:208:319-333. PMID: 37640169
Free Radic Biol Med

Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK/NRF2 pathway. [Abstract]

2023 Feb 1:195:89-102. PMID: 36581059
Free Radic Biol Med

Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration via the AMPK signaling pathway. [Abstract]

2020 Apr:150:109-119. PMID: 32105828
Free Radic Biol Med

Clusterin ameliorates endothelial dysfunction in diabetes by suppressing mitochondrial fragmentation. [Abstract]

2019 Dec;145:357-373. PMID: 31614179
Free Radic Biol Med

Nrf2-mediated liver protection by esculentoside A against acetaminophen toxicity through the AMPK/Akt/GSK3β pathway. [Abstract]

2016 Dec:101:401-412. PMID: 27836781

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2016 Dec:101:401-412. [Abstract]

Effect of EsA on AMPK activation is necessary for AKT/GSK3β-mediated Nrf2 activity and cytoprotection. Cells are treated with 3 μM Compound C for 18 h, followed by treatment with EsA for 6 h, and then cell lysates are immunoblotted to assess the phosphorylation of AMPK, Akt and GSK3β and Nrf2.
Tumour Virus Res

Ad-VT oncolytic adenovirus suppresses bladder cancer via cAMP-dependent AMPK-Raptor activation and G2/M arrest. [Abstract]

2026 Jan 29:200337. PMID: 41619809
Apoptosis

Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated intervertebral disc degeneration in vivo. [Abstract]

2022 Dec;27(11-12):1031-1048. PMID: 36125665
Chemosphere

Microcystin-leucine-arginine induces apical ectoplasmic specialization disassembly. [Abstract]

2021 Feb;264(Pt 1):128440. PMID: 33002802
Chemosphere

Aflatoxin B1 impairs leydig cells through inhibiting AMPK/mTOR-mediated autophagy flux pathway. [Abstract]

2019 Oct:233:261-272. PMID: 31176127
Food Res Int

Quercetin alleviates ethanol-induced hepatocyte senescence by interacting with glycinamide ribonucleotide transformylase. [Abstract]

2025 Dec;221(Pt 3):117392. PMID: 41215006
NPJ Precis Oncol

Modulating ovarian cancer progression through FDX1-driven autophagy. [Abstract]

2025 Jul 8;9(1):230. PMID: 40629130
Food Res Int

Quercetin 3-O-glucuronide-rich lotus leaf extract promotes a Brown-fat-phenotype in C3H10T1/2 mesenchymal stem cells. [Abstract]

2023 Jan:163:112198. PMID: 36596137
Sci Total Environ

Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons. [Abstract]

2020 Feb 10;703:134702. PMID: 31753492
Br J Pharmacol

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule-based mitochondrial transport disorder to morphine tolerance. [Abstract]

2025 May 13. PMID: 40361281
Environ Res

Chronic microcystin-leucine-arginine exposure induces osteoporosis by breaking the balance of osteoblasts and osteoclasts. [Abstract]

2024 Oct 2;263(Pt 2):120098. PMID: 39366441
Br J Pharmacol

DADLE promotes motor function recovery by inhibiting cytosolic phospholipase A2 mediated lysosomal membrane permeabilization after spinal cord injury. [Abstract]

2024 Mar;181(5):712-734. PMID: 37766498
Brain Behav Immun

Autophagy activated by the AMPK/mTOR/ULK1 pathway involves AURKB-mediated microgliosis in neuropathic pain. [Abstract]

2025 Oct:129:948-959. PMID: 40721174
Alzheimers Res Ther

Delphinidin attenuates cognitive deficits and pathology of Alzheimer's disease by preventing microglial senescence via AMPK/SIRT1 pathway. [Abstract]

2025 Jun 20;17(1):138. PMID: 40542425
Alzheimers Res Ther

Photobiomodulation mitigates blood-brain barrier disruption in APP/PS1 mouse model of Alzheimer's disease by activating the AMPK pathway. [Abstract]

2025 Jun 23;17(1):141. PMID: 40551167
J Transl Med

Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization. [Abstract]

2025 Jul 18;23(1):805. PMID: 40682116
Biomed Pharmacother

The mechanism of patchouli alcohol in treating IBS-D based on BMP-Smad pathway. [Abstract]

2025 Apr 22:187:118050. PMID: 40267641
J Transl Med

Chemically synthesized osteocalcin alleviates NAFLD via the AMPK-FOXO1/BCL6-CD36 pathway. [Abstract]

2024 Aug 22;22(1):782. PMID: 39175012
Biomed Pharmacother

Melatonin regulates microglial M1/M2 polarization via AMPKα2-mediated mitophagy in attenuating sepsis-associated encephalopathy. [Abstract]

2024 Jul 7:177:117092. PMID: 38976956
Biomed Pharmacother

Pseudolaric acid B suppresses NSCLC progression through the ROS/AMPK/mTOR/autophagy signalling pathway. [Abstract]

2024 Jun:175:116614. PMID: 38670047
Biomed Pharmacother

Maximakinin reversed H2O2 induced oxidative damage in rat cardiac H9c2 cells through AMPK/Akt and AMPK/ERK1/2 signaling pathways. [Abstract]

2024 May:174:116489. PMID: 38513595
Biomed Pharmacother

6-Gingerol regulates triglyceride and cholesterol biosynthesis to improve hepatic steatosis in MAFLD by activating the AMPK-SREBPs signaling pathway. [Abstract]

2024 Jan:170:116060. PMID: 38147735
Biomed Pharmacother

Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK/GSK3β(Ser9)/Nrf2 signaling pathway. [Abstract]

2023 Dec 31:169:115909. PMID: 37992573
Arch Pharm Res

2-Geranyl-1-methoxyerythrabyssin II alleviates lipid accumulation and inflammation in hepatocytes through AMPK activation and AKT inhibition. [Abstract]

2023 Oct;46(9-10):808-824. PMID: 37782374
Biomed Pharmacother

CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress. [Abstract]

2023 Oct:166:115399. PMID: 37657258
Diabetes

Metrnl alleviates lipid accumulation by modulating mitochondrial homeostasis in diabetic nephropathy. [Abstract]

2023 May 1;72(5):611-626. PMID: 36812572
Biomed Pharmacother

Naringenin promoted spinal microglia M2 polarization in rat model of cancer-induced bone pain via regulating AMPK/PGC-1α signaling axis. [Abstract]

2022 May:149:112912. PMID: 35856853
Biomed Pharmacother

Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy. [Abstract]

2022 May 10;151:113092. PMID: 35550528
Biomed Pharmacother

An integrative strategy for discovery of functional compound combination from Traditional Chinese Medicine: Danhong Injection as a model. [Abstract]

2021 Jun;138:111451. PMID: 33714107
Biomed Pharmacother

d-Mannose suppresses osteoarthritis development in vivo and delays IL-1β-induced degeneration in vitro by enhancing autophagy activated via the AMPK pathway. [Abstract]

2021 Mar:135:111199. PMID: 33401221
Diabetes

DW14006 as a Direct AMPKα Activator Ameliorates Diabetic Peripheral Neuropathy in Mice. [Abstract]

2020 Sep;69(9):1974-1988. PMID: 32647036
Biomed Pharmacother

Anti-hypertrophy effect of atorvastatin on myocardium depends on AMPK activation-induced miR-143-3p suppression via Foxo1. [Abstract]

2018 Oct:106:1390-1395. PMID: 30119211

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Oct:106:1390-1395. [Abstract]

Effect of Compound C on cell viability, cell surface area, and apoptosis in Ang II-treated H9c2 cells.

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Oct:106:1390-1395. [Abstract]

Effect of Compound C on the AMPK/Foxo1/miR-143-3p axis in Ang II-treated H9c2 cells.
Biomed Pharmacother

Two sesquiterpene aminoquinones protect against oxidative injury in HaCaT keratinocytes via activation of AMPKα/ERK-Nrf2/ARE/HO-1 signaling. [Abstract]

2018 Apr:100:417-425. PMID: 29471244

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Apr:100:417-425. [Abstract]

HaCaT cells are pre-incubated with Compound C (CC) (10 μM) and U0126 (10 μM), pharmacological inhibitors of AMPKα, ERK, respectively, for 1 h before treatment with DA8 and DA14 (DAs).
Europace

Promoting differentiation of human-induced pluripotent stem cells into sinoatrial node-like cells through programmed regulation of AMPK signalling pathway. [Abstract]

2025 Oct 31;27(11):euaf288. PMID: 41206581
Diabetes Res Clin Pract

Thioredoxin upregulation delays diabetes-induced photoreceptor cell degeneration via AMPK-mediated autophagy and exosome secretion. [Abstract]

2022 Mar:185:109788. PMID: 35182712
Stem Cell Res Ther

Linolamide in apoptotic bodies: a key factor in mesenchymal stem cell immunotherapy for two abortion models. [Abstract]

2025 Oct 1;16(1):537. PMID: 41035048
Stem Cell Res Ther

The role of PKM2-mediated metabolic reprogramming in the osteogenic differentiation of BMSCs under diabetic periodontitis conditions. [Abstract]

2025 Apr 18;16(1):186. PMID: 40251642
Stem Cell Res Ther

Nano-zinc oxide (nZnO) targets the AMPK-ULK1 pathway to promote bone regeneration. [Abstract]

2025 Apr 24;16(1):206. PMID: 40275329
Oncogene

The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation. [Abstract]

2025 May;44(16):1078-1092. PMID: 39865175
Stem Cell Res Ther

Stable expression of a truncated TLX variant drives differentiation of induced pluripotent stem cells into self-renewing neural stem cells for production of extracellular vesicles. [Abstract]

2022 Sep 2;13(1):436. PMID: 36056423
Stem Cell Res Ther

Adipose-derived mesenchymal stromal cell-derived exosomes promote tendon healing by activating both SMAD1/5/9 and SMAD2/3. [Abstract]

2021 Jun 10;12(1):338. PMID: 34112236
Oncogene

Antifungal agent Terbinafine restrains tumor growth in preclinical models of hepatocellular carcinoma via AMPK-mTOR axis. [Abstract]

2021 Aug;40(34):5302-5313. PMID: 34247189
Environ Pollut

Resveratrol prevents benzo(a)pyrene-induced disruption of mitochondrial homeostasis via the AMPK signaling pathway in primary cultured neurons. [Abstract]

2020 Jun;261:114207. PMID: 32220751
Aging Cell

Dietary Citrate Restores Age-Related Endothelial Cell Mitochondrial Dysfunction and Alleviates Atherosclerosis. [Abstract]

2025 Oct;24(10):e70213. PMID: 40905413
Aging Cell

CAV1 Exacerbates Renal Tubular Epithelial Cell Senescence by Suppressing CaMKK2/AMPK-Mediated Autophagy. [Abstract]

2025 Jan 30:e14501. PMID: 39887553
Aging Cell

β-Hydroxybutyrate enhances chondrocyte mitophagy and reduces cartilage degeneration in osteoarthritis via the HCAR2/AMPK/PINK1/Parkin pathway. [Abstract]

2024 Aug 9:e14294. PMID: 39126207
Cell Death Discov

Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer. [Abstract]

2025 Apr 4;11(1):139. PMID: 40180904
Curr Res Food Sci

Dietary kaempferol exerts anti-obesity effects by inducing the browing of white adipocytes via the AMPK/SIRT1/PGC-1α signaling pathway. [Abstract]

2024 Mar 28:8:100728. PMID: 38577419
Cell Death Discov

Bak instead of Bax plays a key role in metformin-induced apoptosis s in HCT116 cells. [Abstract]

2021 Nov 22;7(1):363. PMID: 34811352
Cell Rep

ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA. [Abstract]

2025 Jun 13;44(6):115851. PMID: 40516055
Cell Rep

RNA m6A dynamics promote transcription and RNA stability of bivalent genes during iPSC-induced generation of human lung progenitors. [Abstract]

2025 Jun 6;44(6):115802. PMID: 40483690
Cell Rep

The metabolic sensor LKB1 regulates ILC3 homeostasis and mitochondrial function. [Abstract]

2025 Mar 21;44(4):115456. PMID: 40120107
Cell Rep

Adiponectin receptor 1-mediated basolateral amygdala-prelimbic cortex circuit regulates methamphetamine-associated memory. [Abstract]

2024 Dec 10;43(12):115074. PMID: 39661515
Neurotherapeutics

2023 Dec 19, e00305.
Cell Rep

Resolvin D1 reprograms energy metabolism to promote microglia to phagocytize neutrophils after ischemic stroke. [Abstract]

2023 Jun 6;42(6):112617. PMID: 37285269
Cell Rep

Chemical-induced epigenome resetting for regeneration program activation in human cells. [Abstract]

2023 May 23;42(6):112547. PMID: 37224020
Cell Rep

circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells. [Abstract]

2022 Nov 22;41(8):111707. PMID: 36417875
Cell Rep

Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex. [Abstract]

2022 Oct 18;41(3):111498. PMID: 36261001
Clin Transl Med

CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post-translational modification. [Abstract]

2023 Jan;13(1):e1158. PMID: 36604982
Clin Transl Med

Low-glucose-sensitive TRPC6 dysfunction drives hypoglycemia-induced cognitive impairment in diabetes. [Abstract]

2020 Oct;10(6):e205. PMID: 33135341
Neural Regen Res

Hedgehog signaling activation rescues hypoxia-induced ferroptosis in human brain organoids. [Abstract]

2025 Sep 29. PMID: 41017694
Neural Regen Res

Trans-spinal magnetic stimulation attenuates neuropathic pain caused by spinal cord injury. [Abstract]

2025 Apr 29. PMID: 40313090
Neural Regen Res

Bexarotene improves motor function after spinal cord injury in mice. [Abstract]

2023 Dec;18(12):2733-2742. PMID: 37449638
Neural Regen Res

Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5'-monophosphate-activated protein kinase/heme oxygenase-1 pathway. [Abstract]

2023 Sep;18(9):2067-2074. PMID: 36926733
Antioxidants (Basel)

Pulsatilla Saponin B4 Alleviates H2O2-Induced Oxidative Stress and Apoptosis via the AMPK/Nrf2 Pathway in Bovine Mammary Epithelial Cell Models. [Abstract]

2026 Feb 27;15(3):294. PMID: 41897441
Antioxidants (Basel)

β-Nicotinamide Mononucleotide Reduces Oxidative Stress and Improves Steroidogenesis in Granulosa Cells Associated with Sheep Prolificacy via Activating AMPK Pathway. [Abstract]

2024 Dec 30;14(1):34. PMID: 39857368
Antioxidants (Basel)

Ginsenoside Rg1 Alleviates Blood-Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy. [Abstract]

2024 Nov 24;13(12):1446. PMID: 39765775
Antioxidants (Basel)

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Ameliorate Aging-Induced BTB Impairment in Porcine Testes by Activating Autophagy and Inhibiting ROS/NLRP3 Inflammasomes via the AMPK/mTOR Signaling Pathway. [Abstract]

2024 Jan 31;13(2):183. PMID: 38397781
Antioxidants (Basel)

Serelaxin Protects H9c2 Cardiac Myoblasts against Hypoxia and Reoxygenation-Induced Damage through Activation of AMP Kinase/Sirtuin1: Further Insight into the Molecular Mechanisms of the Cardioprotection of This Hormone. [Abstract]

2024 Jan 27;13(2):163. PMID: 38397761
J Anim Sci Biotechnol

Vitamin A-activated PPARγ signaling enhances intramuscular fat accumulation by overriding AMPK-mediated inhibition in late-fattening beef cattle. [Abstract]

2026 Feb 12;17(1):29. PMID: 41673695
Int J Nanomedicine

Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway. [Abstract]

2024 Oct 25:19:10839-10856. PMID: 39479173
J Anim Sci Biotechnol

Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway. [Abstract]

2024 Sep 5;15(1):119. PMID: 39232832
Mol Med

CAMKK2 restored mitochondrial dynamics homeostasis to alleviate pulmonary fibrosis via AMPK/PGC-1α signaling pathway in lung fibroblasts. [Abstract]

2025 Oct 6;31(1):308. PMID: 41053564
Mol Med

Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes cerebral ischemic injury via facilitating mitochondrial fission. [Abstract]

2024 Oct 10;30(1):173. PMID: 39390372
Mol Med

Liraglutide attenuates type 2 diabetes mellitus-associated non-alcoholic fatty liver disease by activating AMPK/ACC signaling and inhibiting ferroptosis. [Abstract]

2023 Sep 28;29(1):132. PMID: 37770820
Mol Med

Fibroblast growth factor 21 attenuates salt-sensitive hypertension-induced nephropathy through anti-inflammation and anti-oxidation mechanism. [Abstract]

2021 Nov 13;27(1):147. PMID: 34773993
Oncogenesis

Fatty acid transport protein-5 (FATP5) deficiency enhances hepatocellular carcinoma progression and metastasis by reprogramming cellular energy metabolism and regulating the AMPK-mTOR signaling pathway. [Abstract]

2021 Nov 12;10(11):74. PMID: 34772914
Phytother Res

Costunolide Ameliorates Hepatic Steatosis and Insulin Resistance in a Diet-Induced Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK/ACC1 Signalling Pathway. [Abstract]

2026 Mar 17. PMID: 41843424
Phytother Res

Genistein Ameliorates the Ischemic State of Random Skin Flap by Regulating Macrophage Polarization Through AMPK/SIRT1 Signaling Pathway. [Abstract]

2025 Dec 2. PMID: 41331137
Phytother Res

Xanthohumol Regulates Mitophagy in Osteosarcoma Cells via AMPK-ULK1-FUNDC1 Signaling Pathway. [Abstract]

2025 May;39(5):2393-2406. PMID: 40190139
Phytother Res

Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis. [Abstract]

2024 Jun;38(6):3020-3036. PMID: 38600729
Phytother Res

Baicalin promotes random-pattern skin flap survival by inducing autophagy via AMPK-regulated TFEB nuclear transcription. [Abstract]

2023 Sep;37(9):3926-3938. PMID: 37291961
Phytother Res

Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway. [Abstract]

2023 Jul;37(7):3025-3041. PMID: 36879478
Phytother Res

Ginkgo biloba extract protects against diabetic cardiomyopathy by restoring autophagy via adenosine monophosphate-activated protein kinase/mammalian target of the rapamycin pathway modulation. [Abstract]

2023 Apr;37(4):1377-1390. PMID: 36751963
Phytother Res

Eugenol promotes appetite through TRP channels mediated-CaMKK2/AMPK signaling pathway. [Abstract]

2023 Jul;37(7):2759-2770. PMID: 36762415
Phytother Res

Aqueous extract of clove inhibits tumor growth by inducing autophagy through AMPK/ULK pathway. [Abstract]

2019 Jul;33(7):1794-1804. PMID: 30993793
J Agric Food Chem

Foodborne PET Microplastic Contamination Compromises Intestinal Barrier through a Mitochondrial-AMPK-DNA Damage Pathway. [Abstract]

2026 Feb 18;74(6):5718-5730. PMID: 41657037
J Agric Food Chem

Orally Administered Neohesperidin (Neo) Alleviates Lipopolysaccharide-Induced Mastitis by Suppressing TLR4/NF-κB and Activating AMPK/Nrf2/HO-1 Signaling, and Regulating Intestinal Flora Structure. [Abstract]

2026 Jan 21;74(2):2140-2156. PMID: 41506296
J Agric Food Chem

AFG Ameliorates Diabetic Retinopathy through AMPK-Dependent Autolysosomal Pathway: From Network Pharmacology to In Vivo and In Vitro Validation. [Abstract]

2026 Jan 21;74(2):2124-2139. PMID: 41493960
EMBO Rep

CTRP9 engages AdipoR1 and promotes T cell glycolysis and immunity. [Abstract]

2025 Nov 17. PMID: 41249580
J Agric Food Chem

Tricin Delays Aging and Enhances Muscle Function via Activating AMPK-Mediated Autophagy in Diverse Model Organisms. [Abstract]

2025 Apr 30;73(17):10246-10264. PMID: 40243450
Cell Mol Life Sci

Acetyl-CoA synthetase 2 alleviates brain injury following cardiac arrest by promoting autophagy in brain microvascular endothelial cells. [Abstract]

2025 Apr 17;82(1):160. PMID: 40244361
J Agric Food Chem

Therapeutic Potential of Raspberry Extract in High-Fat Diet-Induced Liver Injury via Apoptosis and AMPK/PPARα Pathways. [Abstract]

2025 Apr 1. PMID: 40168586
J Agric Food Chem

Platycodin D Ameliorates Type 2 Diabetes-Induced Myocardial Injury by Activating the AMPK Signaling Pathway. [Abstract]

2024 May 8;72(18):10339-10354. PMID: 38682702
Cell Biosci

Remote ischemic preconditioning protects against spinal cord ischemia-reperfusion injury in mice by activating NMDAR/AMPK/PGC-1α/SIRT3 signaling. [Abstract]

2023 Mar 16;13(1):57. PMID: 36927808
J Agric Food Chem

Gut-Derived Metabolites from Dietary Tryptophan Supplementation Quench Intestinal Inflammation through the AMPK-SIRT1-Autophagy Pathway. [Abstract]

2022 Dec 28;70(51):16080-16095. PMID: 36521060
J Agric Food Chem

Sesamin Activates Skeletal Muscle FNDC5 Expression and Increases Irisin Secretion via the SIRT1 Signaling Pathway. [Abstract]

2022 Jun 29;70(25):7704-7715. PMID: 35708276
J Agric Food Chem

Tryptophan Promotes Intestinal Immune Defense through Calcium-Sensing Receptor (CaSR)-Dependent Metabolic Pathways. [Abstract]

2021 Nov 17;69(45):13460-13473. PMID: 34748328
J Agric Food Chem

Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice. [Abstract]

2021 May 26;69(20):5618-5627. PMID: 33979145
J Agric Food Chem

Cinnamtannin D1 Protects Pancreatic β-Cells from Glucolipotoxicity-Induced Apoptosis by Enhancement of Autophagy In Vitro and In Vivo. [Abstract]

2020 Nov 11;68(45):12617-12630. PMID: 33125846
J Agric Food Chem

Protocatechuic Acid-Ameliorated Endothelial Oxidative Stress through Regulating Acetylation Level via CD36/AMPK Pathway. [Abstract]

2019 Jun 26;67(25):7060-7072. PMID: 31240928
J Agric Food Chem

Activation of Nrf2 by Phloretin Attenuates Palmitic Acid-Induced Endothelial Cell Oxidative Stress via AMPK-Dependent Signaling. [Abstract]

2019 Jan 9;67(1):120-131. PMID: 30525573
J Agric Food Chem

n-Butanol Extract of Lotus Seeds Exerts Antiobesity Effects in 3T3-L1 Preadipocytes and High-Fat Diet-Fed Mice via Activating Adenosine Monophosphate-Activated Protein Kinase. [Abstract]

2019 Jan 30;67(4):1092-1103. PMID: 30621393
J Agric Food Chem

Glutamine Deficiency Promotes PCV2 Infection through Induction of Autophagy via Activation of ROS-Mediated JAK2/STAT3 Signaling Pathway. [Abstract]

2018 Nov 7;66(44):11757-11766. PMID: 30343565

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2018 Nov 7;66(44):11757-11766. [Abstract]

The number of GFP-LC3 dots are reduced significantly after inhibiting STAT3 (AG-490) signaling.
J Agric Food Chem

Improvement of Lipid and Glucose Metabolism by Capsiate in Palmitic Acid-Treated HepG2 Cells via Activation of the AMPK/SIRT1 Signaling Pathway. [Abstract]

2018 Jul 5;66(26):6772-6781. PMID: 29886733

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2018 Jul 5;66(26):6772-6781. [Abstract]

Effects of Compound C on capsiate-treated HepG2 cells in high fat environment. The expressions of key metabolic regulators and lipid metabolism-related proteins are quantified by densitometry, and the relative intensities are expressed in the bar chart.

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2018 Jul 5;66(26):6772-6781. [Abstract]

Effects of Compound C on capsiate-treated HepG2 cells in high fat environment. The expressions of glucose metabolism-related proteins are quantified by densitometry, and the relative intensities are expressed in the bar chart.
J Agric Food Chem

d-Fagomine Attenuates High Glucose-Induced Endothelial Cell Oxidative Damage by Upregulating the Expression of PGC-1α. [Abstract]

2018 Mar 21;66(11):2758-2764. PMID: 29489344
Ecotoxicol Environ Saf

Lycopene inhibits zearalenone-induced ferroptosis via activating AMPK/Nrf2 signaling pathway in AML-12 hepatocytes and in mice livers. [Abstract]

2025 Sep 15:303:119045. PMID: 40945091
Ecotoxicol Environ Saf

PRKAA1 induces aberrant mitophagy in a PINK1/Parkin-dependent manner, contributing to fluoride-induced developmental neurotoxicity. [Abstract]

2023 Apr 15:255:114772. PMID: 36924562
JCI Insight

Ketone body β-hydroxybutyrate is an autophagy-dependent vasodilator. [Abstract]

2021 Oct 22;6(20):e149037. PMID: 34499623
Environ Sci Eur

2025 Mar 08.
Cell Biol Toxicol

Asperosaponin VI mitigates mitochondrial dysfunction and chondrocyte apoptosis in osteoarthritis by modulating the AMPK-SIRT3 pathway. [Abstract]

2025 Jul 24;41(1):120. PMID: 40702216
Food Biosci

2025 Aug.
Food Biosci

2025 Jan.
Cell Biol Toxicol

UHRF1 promotes calcium oxalate-induced renal fibrosis by renal lipid deposition via bridging AMPK dephosphorylation. [Abstract]

2025 Feb 3;41(1):39. PMID: 39899077
Cell Biol Toxicol

CTRP9 attenuates peripheral nerve injury-induced mechanical allodynia and thermal hyperalgesia through regulating spinal microglial polarization and neuroinflammation mediated by AdipoR1 in male mice. [Abstract]

2024 Oct 26;40(1):91. PMID: 39460844
Front Immunol

LPS Stimulation Induces Small Heterodimer Partner Expression Through the AMPK-NRF2 Pathway in Large Yellow Croaker (Larimichthys crocea). [Abstract]

2021 Nov 8:12:753681. PMID: 34819934
Front Immunol

Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling Axis. [Abstract]

2019 Nov 14;10:2650. PMID: 31798583
Int J Mol Med

Jinlida granules alleviate podocyte apoptosis and mitochondrial dysfunction via the AMPK/PGC‑1α pathway in diabetic nephropathy. [Abstract]

2025 Feb;55(2):26. PMID: 39670303
Int J Mol Med

Berberine inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via the RhoE/AMPK pathway. [Abstract]

2024 May;53(5):49. PMID: 38577949
Int J Mol Med

Sestrin‑2 regulates podocyte mitochondrial dysfunction and apoptosis under high‑glucose conditions via AMPK. [Abstract]

2020 May;45(5):1361-1372. PMID: 32323727
Int J Mol Med

High glucose suppresses the viability and proliferation of HTR‑8/SVneo cells through regulation of the miR‑137/PRKAA1/IL‑6 axis. [Abstract]

2018 Aug;42(2):799-810. PMID: 29786111
Int J Mol Med

AMP-activated protein kinase stimulates osteoblast differentiation and mineralization through autophagy induction. [Abstract]

2018 May;41(5):2535-2544. PMID: 29484369

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2018 May;41(5):2535-2544. [Abstract]

Cells are treated with AICAR and AICAR (A++, 10 μM) + Compound C (C++, 1 μM) for 24 h, after which western blot analysis is performed.
Diabetes Obes Metab

Adipose-Specific GHR Knockout Confers Multidimensional Anti-Aging Advantages via Adipose Tissue Remodelling and Enhanced Metabolic Elasticity. [Abstract]

2026 Jun;28(6):4741-4758. PMID: 41847844
Chin Med

Mechanistic insights into the Bushen Huatan Huoxue Formula and its components in ameliorating obesity-associated polycystic ovary syndrome. [Abstract]

2025 Jul 1;20(1):99. PMID: 40597295
Chin Med

Pedunculoside alleviates cognitive deficits and neuronal cell apoptosis by activating the AMPK signaling cascade. [Abstract]

2024 Nov 22;19(1):163. PMID: 39574131
Chin Med

Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to ameliorate cardiotoxicity. [Abstract]

2024 Jun 14;19(1):85. PMID: 38877519
Biochem Pharmacol

Cichoriin suppresses hepatic lipid accumulation and fibrosis in mice metabolic dysfunction associated steatohepatitis via the AMPK pathway. [Abstract]

2025 Dec 10:245:117630. PMID: 41386558
Biochem Pharmacol

Glimepiride overcomes acquired resistance to EGFR TKIs in lung cancer via the AMPK/ERK/MMP7 signaling pathway. [Abstract]

2025 Jul 12:241:117162. PMID: 40659128
Cell Prolif

Inhibition of deubiquitination by PR-619 induces apoptosis and autophagy via ubi-protein aggregation-activated ER stress in oesophageal squamous cell carcinoma. [Abstract]

2021 Jan;54(1):e12919. PMID: 33129231
Cell Prolif

Ginsenoside Rb3 provides protective effects against cisplatin-induced nephrotoxicity via regulation of AMPK-/mTOR-mediated autophagy and inhibition of apoptosis in vitro and in vivo. [Abstract]

2019 Jul;52(4):e12627. PMID: 31094028
Biochem Pharmacol

Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase. [Abstract]

2017 Aug 15:138:49-60. PMID: 28528695

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2017 Aug 15:138:49-60. [Abstract]

Blockade of AMPK signals by AMPK α2 siRNA or AMPK inhibitor (Dorsomorphin; 2.5 μM, pretreatment 2 hours) treatment counteracts the apoptotic effects of Cantharidin at 2.5 μM. Data are representative of at least two independent experiments. Blocking AMPK signaling by knockdown of AMPK or Dorsomorphin (AMPK kinase inhibitor) treatment markedly reverses the apoptotic effect of Cantharidin, indicating that AMPK activation is required for the anti-HCC activity of Cantharidin.
Biochem Pharmacol

Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation. [Abstract]

2016 Dec 15:122:42-61. PMID: 27816546

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2016 Dec 15:122:42-61. [Abstract]

HepG2 cells were incubated with or without Compound C (Dorsomorphin) for 1 h, the cells were switched to medium D in the presence of vehicle, or AHI.
Am J Chin Med

Unraveling the Mechanisms of Active Saponins from Rhizoma Anemarrhenae Against Ferroptosis in Alzheimer's Disease: Integrating Network Pharmacology, Cell Membrane Chromatography, and Experimental Validation. [Abstract]

2025;53(4):1119-1154. PMID: 40582724
Am J Chin Med

Smilax china Polyphenols Stimulate Browning via [Formula: see text]3-Adrenergic Receptor/AMP-Activated Protein Kinase [Formula: see text] Signaling Pathway in 3T3-L1 Adipocytes. [Abstract]

2022;50(5):1315-1329. PMID: 35642460
Am J Chin Med

Using Network Pharmacology for Systematic Understanding of Geniposide in Ameliorating Inflammatory Responses in Colitis Through Suppression of NLRP3 Inflammasome in Macrophage by AMPK/Sirt1 Dependent Signaling. [Abstract]

2020;48(7):1693-1713. PMID: 33202149
Am J Chin Med

Baicalein Induces Autophagy and Apoptosis through AMPK Pathway in Human Glioma Cells. [Abstract]

2019;47(6):1405-1418. PMID: 31488033
ACS Biomater Sci Eng

Exosomes Secreted by Stem Cells from Human Exfoliated Deciduous Teeth Promote Alveolar Bone Defect Repair through the Regulation of Angiogenesis and Osteogenesis. [Abstract]

2019 Jul 8;5(7):3561-3571. PMID: 33405738
Am J Chin Med

Arctii Fructus Inhibits Colorectal Cancer Cell Proliferation and MMPs Mediated Invasion via AMPK. [Abstract]

2017;45(6):1309-1325. PMID: 28830210

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Am J Chin Med. 2017;45(6):1309-1325. [Abstract]

Activity of MMP-2 and MMP-9 in water extract (WAF)- and ethanol extract (EtAF)-treated CT26 cells after CC (20 μM) pretreatment for 4 h.
Chem Biol Interact

Quercetin inhibits adipogenesis and promotes adipose tissue remodeling through lipophagy-mediated lipid droplet (LD) clearance. [Abstract]

2026 Jun 1:432:112053. PMID: 41864473
J Ethnopharmacol

Huaiqihuang granule attenuate renal injury in IgA vasculitis nephritis by activating AMPK/mTOR-mediated autophagy. [Abstract]

2026 Apr 6:360:121151. PMID: 41490554
J Ethnopharmacol

Shentong Zhuyu Decoction mitigates exercise-induced muscle damage through modulation of AMPK-mediated lipid metabolism and oxidative stress. [Abstract]

2026 Feb 28:357:120941. PMID: 41270908
Chem Biol Interact

Platycodin D reverses tumor necrosis factor-α-induced endothelial dysfunction by increasing nitric oxide through G protein-coupled estrogen receptor-mediated eNOS activity. [Abstract]

2025 May 28:111577. PMID: 40447174
Mar Drugs

Fucoxanthin from Laminaria japonica Targeting PANoptosis and Ferroptosis Pathways: Insights into Its Therapeutic Potential Against Ovarian Cancer. [Abstract]

2025 Mar 12;23(3):123. PMID: 40137309
World J Gastroenterol

Inhibition of metabotropic glutamate receptor-5 alleviates hepatic steatosis by enhancing autophagy via activation of the AMPK signaling pathway. [Abstract]

2025 Feb 21;31(7):98852. PMID: 39991675
J Ethnopharmacol

Drug pairs of Huangqi and Dnggui alleviates pyroptosis by promoting autophagy activity via AMPK/mTOR signaling pathway in middle-cerebral artery occlusion/reperfusion in rats. [Abstract]

2025 Jan 30;337(Pt 3):118982. PMID: 39454707
J Ethnopharmacol

Study on the role of Dihuang Yinzi in regulating the AMPK/SIRT1/PGC-1α pathway to promote mitochondrial biogenesis and improve Alzheimer's disease. [Abstract]

2025 Jan 30;337(Pt 2):118859. PMID: 39341266
J Ethnopharmacol

Yunnan baiyao exerts anti-glioma activity by inducing autophagy-dependent necroptosis. [Abstract]

2024 Aug 3:118658. PMID: 39103023
J Ethnopharmacol

Efficacy and mechanism of action of Yanxiao Di'naer formula for non-alcoholic steatohepatitis treatment based on metabolomics and RNA sequencing. [Abstract]

2024 Jun 24:333:118487. PMID: 38925322
Food Funct

Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense via the AMPK/SIRT3 signaling pathway. [Abstract]

2024 May 7;15(9):4954-4969. PMID: 38602356
Chem Biol Interact

Biochanin a ameliorates DSS-induced ulcerative colitis by improving colonic barrier function and protects against the development of spontaneous colitis in the Muc2 deficient mice. [Abstract]

2024 May 25:395:111014. PMID: 38648921
Chem Biol Interact

Trifluoperazine activates AMPK / mTOR / ULK1 signaling pathway to induce mitophagy in osteosarcoma cells. [Abstract]

2024 Apr 1:392:110904. PMID: 38360085
Food Funct

D-Mannose promotes recovery from experimental colitis by inducing AMPK phosphorylation to stimulate epithelial repair. [Abstract]

2024 Jan 22;15(2):625-646. PMID: 38099724
J Ethnopharmacol

Research into the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula based on network pharmacology, metabolomics, and verification of AMPK/PPAR-γ pathway of active ingredients. [Abstract]

2023 Dec 5:317:116773. PMID: 37308028
J Ethnopharmacol

Explorating the mechanism of Huangqin Tang against skin lipid accumulation through network pharmacology and experimental validation. [Abstract]

2023 Sep 15:313:116581. PMID: 37142143
J Ethnopharmacol

Aconitine induces autophagy via activating oxidative DNA damage-mediated AMPK/ULK1 signaling pathway in H9c2 cells. [Abstract]

2022 Jan 10:282:114631. PMID: 34520828
Food Funct

Puerarin improves hepatic glucose and lipid homeostasis in vitro and in vivo by regulating the AMPK pathway. [Abstract]

2021 Mar 21;12(6):2726-2740. PMID: 33681875
Food Funct

Activation of AMPK/Sirt3 pathway by phloretin reduces mitochondrial ROS in vascular endothelium by increasing the activity of MnSOD via deacetylation. [Abstract]

2020 Apr 1;11(4):3073-3083. PMID: 32195489
Food Funct

γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways. [Abstract]

2019 Oct 16;10(10):6858-6872. PMID: 31584590
Inflammopharmacology

Exogenous stromal cell-derived factor-1 (SDF-1) suppresses the NLRP3 inflammasome and inhibits pyroptosis in synoviocytes from osteoarthritic joints via activation of the AMPK signaling pathway. [Abstract]

2021 Jun;29(3):695-704. PMID: 34085175
J Am Heart Assoc

Metformin Improves Neurologic Outcome Via AMP-Activated Protein Kinase-Mediated Autophagy Activation in a Rat Model of Cardiac Arrest and Resuscitation. [Abstract]

2018 Jun 12;7(12). pii: e008389. PMID: 29895585

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Am Heart Assoc. 2018 Jun 12;7(12). pii: e008389. [Abstract]

Representative immunoblots of LC3 in Hippo and cortical brain tissue after CA/CPR. β-Actin serves as a loading control. J, Optical densities of LC3-II and LC3-I protein bands are quantitated. Cc indicates compound C.

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Am Heart Assoc. 2018 Jun 12;7(12). pii: e008389. [Abstract]

Representative photomicrographs of immunohistochemistry for MAP2, Nissl, Iba-1, and GFAP in the hippocampal CA1 region of the sham-operated, sham-treated with Met (Met-a), and the experimental groups (Veh, Mettreated group, compound C [Cc]–treated group, Met+Cc-treated group, CQ–treated group, and Met+CQ-treated group) at 7 days after return of spontaneous circulation.
Cells

Hepatic Polarized Differentiation Promoted the Maturity and Liver Function of Human Embryonic Stem Cell-Derived Hepatocytes via Activating Hippo and AMPK Signaling Pathways. [Abstract]

2022 Dec 18;11(24):4117. PMID: 36552880
Cells

Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens. [Abstract]

2022 Oct 18;11(20):3270. PMID: 36291137
Liver Int

Serine/threonine protein phosphatase 5 is a potential therapeutic target in cholangiocarcinoma. [Abstract]

2018 Dec;38(12):2248-2259. PMID: 29797403

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Liver Int. 2018 Dec;38(12):2248-2259. [Abstract]

Cells are treated with 5 μM Dorsomorphin dihydrochloride (Compound C) for 3 hours to inhibit AMPK activity. Next, 2.5 μM CTD is applied for 24 hours. Cells are then collected for apoptosis assays and western blotting.
Commun Biol

The fungistatic mechanism of benzaldehyde against the nematophagous fungus Arthrobotrys oligospora suggests a method for manipulating soil fungistasis. [Abstract]

2026 Mar 10;9(1):566. PMID: 41807727
Life Sci

Oxytocin ameliorates cardiac hypertrophy by inhibiting mitochondrial dysfunction and pyroptosis via AMPK/PGC-1α /TFAM pathway. [Abstract]

2026 Apr 15:391:124281. PMID: 41722768
Glia

RetSat Knockout Mitigates Hypoxia-Induced Microglial Activation by Enhancing Lipid Droplets Degradation. [Abstract]

2026 Feb;74(2):e70118. PMID: 41388745
Commun Biol

Biphasic protective effects of macrophage migration inhibitory factor in ischemia/reperfusion-induced acute kidney injury. [Abstract]

2025 Jul 28;8(1):1112. PMID: 40721484
Glia

Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing. [Abstract]

2025 Jul 24. PMID: 40708167
Commun Biol

Human placenta mesenchymal stromal cells alleviate intestinal inflammation and repair intestinal barrier function by activating AMPK-FXR pathway. [Abstract]

2025 May 30;8(1):830. PMID: 40447793
Commun Biol

Nanocrystalline cellulose-geniposide complex enhances gut-brain axis modulation for depression treatment. [Abstract]

2025 Apr 26;8(1):667. PMID: 40287572
Life Sci

Inhibitory effects of naringenin on estrogen deficiency-induced obesity via regulation of mitochondrial dynamics and AMPK activation associated with white adipose tissue browning. [Abstract]

2024 Mar 1:340:122453. PMID: 38272439
Drug Des Devel Ther

Si-Ni-San Reduces Hepatic Lipid Deposition in Rats with Metabolic Associated Fatty Liver Disease by AMPK/SIRT1 Pathway. [Abstract]

2023 Oct 3:17:3047-3060. PMID: 37808345
Life Sci

Bone marrow mesenchymal stem cells alleviate stress-induced hyperalgesia via restoring gut microbiota and inhibiting neuroinflammation in the spinal cord by targeting the AMPK/NF-κB signaling pathway. [Abstract]

2023 Feb 1:314:121318. PMID: 36566879
Commun Biol

Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival. [Abstract]

2022 Jun 22;5(1):616. PMID: 35732814
Drug Des Devel Ther

Berberine Influences the Survival of Fat Grafting by Inhibiting Autophagy and Apoptosis of Human Adipose Derived Mesenchymal Stem Cells. [Abstract]

2021 Nov 30;15:4795-4809. PMID: 34876804
Life Sci

Ligature induced periodontitis in rats causes gut dysbiosis leading to hepatic injury through SCD1/AMPK signalling pathway. [Abstract]

2022 Jan 1:288:120162. PMID: 34813797
Drug Des Devel Ther

Geniposide from Gardenia jasminoides var. radicans Makino Attenuates Myocardial Injury in Spontaneously Hypertensive Rats via Regulating Apoptotic and Energy Metabolism Signalling Pathway. [Abstract]

2021 Mar 3:15:949-962. PMID: 33688169
Life Sci

Compound K inhibits autophagy-mediated apoptosis induced by oxygen and glucose deprivation/reperfusion via regulating AMPK-mTOR pathway in neurons. [Abstract]

2020 Aug 1;254:117793. PMID: 32416164
Life Sci

Amentoflavone suppresses cell proliferation and induces cell death through triggering autophagy-dependent ferroptosis in human glioma. [Abstract]

2020 Apr 15;247:117425. PMID: 32057904
Life Sci

IL-17A-stimulated endothelial fatty acid β-oxidation promotes tumor angiogenesis. [Abstract]

2019 Jul 15:229:46-56. PMID: 31085243

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Life Sci. 2019 Jul 15:229:46-56. [Abstract]

Expression of APOE and COX5A in HUVECs treated with or without rhIL-17A (50 ng/mL) and Compound C (5 μM) is measured by western blot.
Life Sci

Cholinergic drugs ameliorate endothelial dysfunction by decreasing O-GlcNAcylation via M3 AChR-AMPK-ER stress signaling. [Abstract]

2019 Apr 1:222:1-12. PMID: 30786250
Nutrients

α-Lipoic Acid Alleviates Non-Alcoholic Fatty Liver Disease by Elevating Chaperone-Mediated Autophagy and Increasing β-Oxidation via AMPK-TFEB Axis. [Abstract]

2026 Jan 26;18(3):402. PMID: 41683226
Inflammation

Activation of β2-Adrenergic Receptor Alleviates Viral Myocarditis by Regulating Energy Metabolism in Monocyte-derived Macrophages via the AMPK Pathway. [Abstract]

2026 Jan 15;49(1):48. PMID: 41537900
Inflammation

Spermidine Alleviates Sepsis-Induced Acute Lung Injury through AMPK-Mediated Improvement of Necroptosis. [Abstract]

2025 Dec 19;49(1):9. PMID: 41417107
CNS Neurosci Ther

Metrnl/C-KIT Axis Attenuates Early Brain Injury Following Subarachnoid Hemorrhage by Inhibiting Neuronal Ferroptosis. [Abstract]

2025 Feb;31(2):e70286. PMID: 39981761
Respir Res

Ferritinophagy mediated by the AMPK/ULK1 pathway is involved in ferroptosis subsequent to ventilator-induced lung injury. [Abstract]

2024 Dec 24;25(1):440. PMID: 39719634
Inflammation

Metformin Attenuates Vocal Fold Fibrosis via AMPK Signaling. [Abstract]

2024 Oct 24. PMID: 39446178
Nutrients

1,25-Dihydroxyvitamin D3 Provides Benefits in Vitiligo Based on Modulation of CD8+ T Cell Glycolysis and Function. [Abstract]

2023 Nov 6;15(21):4697. PMID: 37960350
CNS Neurosci Ther

14, 15-EET alleviates neurological impairment through maintaining mitochondrial dynamics equilibrium via AMPK/SIRT1/FoxO1 signal pathways in mice with cerebral ischemia reperfusion. [Abstract]

2023 Sep;29(9):2583-2596. PMID: 37017405
Nutrients

11β-HSD1 Inhibitor Alleviates Non-Alcoholic Fatty Liver Disease by Activating the AMPK/SIRT1 Signaling Pathway. [Abstract]

2022 Jun 6;14(11):2358. PMID: 35684158
Nutrients

Distinct AMPK-Mediated FAS/HSL Pathway Is Implicated in the Alleviating Effect of Nuciferine on Obesity and Hepatic Steatosis in HFD-Fed Mice. [Abstract]

2022 Apr 30;14(9):1898. PMID: 35565866
Nutrients

Betulin Inhibits Lung Metastasis by Inducing Cell Cycle Arrest, Autophagy, and Apoptosis of Metastatic Colorectal Cancer Cells. [Abstract]

2019 Dec 26;12(1):66. PMID: 31887988
J Nutr Biochem

Ketogenic diet modulates AMPK-mTOR pathway in breast cancer. [Abstract]

2026 Jul:153:110312. PMID: 41688032
J Affect Disord

Ketamine ameliorates postpartum depression-like behaviors in rats exposed to sevoflurane during pregnancy through the AMPK/SIRT1/NLRP3 pathway. [Abstract]

2026 Jun 15:403:121439. PMID: 41698615
J Nutr Biochem

Coenzyme Q10 ameliorates obesity by promoting white adipose tissue browning and preserving mitochondrial dynamics in ovariectomized rats fed a high-fat diet. [Abstract]

2025 Nov 22:149:110187. PMID: 41275978
J Nutr Biochem

Network pharmacology and transcriptomics reveal complanatoside A regulates lipid metabolism in hyperlipidemia and nonalcoholic fatty liver disease via the AMPK pathway. [Abstract]

2025 May 10:109960. PMID: 40354830
Int J Mol Sci

Stress-Induced Cholesterol Metabolic Dysregulation and Differentiation Trajectory Shift in Oligodendrocytes Synergistically Drive Demyelination. [Abstract]

2025 Apr 9;26(8):3517. PMID: 40332029
J Nutr Biochem

Medium-chain triglyceride attenuates obesity by activating brown adipose tissue via upregulating the AMPK signaling pathway. [Abstract]

2025 Apr 1:109914. PMID: 40179992
Int J Mol Sci

Methylmercury Chloride Exposure Affects Oocyte Maturation Through AMPK/mTOR-Mediated Mitochondrial Autophagy. [Abstract]

2025 Apr 11;26(8):3603. PMID: 40332119
J Nutr Biochem

Luteolin alleviates muscle atrophy, mitochondrial dysfunction and abnormal FNDC5 expression in high fat diet-induced obese rats and palmitic acid-treated C2C12 myotubes. [Abstract]

2025 Jan:135:109780. PMID: 39395694
Biol Direct

Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway. [Abstract]

2024 Aug 2;19(1):62. PMID: 39095871
Int J Mol Sci

O-GlcNAc Modification Is a Promising Therapeutic Target for Diabetic Retinopathy. [Abstract]

2024 Jun 6;25(11):6286. PMID: 38892474
Int J Mol Sci

Pin1 Exacerbates Non-Alcoholic Fatty Liver Disease by Enhancing Its Activity through Binding to ACC1. [Abstract]

2024 May 27;25(11):5822. PMID: 38892011
J Nutr Biochem

Calorie restriction mimetic, resveratrol, attenuates hepatic ischemia and reperfusion injury through enhancing efferocytosis of macrophages via AMPK/STAT3/S1PR1 pathway. [Abstract]

2024 Apr:126:109587. PMID: 38262562
Int J Mol Sci

Metformin Attenuates TGF-β1-Induced Fibrosis in Salivary Gland: A Preliminary Study. [Abstract]

2023 Nov 13;24(22):16260. PMID: 38003450
Int J Mol Sci

JAC4 Inhibits EGFR-Driven Lung Adenocarcinoma Growth and Metastasis through CTBP1-Mediated JWA/AMPK/NEDD4L/EGFR Axis. [Abstract]

2023 May 15;24(10):8794. PMID: 37240137
Int J Mol Sci

Quercetin Reprograms Immunometabolism of Macrophages via the SIRT1/PGC-1α Signaling Pathway to Ameliorate Lipopolysaccharide-Induced Oxidative Damage. [Abstract]

2023 Mar 14;24(6):5542. PMID: 36982615
Int J Mol Sci

Deficiency of S100A9 Alleviates Sepsis-Induced Acute Liver Injury through Regulating AKT-AMPK-Dependent Mitochondrial Energy Metabolism. [Abstract]

2023 Jan 20;24(3):2112. PMID: 36768433
Int J Mol Sci

Salicylate Sodium Suppresses Monocyte Chemoattractant Protein-1 Production by Directly Inhibiting Phosphodiesterase 3B in TNF-α-Stimulated Adipocytes. [Abstract]

2022 Dec 24;24(1):320. PMID: 36613764
Int J Mol Sci

Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK. [Abstract]

2017 May 19;18(5). pii: E1063. PMID: 28534819

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2017 May 19;18(5). pii: E1063. [Abstract]

Inhibition of sirt1 and AMPK blocked Rb2-induced hepatic autophagy. HepG2 cells are pretreated with 50 µM Rb2 for 4 h in the presence or absence of the sirt1 inhibitor EX-528 (EX) and the specific AMPK inhibitor Compound C (CC), and then subjected to OA (1 mM for HepG2 and 2 mM for primary mouse hepatocytes) exposure for 12 h. For lipid content determination, intracellular TG are stained by Oil red O (ORO). ORO is then eluted with isopropanol and the optical absorbance of the eluate is measured
Biomolecules

2026 Apr;16(4):506.
Front Pharmacol

Metformin attenuates diabetic osteoporosis by suppressing ferroptosis via the AMPK/Nrf2 pathway. [Abstract]

2025 Mar 26:16:1527316. PMID: 40206070
Front Pharmacol

The novel TFEB agonist desloratadine ameliorates hepatic steatosis by activating the autophagy-lysosome pathway. [Abstract]

2024 Sep 18:15:1449178. PMID: 39359254
Front Pharmacol

Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond. [Abstract]

2024 Oct 23:15:1496639. PMID: 39508046
Matrix Biol

Collagen VI ablation in zebrafish causes neuromuscular defects during developmental and adult stages. [Abstract]

2022 Sep:112:39-61. PMID: 35961424
Front Pharmacol

Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1. [Abstract]

2022 May 16;13:848957. PMID: 35652039
Front Pharmacol

Metformin Ameliorates Chronic Colitis-Related Intestinal Fibrosis via Inhibiting TGF-β1/Smad3 Signaling. [Abstract]

2022 May 13;13:887497. PMID: 35645830
Front Pharmacol

Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control. [Abstract]

2022 Mar 8;13:824138. PMID: 35350766
Front Pharmacol

Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway. [Abstract]

2021 Jul 7:12:687394. PMID: 34305600
Front Pharmacol

Caveolin-1 Alleviates Acetaminophen-Induced Fat Accumulation in Non-Alcoholic Fatty Liver Disease by Enhancing Hepatic Antioxidant Ability via Activating AMPK Pathway. [Abstract]

2021 Jul 7:12:717276. PMID: 34305621
Front Pharmacol

Jujuboside B Inhibits Neointimal Hyperplasia and Prevents Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and Migration via Activation of AMPK/PPAR-γ Signaling. [Abstract]

2021 Jun 24:12:672150. PMID: 34248626
Front Pharmacol

Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway. [Abstract]

2021 Apr 29:12:667524. PMID: 33995096
Front Pharmacol

Exogenous Hydrogen Sulfide Ameliorates Diabetic Myocardial Fibrosis by Inhibiting Cell Aging Through SIRT6/AMPK Autophagy. [Abstract]

2020 Jul 31;11:1150. PMID: 32903815
Front Pharmacol

Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1. [Abstract]

2020 Jul 29;11:1136. PMID: 32848753
Front Pharmacol

Eugenol Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Autophagy via AMPK-mTOR-P70S6K Pathway. [Abstract]

2020 Feb 21;11:84. PMID: 32153404
Front Pharmacol

Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells. [Abstract]

2018 Aug 29:9:986. PMID: 30210348

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Aug 29:9:986. [Abstract]

AMPK and p38 phosphorylation is confirmed after Compound C (CC) and SB203580 treatment of Gomisin A (G.A)-treated CT26 cells.
Front Pharmacol

Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin. [Abstract]

2018 Jul 16:9:761. PMID: 30061832

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Jul 16:9:761. [Abstract]

Epithelial cells from colon tissue are extracted from mice in each group (n=6-8 per group) and protein level of p-AMPK (Thr172) and AMPKα1/2 are measured by western blot.
Front Pharmacol

Rosmarinic Acid Activates AMPK to Inhibit Metastasis of Colorectal Cancer. [Abstract]

2018 Feb 5:9:68. PMID: 29459827

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Feb 5:9:68. [Abstract]

CT26 cells are treated with CC for 4 h and detected phosphorylation levels of AMPK.
Int Immunopharmacol

Baicalein limits subchondral bone lesions via AMPKα/BECN1 activation in osteoarthritis osteoblast. [Abstract]

2026 Apr 15:175:116446. PMID: 41791307
Int Immunopharmacol

An indoloquinolinone 3a alleviates lipopolysaccharide-induced acute lung injury by modulating the NF-κB and AMPK/Nrf2 signaling pathways. [Abstract]

2026 Apr 1:174:116398. PMID: 41698296
Int Immunopharmacol

Paeoniflorin suppresses cardiomyocyte pyroptosis and ameliorates diabetic cardiomyopathy by AMPK/Nrf2/NLRP3 pathway. [Abstract]

2025 Dec 31:171:116122. PMID: 41477992
Int Immunopharmacol

GLP-1 receptor agonist liraglutide facilitates rotator cuff healing by reducing tendon cell inflammation and endoplasmic reticulum stress through the GLP-1R-AMPK/SIRT1 pathway. [Abstract]

2025 Dec 11:169:116010. PMID: 41386184
Eur J Pharmacol

Cordycepin deteriorates 5' fluorouracil-induced anaemia by AMPK activation. [Abstract]

2025 Oct 11:1007:178232. PMID: 41082995
Bioorg Chem

Lujiao Formula attenuates cardiac hypertrophy by modulating AMPK-SIRT1 and PI3K-Akt signaling pathways. [Abstract]

2025 Sep 25:165:109001. PMID: 41045706
Int Immunopharmacol

ABCA4 regulates mitophagy in lung adenocarcinoma progression via AMPK pathway by modulating TMSB4X. [Abstract]

2025 Aug 2:163:115305. PMID: 40753852
Am J Physiol Cell Physiol

Uncoupling protein 3 (UCP3) regulates energy and stress related pathways in undifferentiated skeletal muscle myoblasts. [Abstract]

2025 Aug 25. PMID: 40853893
Int Immunopharmacol

Metformin mitigates inflammation and apoptosis in salivary gland epithelial cells via an AMPK-dependent mechanism in chronic obstructive sialadenitis. [Abstract]

2025 Aug 10:164:115345. PMID: 40789239
Eur J Pharmacol

Hesperidin attenuates lipopolysaccharide-induced endometritis by inhibiting mitochondrial oxidative stress via activating the AMPK/PGC-1α signalling pathway. [Abstract]

2025 Aug 29:1005:178100. PMID: 40886876
Int Immunopharmacol

Vitamin E exerts a mitigating effect on LPS-induced acute lung injury by regulating macrophage polarization through the AMPK/NRF2/NF-κB pathway. [Abstract]

2025 May 21:159:114893. PMID: 40403505
Int Immunopharmacol

Ginsenoside Rh1 attenuates chondrocyte senescence and osteoarthritis via AMPK/PINK1/Parkin-mediated mitophagy. [Abstract]

2025 May 22:159:114911. PMID: 40409109
Int Immunopharmacol

Betulinic acid enhances autopahgy to promote microglial M2 polarization and alleviate inflammation via AMPK-HDAC5-KLF2 signaling pathways in spinal cord injury. [Abstract]

2025 May 18:158:114889. PMID: 40388862
Int Immunopharmacol

Icariin alleviates cardiomyocyte pyroptosis through AMPK-NLRP3 pathway to ameliorates diabetic cardiomyopathy. [Abstract]

2025 Apr 21:156:114690. PMID: 40262250
Eur J Pharmacol

Rutin protects the pancreas from inflammatory injury and oncogene-driven tumorigenesis by inhibiting acinar to ductal metaplasia. [Abstract]

2025 Jul 5:998:177536. PMID: 40120793
Eur J Pharmacol

Steroid constituents of Solidago canadensis alleviate LPS-induced inflammation via AMPK regulated mitophagy/NLRP3 and NF-κB pathway. [Abstract]

2025 Mar 18:177512. PMID: 40113066
Eur J Pharmacol

VDAC1-NF-κB/p65-mediated S100A16 contributes to myocardial ischemia/reperfusion injury by regulating oxidative stress and inflammatory response via calmodulin/CaMKK2/AMPK pathway. [Abstract]

2024 Nov 27:177158. PMID: 39613175
mBio

The vitamin D receptor is essential for the replication of pseudorabies virus. [Abstract]

2024 Oct 30:e0213724. PMID: 39475231
Int Immunopharmacol

Palmitic acid inhibits macrophage-mediated chemotherapy resistance in multiple myeloma via ALOX12 signaling. [Abstract]

2024 Oct 7;143(Pt 1):113320. PMID: 39378653
Int Immunopharmacol

NDUFS3 alleviates oxidative stress and ferroptosis in sepsis induced acute kidney injury through AMPK pathway. [Abstract]

2024 Oct 18;143(Pt 2):113393. PMID: 39426231
Cell Regen

Endogenous retroviral ERVH48-1 promotes human urine cell reprogramming. [Abstract]

2024 Sep 13;13(1):17. PMID: 39269631
Int Immunopharmacol

Nobiletin alleviates macrophage M2 polarization by activating AMPK-mTOR-mediated autophagy in pulmonary fibrosis mice. [Abstract]

2024 Jul 28:139:112792. PMID: 39079195
Int Immunopharmacol

Network pharmacology and experimental verification revealing valnemulin alleviates DSS-induced ulcerative colitis by inhibiting intestinal senescence. [Abstract]

2024 Aug 15:141:112810. PMID: 39151382
Int Immunopharmacol

Irisin attenuates acute glaucoma-induced neuroinflammation by activating microglia-integrin αVβ5/AMPK and promoting autophagy. [Abstract]

2024 Jul 1:138:112545. PMID: 38955026
Eur J Pharmacol

Cytarabine prevents neuronal damage by enhancing AMPK to stimulate PINK1 / Parkin-involved mitophagy in Parkinson's disease model. [Abstract]

2024 Jun 14:176743. PMID: 38880222
Eur J Pharmacol

Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps. [Abstract]

2024 Jul 5:974:176621. PMID: 38679118
Int Immunopharmacol

Cordycepin alleviates hepatic fibrosis in association with the inhibition of glutaminolysis to promote hepatic stellate cell senescence. [Abstract]

2024 May 10:132:111981. PMID: 38565039
mBio

The glycoprotein 5 of porcine reproductive and respiratory syndrome virus stimulates mitochondrial ROS to facilitate viral replication. [Abstract]

2023 Dec 19;14(6):e0265123. PMID: 38047681
Eur J Pharmacol

Catalpol ameliorates LPS-induced inflammatory response by activating AMPK/mTOR signaling pathway in rat intestinal epithelial cells. [Abstract]

2023 Dec 5:960:176125. PMID: 37890606
Eur J Pharmacol

Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer. [Abstract]

2023 Oct 15:957:176035. PMID: 37657741
Int Immunopharmacol

Melatonin exerts a protective effect in ameliorating nephrolithiasis via targeting AMPK/PINK1-Parkin mediated mitophagy and inhibiting ferroptosis in vivo and in vitro. [Abstract]

2023 Aug 29;124(Pt A):110801. PMID: 37651854
Eur J Pharmacol

Alisol B blocks the development of HFD-induced obesity by triggering the LKB1-AMPK signaling in subcutaneous adipose tissue. [Abstract]

2023 Oct 5:956:175942. PMID: 37536624
Int Immunopharmacol

Limonin, a novel AMPK activator, protects against LPS-induced acute lung injury. [Abstract]

2023 Sep:122:110678. PMID: 37481848
Int Immunopharmacol

Forsythoside A regulates autophagy and apoptosis through the AMPK/mTOR/ULK1 pathway and alleviates inflammatory damage in MAC-T cells. [Abstract]

2023 May:118:110053. PMID: 36965368
Int Immunopharmacol

Nuciferine improves random skin flap survival via TFEB-mediated activation of autophagy-lysosomal pathway. [Abstract]

2023 Jun:119:110204. PMID: 37126988
Int Immunopharmacol

Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway. [Abstract]

2023 Jun:119:110192. PMID: 37068341
Int Immunopharmacol

Anti-Na+/K+-ATPase DR antibody attenuates UUO-induced renal fibrosis through inhibition of Na+/K+-ATPase α1-dependent HMGB1 release. [Abstract]

2023 Mar:116:109826. PMID: 36764269
Int Immunopharmacol

Ferroptosis is involved in PM2.5-induced acute nasal epithelial injury via AMPK-mediated autophagy. [Abstract]

2023 Feb:115:109658. PMID: 36608444
Int Immunopharmacol

Phthalide derivative CD21 regulates the platelet- neutrophil extracellular trap-thrombin axis and protects against ischemic brain injury in rodents. [Abstract]

2023 Jan:114:109547. PMID: 36527877
Eur J Pharmacol

Nicorandil protects against coronary microembolization-induced myocardial injury by suppressing cardiomyocyte pyroptosis via the AMPK/TXNIP/NLRP3 signaling pathway. [Abstract]

2022 Dec 5:936:175365. PMID: 36336011
Int Immunopharmacol

Acadesine alleviates acute pancreatitis-related lung injury by mediating the barrier protective function of pulmonary microvascular endothelial cells. [Abstract]

2022 Oct:111:109165. PMID: 35987144
Int Immunopharmacol

Gitogenin suppresses lung cancer progression by inducing apoptosis and autophagy initiation through the activation of AMPK signaling. [Abstract]

2022 Oct:111:108806. PMID: 35914447
Int Immunopharmacol

Activation of the AMPK-ULK1 pathway mediated protective autophagy by sevoflurane anesthesia restrains LPS-induced acute lung injury (ALI). [Abstract]

2022 Jul:108:108869. PMID: 35605434
Int Immunopharmacol

SIRT3-AMPK signaling pathway as a protective target in endothelial dysfunction of early sepsis. [Abstract]

2022 May:106:108600. PMID: 35217431
Eur J Pharmacol

Dapagliflozin attenuates steatosis in livers of high-fat diet-induced mice and oleic acid-treated L02 cells via regulating AMPK/mTOR pathway. [Abstract]

2021 Sep 15:907:174304. PMID: 34224699
Int Immunopharmacol

Dopamine D1 receptor agonist A-68930 ameliorates Aβ1-42-induced cognitive impairment and neuroinflammation in mice. [Abstract]

2020 Nov;88:106963. PMID: 33182028
Zool Res

Metformin improves boar sperm quality via 5'-AMP-activated protein kinase-mediated energy metabolism in vitro. [Abstract]

2020 Sep 18;41(5):527-538. PMID: 32738111
Int Immunopharmacol

Protectin DX attenuates IL-1β-induced inflammation via the AMPK/NF-κB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model. [Abstract]

2020 Jan;78:106043. PMID: 31837574
Eur J Pharmacol

Berberine inhibits low shear stress-induced glycocalyx degradation via modulating AMPK and p47phox/Hyal2 signal pathway. [Abstract]

2019 Aug 5;856:172413. PMID: 31152700
Molecules

α-Linolenic Acid Alleviates Diabetic Cardiomyopathy by Activating AMPK-STAT3 Pathway to Inhibit Ferritinophagy and Enhance SLC7A11-GPX4 Antioxidant Axis. [Abstract]

2025 Dec 24;31(1):79. PMID: 41515376
World J Diabetes

Liraglutide alleviates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by enhancing mitophagy mediated by the AMPK-Parkin signaling pathway. [Abstract]

2025 Dec 15;16(12):112423. PMID: 41480600
Neuropharmacology

ACVR1 drives neuropathic pain by regulating NLRP3-Induced neuronal pyroptosis through the p38 and Smad1/5/8 pathways. [Abstract]

2025 Apr 16:110469. PMID: 40250754
Neuropharmacology

SARM1 deficiency induced depressive-like behavior via AMPKα/p-eEF2 axis to synapse dysfunction. [Abstract]

2024 Nov 1:110206. PMID: 39489288
Neuropharmacology

Sodium butyrate improves cognitive dysfunction in high-fat diet/ streptozotocin-induced type 2 diabetic mice by ameliorating hippocampal mitochondrial damage through regulating AMPK/PGC-1α pathway. [Abstract]

2024 Sep 2:110139. PMID: 39233201
Molecules

Tiliroside Attenuates NLRP3 Inflammasome Activation in Macrophages and Protects against Acute Lung Injury in Mice. [Abstract]

2023 Nov 10;28(22):7527. PMID: 38005247
Molecules

Protective Effect of Ferulic Acid on Lipopolysaccharide-Induced BV2 Microglia Inflammation via AMPK/mTOR Signaling Pathway. [Abstract]

2023 Apr 14;28(8):3482. PMID: 37110714
Biol Res

Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress. [Abstract]

2020 Oct 27;53(1):50. PMID: 33109277
Front Microbiol

Porcine Circovirus Type 2 ORF5 Protein Induces Autophagy to Promote Viral Replication via the PERK-eIF2α-ATF4 and mTOR-ERK1/2-AMPK Signaling Pathways in PK-15 Cells. [Abstract]

2020 Feb 28;11:320. PMID: 32184774
Mol Oncol

Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6-independent manner. [Abstract]

2017 Aug;11(8):1035-1049. PMID: 28453226

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Mol Oncol. 2017 Aug;11(8):1035-1049. [Abstract]

Inhibition of AMPK reverses PD 0332991-induced autophagy and apoptosis. Hep3B cells are incubated with AMPK inhibitor (Compound C, 2.5 μM) for 4 h and then treated with PD 0332991 for 24 h. Apoptotic cells are determined by flow cytometry.
Biomed J

PRMT5-mediated methylation of LKB1 controls PD-L1 expression in NSCLC. [Abstract]

2026 Jun 10:101002. PMID: 42270077
J Dairy Sci

Bovine lactoferrin improves doxorubicin- and ischemia-reperfusion-induced myocardial injury by activating AMPK-mediated signaling pathways. [Abstract]

2026 Feb 10:S0022-0302(26)00100-1. PMID: 41679643
J Dairy Sci

Salidroside protects bovine hepatocytes against fatty acid-induced lipid accumulation and inflammation by activating AMPK/SIRT1 pathway. [Abstract]

2025 Sep;108(9):10136-10150. PMID: 40645487
J Dairy Sci

Sirtuin 3 mitigates oxidative-stress-induced apoptosis in bovine mammary epithelial cells. [Abstract]

2023 Oct;106(10):7266-7280. PMID: 37730176
J Dairy Sci

AMPK-endoplasmic reticulum stress axis contributes to lipopolysaccharide-caused mitochondrial dysfunction by regulating mitochondria-associated membrane function in bovine hepatocytes. [Abstract]

2023 Jul;106(7):5146-5164. PMID: 37225589
Cancers (Basel)

High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway. [Abstract]

2023 Apr 23;15(9):2427. PMID: 37173894
Lung Cancer

Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation. [Abstract]

2017 Oct:112:81-89. PMID: 29191605
Mol Neurobiol

Aerobic Exercise Activates Fibroblast Growth Factor 21 and Alleviates Cardiac Ischemia/Reperfusion-induced Neuronal Oxidative Stress and Ferroptosis in Paraventricular Nucleus. [Abstract]

2025 Jul;62(7):8484-8501. PMID: 40009261
Poult Sci

The adiponectin receptor agonist AdipoRon alleviates lipotoxic injury in LMH cells. [Abstract]

2026 Feb 1;105(4):106573. PMID: 41650643
J Clin Transl Hepatol

2025.
J Cell Mol Med

Dexamethasone Promotes Autophagy Dependent Ferroptosis of Placental Trophoblast Cells Through GRα. [Abstract]

2025 Jul;29(13):e70613. PMID: 40624893
FASEB J

A Novel Role of Adipokine 'Intelectin-1': Ameliorating Renal Fibrosis Through Inhibition of Renal Tubular Epithelial Cell Senescence. [Abstract]

2025 May 31;39(10):e70653. PMID: 40387543
Biochim Biophys Acta Mol Basis Dis

METTL3 promotes human amniotic epithelial stem cells differentiation into insulin-producing cells by regulation of MaFA expression. [Abstract]

2025 May 13:167904. PMID: 40374016
J Cell Mol Med

Danuglipron Ameliorates Pressure Overload-Induced Cardiac Remodelling Through the AMPK Pathway. [Abstract]

2025 Mar;29(5):e70488. PMID: 40070049
Poult Sci

Fowl adenovirus serotype-4 induces autophagy via the AMPK-mTOR signaling pathway during viral invasion of host cells. [Abstract]

2025 Apr;104(4):104967. PMID: 40106851
Biochim Biophys Acta Mol Basis Dis

IFN-γ-responsiveness of lymphatic endothelial cells inhibits melanoma lymphatic dissemination via AMPK-mediated metabolic control. [Abstract]

2024 Jun 25:167314. PMID: 38936516
Biochim Biophys Acta Mol Basis Dis

Cyanidin-3-O-glucoside alleviates ethanol-induced liver injury by promoting mitophagy in a Gao-binge mouse model of alcohol-associated liver disease. [Abstract]

2024 May 25;1870(6):167259. PMID: 38796918
FASEB J

Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia. [Abstract]

2024 May 31;38(10):e23671. PMID: 38752538
Mol Nutr Food Res

Pretreatment with Kahweol Attenuates Sepsis-Induced Acute Lung Injury via Improving Mitochondrial Homeostasis in a CaMKKII/AMPK-Dependent Pathway. [Abstract]

2023 Oct;67(19):e2300083. PMID: 37483173
Exp Neurol

Exercise pretreatment alleviates neuroinflammation and oxidative stress by TFEB-mediated autophagic flux in mice with ischemic stroke. [Abstract]

2023 Jun:364:114380. PMID: 36914085
J Cell Mol Med

NR3C2 inhibits the proliferation of colorectal cancer via regulating glucose metabolism and phosphorylating AMPK. [Abstract]

2023 Apr;27(8):1069-1082. PMID: 36950803
J Food Biochem

Biochanin A ameliorated oleate-induced steatosis in HepG2 cells by activating the SIRT3/AMPK/ULK-1 signaling pathway. [Abstract]

2022 Sep 20;e14428. PMID: 36125796
J Cell Mol Med

Resveratrol, novel application by preconditioning to attenuate myocardial ischemia/reperfusion injury in mice through regulate AMPK pathway and autophagy level. [Abstract]

2022 Aug;26(15):4216-4229. PMID: 35791579
Bioengineered

Calcium-binding protein 39 overexpression promotes macrophages from 'M1' into 'M2' phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axis. [Abstract]

2022 Apr;13(4):9855-9871. PMID: 35412939
Biochim Biophys Acta Mol Basis Dis

Myeloid differential protein-2 inhibition improves diabetic cardiomyopathy via p38MAPK inhibition and AMPK pathway activation. [Abstract]

2022 May 1;1868(5):166369. PMID: 35176461
J Cell Mol Med

Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy. [Abstract]

2022 Feb;26(3):893-912. PMID: 34964241
J Cell Mol Med

Dihydromyricetin resists inflammation-induced muscle atrophy via ryanodine receptor-CaMKK-AMPK signal pathway. [Abstract]

2021 Nov;25(21):9953-9971. PMID: 34676967
Mediators Inflamm

Anti-Inflammatory Effect of Curcumin on the Mouse Model of Myocardial Infarction through Regulating Macrophage Polarization. [Abstract]

2021 Aug 21:2021:9976912. PMID: 34462629
J Cell Mol Med

Gastrodin induces lysosomal biogenesis and autophagy to prevent the formation of foam cells via AMPK-FoxO1-TFEB signalling axis. [Abstract]

2021 Jun;25(12):5769-5781. PMID: 33973365
J Cell Mol Med

FGF19 protects skeletal muscle against obesity-induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT-1/PGC-α pathway. [Abstract]

2021 Apr;25(7):3585-3600. PMID: 33751819
Drug Develop Res

Ginsenoside Rg3 attenuates ovariectomy-induced osteoporosis via AMPK/mTOR signaling pathway. [Abstract]

2020 Nov;81(7):875-884. PMID: 32898934
J Cell Mol Med

Exosomes derived from umbilical cord mesenchymal stem cells alleviate viral myocarditis through activating AMPK/mTOR-mediated autophagy flux pathway. [Abstract]

2020 Jul;24(13):7515-7530. PMID: 32424968
J Cell Mol Med

Tamoxifen inhibits cell proliferation by impaired glucose metabolism in gallbladder cancer. [Abstract]

2020 Jan;24(2):1599-1613. PMID: 31782270
J Food Biochem

Vanillic acid alleviates palmitic acid-induced oxidative stress in human umbilical vein endothelial cells via Adenosine Monophosphate-Activated Protein Kinase signaling pathway. [Abstract]

2019 Jul;43(7):e12893. PMID: 31353730
J Cell Mol Med

Sodium (±)-5-bromo-2-(α-hydroxypentyl) benzoate ameliorates pressure overload-induced cardiac hypertrophy and dysfunction through inhibiting autophagy. [Abstract]

2019 Sep;23(9):6048-6059. PMID: 31222939
J Lipid Res

Aerobic glycolysis drives differentiation of unilocular adipocytes. [Abstract]

2026 Mar 16:101023. PMID: 41850682
iScience

Overfit deep neural network for predicting drug-target interactions. [Abstract]

2023 Aug 15;26(9):107646. PMID: 37680476
iScience

Amphibian pore-forming protein βγ-CAT drives extracellular nutrient scavenging under cell nutrient deficiency. [Abstract]

2023 Apr 7;26(5):106598. PMID: 37128610
Toxicol Sci

2,3,7,8-Tetrachlorodibenzo-dioxin induces liver lipid metabolism disorder via the ROS/AMPK/CD36 signaling pathway. [Abstract]

2023 Feb 17;191(2):276-284. PMID: 36534932
iScience

BxPC-3-Derived Small Extracellular Vesicles Induce FOXP3+ Treg through ATM-AMPK-Sirtuins-Mediated FOXOs Nuclear Translocations. [Abstract]

2020 Aug 21;23(8):101431. PMID: 32798974
Biomed Environ Sci

The Role of the AMPK Pathway in ZEA-induced Cellcycle Arrest in Rat Sertoli Cells. [Abstract]

2019 Dec;32(12):944-948. PMID: 31918802
Antiviral Res

Metformin inhibits EV-A71 and CVA16 infections by regulating TRIB3-SCARB2 axis and activating AMPK. [Abstract]

2025 Jan 16:235:106081. PMID: 39826812
J Funct Foods

2024 May, 116, 106168.
J Funct Foods

2024 Apr, 115, 106087.
J Funct Foods

2023 Dec, 111, 105902.
J Funct Foods

2023 Apr.
J Funct Foods

2022, 99: 105358.
J Integr Med

Qili Qiangxin, a compound herbal medicine formula, alleviates hypoxia-reoxygenation-induced apoptotic and autophagic cell death via suppression of ROS/AMPK/mTOR pathway in vitro. [Abstract]

2022 Jul;20(4):365-375. PMID: 35534381
J Funct Foods

January 2022, 104901.
J Funct Foods

December 2021, 104807.
J Dermatol Sci

Resveratrol ameliorates lipid accumulation and inflammation in human SZ95 sebocytes via the AMPK signaling pathways in vitro. [Abstract]

2021 Sep;103(3):156-166. PMID: 34334258
J Funct Foods

2021, 104556.
Front Cell Neurosci

Inhibition of Brd4 by JQ1 Promotes Functional Recovery From Spinal Cord Injury by Activating Autophagy. [Abstract]

2020 Sep 2;14:555591. PMID: 32982695
J Cell Physiol

C1q/TNF-related protein-9 promotes macrophage polarization and improves cardiac dysfunction after myocardial infarction. [Abstract]

2019 Aug;234(10):18731-18747. PMID: 30953351
J Funct Foods

s 59 (2019) 8-15.
J Cell Physiol

Hyaluronidase2 (Hyal2) modulates low shear stress-induced glycocalyx impairment via the LKB1/AMPK/NADPH oxidase-dependent pathway. [Abstract]

2018 Dec;233(12):9701-9715. PMID: 30078213

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2018 Dec;233(12):9701-9715. [Abstract]

HUVECs are pretreated with Compound C (5, 10, or 20 μM) for 18 hr or AICAR (1, 2, or 4 mM) for 1 hr, and then exposed to LSS for 30 min.
J Cell Physiol

The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration. [Abstract]

2018 May;233(5):3945-3954. PMID: 28884830

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2018 May;233(5):3945-3954. [Abstract]

Fraxinellone-prompted phosphorylation of AMPK is blocked by Compound C (CC).
Toxins

ROS-Mediated Cell Cycle Arrest and Apoptosis Induced by Zearalenone in Mouse Sertoli Cells via ER Stress and the ATP/AMPK Pathway. [Abstract]

2018 Jan 1;10(1). pii: E24. PMID: 29301253
Sci Rep

Metformin enhances TRAIL-mediated antitumor activity of liver natural killer cells in mice. [Abstract]

2026 Apr 20;16(1):18261. PMID: 42010272
J Cell Commun Signal

Phosphoenolpyruvate carboxykinase 2 activation of the AMPK-CEBPB axis to enhance glutamine utilization to promote glycolysis and malignant behavior in adenocarcinomas cells under glucose deprivation. [Abstract]

2026 Feb 27;20(1):e70064. PMID: 41769368
Sci Rep

Ionizing radiation triggers the release of mitochondrial DNA into the cytosol as a signal of mitochondrial damage. [Abstract]

2025 Jul 2;15(1):23191. PMID: 40603988
Sci Rep

Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling. [Abstract]

2025 Feb 19;15(1):6081. PMID: 39971923
J Biol Chem

Resveratrol reduces RVLM neuron activity via activating the AMPK/Sirt3 pathway in stress-induced hypertension. [Abstract]

2025 Apr;301(4):108394. PMID: 40074082
Aquaculture

2024 Dec 15.
ACS Chem Neurosci

Mitochondrial-Derived Peptide MOTS-c Ameliorates Spared Nerve Injury-Induced Neuropathic Pain in Mice by Inhibiting Microglia Activation and Neuronal Oxidative Damage in the Spinal Cord via the AMPK Pathway. [Abstract]

2023 Jun 21;14(12):2362-2374. PMID: 37285113
J Biol Chem

Glucose-6-phosphate dehydrogenase exerts anti-stress effects independently of its enzymatic activity. [Abstract]

2022 Dec;298(12):102587. PMID: 36243112
Neurotoxicology

Maf1 mitigates sevoflurane-induced microglial inflammatory damage and attenuates microglia-mediated neurotoxicity in HT-22 cells by activating the AMPK/Nrf2 signaling. [Abstract]

2022 May;90:237-245. PMID: 35430185
Fish Shellfish Immunol

Polysaccharide extract from pomelo fruitlet ameliorates diet-induced nonalcoholic fatty liver disease in hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀). [Abstract]

2021 Dec:119:114-127. PMID: 34607007
Aging (Albany NY)

Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome. [Abstract]

2021 Oct 9;13(19):23193-23209. PMID: 34628369
Aging

Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway. [Abstract]

2020 Nov 29;12(23):24318-24332. PMID: 33260158
Oncol Rep

VSP‑17 suppresses the migration and invasion of triple‑negative breast cancer cells through inhibition of the EMT process via the PPARγ/AMPK signaling pathway. [Abstract]

2021 Mar;45(3):975-986. PMID: 33650675
Oncol Rep

TRPC5‑induced autophagy promotes the TMZ‑resistance of glioma cells via the CAMMKβ/AMPKα/mTOR pathway. [Abstract]

2019 Jun;41(6):3413-3423. PMID: 30942446
J Biol Chem

The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake. [Abstract]

2019 Jul 5;294(27):10415-10427. PMID: 31113861
Neurochem Res

Propofol Modulates Microglial Glucose Metabolism Via the AMPK/HIF-1α Signaling Pathway To Ameliorate ECS-induced Cognitive Deficits in Depressive-like Rats. [Abstract]

2025 Jun 30;50(4):219. PMID: 40587030
Microbiol Spectr

The TgAMPK-TgPFKII axis essentially regulates protein lactylation in the zoonotic parasite Toxoplasma gondii. [Abstract]

2025 Feb 7:e0204424. PMID: 39918324
Food Sci Nutr

Lactucopicrin promotes fatty acid β-oxidation and attenuates lipid accumulation through adenosine monophosphate-activated protein kinase activation in free fatty acid-induced human hepatoblastoma cancer cells. [Abstract]

2024 Apr 18;12(8):5357-5372. PMID: 39139977
J Virol

PKM2 induces mitophagy through the AMPK-mTOR pathway promoting CSFV proliferation. [Abstract]

2024 Mar 19;98(3):e0175123. PMID: 38319105
J Virol

Human Cytomegalovirus Induces the Expression of the AMPKa2 Subunit to Drive Glycolytic Activation and Support Productive Viral Infection. [Abstract]

2020 Dec 2;95(5):e01321-20. PMID: 33268515
Cell Signal

AMPK impairment caused by gelatin disturbs mitochondrial dynamics leading to enhanced phagocytosis of bacteria in PMA-stimulated U937 cells. [Abstract]

2025 Nov:135:111985. PMID: 40653043
Cardiovasc Toxicol

Yoda1/Piezo1 Alleviates Lipopolysaccharide-Induced Cardiac Injury via AMPK-Mediated Mitophagy. [Abstract]

2025 Jul 24. PMID: 40705239
Cell Signal

Biliverdin alleviates cerebral ischemia-reperfusion injury by regulating the P4hb/MAPK/mTOR pathway to inhibit autophagy. [Abstract]

2025 Apr 19:111815. PMID: 40258578
Brain Res Bull

Metformin-induced mitophagy suppresses auditory hair cell apoptosis via AMPK pathway. [Abstract]

2025 Jan 16:111214. PMID: 39826756
Biochim Biophys Acta Mol Cell Res

Enhanced radiotherapy susceptibility in NSCLC through palbociclib-mediated PP5 inhibition. [Abstract]

2024 Nov 29:119884. PMID: 39617046
Brain Res Bull

Wogonin alleviates NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/SIRT1. [Abstract]

2024 Feb:207:110886. PMID: 38253131
Cytokine

Qinling liquid ameliorates renal immune inflammatory damage via activating autophagy through AMPK/Stat3 pathway in uric acid nephropathy. [Abstract]

2023 Mar:163:156120. PMID: 36630870
Brain Res Bull

Amarogentin has protective effects against sepsis-induced brain injury via modulating the AMPK/SIRT1/NF-κB pathway. [Abstract]

2022 Oct 15:189:44-56. PMID: 35985610
Brain Res Bull

DRD1 agonist A-68930 improves mitochondrial dysfunction and cognitive deficits in a streptozotocin-induced mouse model. [Abstract]

2021 Oct:175:136-149. PMID: 34284074
J Photochem Photobiol B

Photobiomodulation reduces hepatic lipogenesis and enhances insulin sensitivity through activation of CaMKKβ/AMPK signaling pathway. [Abstract]

2020 Dec;213:112075. PMID: 33152638
J Trauma Acute Care Surg

Role of autophagy and its molecular mechanisms in mice intestinal tract after severe burn. [Abstract]

2017 Oct;83(4):716-724. PMID: 28930963
Mol Cell Endocrinol

Hyperglycemia differentially regulates osteoblast and osteoclast autophagy via AMPK/mTOR/p70 S6K signaling in diabetic osteoporosis. [Abstract]

2026 May:615:112739. PMID: 41611117
Stem Cells

Catechin Promotes Osteogenic Differentiation via AMPK-mediated Autophagy Activation in Bone Marrow Mesenchymal Stem Cells. [Abstract]

2025 Dec 18:sxaf076. PMID: 41414661
Mol Cell Endocrinol

Vagotomy suppresses food intake by increasing GLP-1 secretion via the M3 AChR-AMPKα pathway in mice. [Abstract]

2025 Jan 21:599:112464. PMID: 39848433
Heliyon

Resistin alleviates lipopolysaccharide-induced inflammation in bovine alveolar macrophages by activating the AMPK/mTOR signaling pathway and autophagy. [Abstract]

2024 Sep 18;10(19):e38026. PMID: 39386884
Mol Cell Endocrinol

The glycolysis-related AMPK/ULK signaling pathway mediates the inhibitory effect of adiponectin in prostate cancer cells. [Abstract]

2024 Aug 8:112338. PMID: 39127402
Heliyon

Naringenin enhances the efficacy of ferroptosis inducers by attenuating aerobic glycolysis by activating the AMPK-PGC1α signalling axis in liver cancer. [Abstract]

2024 May 31;10(11):e32288. PMID: 38912485
Open Biol

Optogenetically engineered calcium oscillations promote autophagy-mediated cell death via AMPK activation. [Abstract]

2024 Apr;14(4):240001. PMID: 38653331
Mol Cell Endocrinol

Liraglutide promotes UCP1 expression and lipolysis of adipocytes by promoting the secretion of irisin from skeletal muscle cells. [Abstract]

2024 Jul 1:588:112225. PMID: 38570133
Heliyon

Knockdown of ACOT4 alleviates gluconeogenesis and lipid accumulation in hepatocytes. [Abstract]

2024 Mar 6;10(5):e27618. PMID: 38495177
Heliyon

Equisetin inhibits adiposity through AMPK-dependent regulation of brown adipocyte differentiation. [Abstract]

2024 Feb 1;10(3):e25458. PMID: 38327434
Heliyon

Luteolin improves vasoconstriction function and survival of septic mice via AMPK/NF-κB pathway. [Abstract]

2023 Jan 31;9(2):e13330. PMID: 36816271
Mol Cell Endocrinol

Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions. [Abstract]

2022 May 1:547:111598. PMID: 35157929
J Immunol Res

Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice. [Abstract]

2018 Dec 24:2018:9807139. PMID: 30671488

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Immunol Res. 2018 Dec 24:2018:9807139. [Abstract]

Western blot analysis of p-AMPK, AMPK, Bcl2 and Bax, LC3B and P62 expression in liver tissues.
Bone

Heparin affects human bone marrow stromal cell fate: Promoting osteogenic and reducing adipogenic differentiation and conversion. [Abstract]

2015 Sep;78:102-13. PMID: 25959412
Vascul Pharmacol

Growth differentiation factor 15 protects against diabetic endothelial dysfunction by AMP-activated protein kinase mediation. [Abstract]

2025 Oct 21:107554. PMID: 41130428
Microb Pathog

Regulatory mechanism of quercitrin on oxidative stress and histone acetylation changes in PRV infected 3D4/2 cells. [Abstract]

2025 Aug 5:208:107958. PMID: 40769227
Vet Res

Increased ROS levels activate AMPK-ULK1-mediated mitophagy to promote pseudorabies virus replication. [Abstract]

2025 Jul 21;56(1):156. PMID: 40691814
Mol Med Rep

Quercetin attenuates the symptoms of osteoarthritis in vitro and in vivo by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling. [Abstract]

2025 Mar;31(3):60. PMID: 39717946
Mol Med Rep

gCTRP3 inhibits oophorectomy‑induced osteoporosis by activating the AMPK/SIRT1/Nrf2 signaling pathway in mice. [Abstract]

2024 Aug;30(2):133. PMID: 38818814
Food Chem Toxicol

Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice. [Abstract]

2023 Nov:181:114089. PMID: 37804915
Exp Cell Res

von Hippel-Lindau-targeting microRNA-143-3p attenuates mitochondrial abnormality via AMPK/PGC-1α axis in Parkinson's disease. [Abstract]

2023 Aug 15;429(2):113684. PMID: 37307940
Clin Exp Hypertens

Ghrelin improves endothelial function and reduces blood pressure in Ang II-induced hypertensive mice: Role of AMPK. [Abstract]

2023 Dec 31;45(1):2208774. PMID: 37149883
Vet Res

Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis. [Abstract]

2023 Mar 14;54(1):25. PMID: 36918933
Med Oncol

Fibronectin type III domain-containing protein 5 promotes autophagy via the AMPK/mTOR signaling pathway in hepatocellular carcinoma cells, contributing to nab-paclitaxel chemoresistance. [Abstract]

2022 Dec 20;40(1):53. PMID: 36538123
Mol Med Rep

Angiotensin II receptor type 1 blocker candesartan improves morphine tolerance by reducing morphine‑induced inflammatory response and cellular activation of BV2 cells via the PPARγ/AMPK signaling pathway. [Abstract]

2022 Oct;26(4):318. PMID: 36004465
Food Chem Toxicol

Patulin disrupts SLC7A11-cystine-cysteine-GSH antioxidant system and promotes renal cell ferroptosis both in vitro and in vivo. [Abstract]

2022 Aug:166:113255. PMID: 35772596
Mol Med Rep

Neuroprotective effect of Ginsenoside Re against neurotoxin‑induced Parkinson's disease models via induction of Nrf2. [Abstract]

2022 Jun;25(6):215. PMID: 35543148
Food Chem Toxicol

Dietary prenylated flavonoid xanthohumol alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation. [Abstract]

2022 Feb:160:112813. PMID: 34999176
Mol Med Rep

Metformin inhibits cholesterol‑induced adhesion molecule expression via activating the AMPK signaling pathway in vascular smooth muscle cells. [Abstract]

2021 Oct;24(4):709. PMID: 34396446
Mol Med Rep

Trimetazidine improves hepatic lipogenesis and steatosis in non‑alcoholic fatty liver disease via AMPK‑ChREBP pathway. [Abstract]

2020 Sep;22(3):2174-2182. PMID: 32705195
Mol Med Rep

Hydrogen sulfide protects against high glucose‑induced lipid metabolic disturbances in 3T3‑L1 adipocytes via the AMPK signaling pathway. [Abstract]

2019 Nov;20(5):4119-4124. PMID: 31545435
Exp Cell Res

The Akt/mTOR cascade mediates high glucose-induced reductions in BDNF via DNMT1 in Schwann cells in diabetic peripheral neuropathy. [Abstract]

2019 Oct 1;383(1):111502. PMID: 31323191
Saudi Pharm J

Empagliflozin improves renal injury of diabetic nephropathy complicated with hyperuricemia through AMPK by promoting autophagy and inhibiting apoptosis. [Abstract]

2026 Jan 13;34(1):4. PMID: 41528619
Eur J Med Res

Low doses of ozone alleviate cardiomyocyte ferroptosis induced by hypoxia-reoxygenation injury via the AMPK-mTOR pathway. [Abstract]

2025 Jul 2;30(1):558. PMID: 40604957
Toxicol Appl Pharmacol

The skin photoprotective effect of trilinolein: Induction of cellular autophagy via the AMPK-mTOR signaling pathway. [Abstract]

2024 Feb:483:116836. PMID: 38272316
J Immunol

Glycolysis Induced by METTL14 Is Essential for Macrophage Phagocytosis and Phenotype in Cervical Cancer. [Abstract]

2024 Feb 15;212(4):723-736. PMID: 38197667
Toxicol Appl Pharmacol

Bidirectional crosstalk of the cAMP/ROS-dependent signaling pathways in inflammatory macrophage: An activation of formononetin. [Abstract]

2023 Aug 1:472:116571. PMID: 37269934
Toxicol Appl Pharmacol

Mogrol suppresses lung cancer cell growth by activating AMPK-dependent autophagic death and inducing p53-dependent cell cycle arrest and apoptosis. [Abstract]

2022 Jun 1;444:116037. PMID: 35489526
Acta Biochim Biophys Sin (Shanghai)

Evaluation of the immunomodulatory effects of C9-13-CPs in macrophages. [Abstract]

2021 Aug 31;53(9):1154-1165. PMID: 34355237
Andrology

Simvastatin alleviated diabetes mellitus-induced erectile dysfunction in rats by enhancing AMPK pathway-induced autophagy. [Abstract]

2020 May;8(3):780-792. PMID: 31955524
Andrology

In vitro exposure to metformin activates human spermatozoa at therapeutically relevant concentrations. [Abstract]

2020 May;8(3):663-670. PMID: 31944615
Acta Biochim Biophys Sin (Shanghai)

Ginsenoside Rg1 inhibits apoptosis by increasing autophagy via the AMPK/mTOR signaling in serum deprivation macrophages. [Abstract]

2018 Feb 1;50(2):144-155. PMID: 29324976

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2018 Feb 1;50(2):144-155. [Abstract]

Raw264.7 macrophages with serum deprivation are treated with 50 μM Rg1 for 48 h in absence or presence of compound C (10 mM) or AICAR (250 μM). Western blots of the protein expressions of Atg5, Beclin1, LC3, and p62/SQSMT1.
Am J Physiol Gastrointest Liver Physiol

N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation. [Abstract]

2024 Jun 1;326(6):G697-G711. PMID: 38591127
Biochim Biophys Acta Mol Cell Biol Lipids

Palmitic acid activates NLRP3 inflammasome through NF-κB and AMPK-mitophagy-ROS pathways to induce IL-1β production in large yellow croaker (Larimichthys crocea). [Abstract]

2024 Mar;1869(2):159428. PMID: 38029958
Endocrinology

MiR-143 targets SYK to regulate NEFA uptake and contribute to thermogenesis in male mice. [Abstract]

2023 Aug 1;164(9):bqad114. PMID: 37486737
Biochim Biophys Acta Mol Cell Biol Lipids

Acteoside improves adipocyte browning by CDK6-mediated mTORC1-TFEB pathway. [Abstract]

2023 Sep;1868(9):159364. PMID: 37433343
Psychopharmacology (Berl)

Dopamine D1 receptors mediate methamphetamine-induced dopaminergic damage: involvement of autophagy regulation via the AMPK/FOXO3A pathway. [Abstract]

2022 Mar;239(3):951-964. PMID: 35190859
Front Oncol

Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Catrcinoma by Inhibiting IL-6 Signaling Pathway. [Abstract]

2021 Nov 22;11:762523. PMID: 34881181
Front Oncol

NRBP2 Functions as a Tumor Suppressor and Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer. [Abstract]

2021 Mar 18:11:634026. PMID: 33816275
Photochem Photobiol Sci

Schisandrin A alleviates UVB-induced photoaging via AMPK/Nrf2-mediated antioxidant and autophagy pathways. [Abstract]

2026 Apr;25(4):613-628. PMID: 41801672
J Pharm Pharmacol

Advanced oxidation protein products accelerates paracetamol-induced liver injury through AMPK-mTOR signaling pathway in chronic kidney disease. [Abstract]

2025 Aug 19:rgaf069. PMID: 40828098
Cell Stress Chaperones

Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis. [Abstract]

2024 Jun;29(3):440-455. PMID: 38653383
IUBMB Life

Ferulic acid ameliorates acetaminophen-induced acute liver injury by promoting AMPK-mediated protective autophagy. [Abstract]

2022 Sep;74(9):880-895. PMID: 35514074
Cytotherapy

Sirtuin 6 regulates macrophage polarization to alleviate sepsis-induced acute respiratory distress syndrome via dual mechanisms dependent on and independent of autophagy. [Abstract]

2022 Feb;24(2):149-160. PMID: 34920961
Hum Exp Toxicol

Methylphenidate exerts neuroprotective effects through the AMPK signaling pathway. [Abstract]

2021 Sep;40(9):1422-1433. PMID: 33660552
Vet J

Pinobanksin alleviates 4℃ semen preservation-induced oxidative damage and apoptosis in Wenchang Pig spermatozoa via the CaMKKβ/AMPK/Nrf2 pathway. [Abstract]

2026 Apr:316:106599. PMID: 41698643
Front Biosci (Landmark Ed)

Neuroprotective Effects of the SIRT3/AMPK Axis in Experimental Glaucoma. [Abstract]

2026 Jan 14;31(1):46525. PMID: 41609094
J Dent Sci

2025 Dec 24.
Front Biosci (Landmark Ed)

Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction. [Abstract]

2025 Jan 20;30(1):25565. PMID: 39862078
Funct Integr Genomics

Tet1-mediated activation of the Ampk signaling by Trpv1 DNA hydroxymethylation exerts neuroprotective effects in a rat model of Parkinson's disease. [Abstract]

2024 Sep 17;24(5):161. PMID: 39285026
Int J Food Sci Tech

2024 Jul 18.
Adipocyte

Salvianolic acid A promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes through regulation of the AMPK-PGC1α signalling pathway. [Abstract]

2022 Dec;11(1):562-571. PMID: 36053001
J Leukoc Biol

Bone marrow microenvironment drives AML cell OXPHOS addiction and AMPK inhibition to resist chemotherapy. [Abstract]

2022 Aug;112(2):299-311. PMID: 34927743
Cell Biol Int

Bone marrow mesenchymal stem cells inhibit cardiac hypertrophy by enhancing FoxO1 transcription. [Abstract]

2021 Jan;45(1):188-197. PMID: 33049085
J Neuropathol Exp Neurol

Downregulating Cdk5 reverses hippocampal neuron ferroptosis by regulating the AMP-activated protein kinase pathway and "M1" polarized microglia. [Abstract]

2025 Aug 19:nlaf092. PMID: 40829042
J Tradit Complement Med

Nao-Xin-Qing tablet inhibits macrophage inflammatory response in atherosclerosis via AMPK-α/SIRT1/PPAR-γ pathway. [Abstract]

2024 Jul 26;15(5):536-547. PMID: 40979481
FEBS Lett

LKB1/AMPK axis crosstalks with Wnt/β-catenin signaling in cancer via the deubiquitinase USP10. [Abstract]

2023 Dec;597(24):3061-3071. PMID: 37873736
Arch Biochem Biophys

Exogenous galanin alleviates hepatic steatosis by promoting autophagy via the AMPK-mTOR pathway. [Abstract]

2023 Aug:744:109689. PMID: 37429535
Arch Biochem Biophys

Handelin protects human skin keratinocytes against ultraviolet B-induced photodamage via autophagy activation by regulating the AMPK-mTOR signaling pathway. [Abstract]

2023 Jul 15:743:109646. PMID: 37225010
Arch Biochem Biophys

N-butyrate increases heat shock protein 70 through heat shock factor 1 and AMP-activated protein kinase pathways in human intestinal Caco-2 cells. [Abstract]

2023 Mar 1:736:109525. PMID: 36702450
Immunopharmacol Immunotoxicol

Sestrin2 suppresses ferroptosis to alleviate septic intestinal inflammation and barrier dysfunction. [Abstract]

2023 Apr;45(2):123-132. PMID: 36066109
Immunopharmacol Immunotoxicol

The AMPK-SIRT1-FoxO1-NF-κB signaling pathway participates in hesperetin-mediated neuroprotective effects against traumatic brain injury via the NLRP3 inflammasome. [Abstract]

2022 Dec;44(6):970-983. PMID: 35786120
Diabetes Metab Syndr Obes

Empagliflozin Regulates the AdipoR1/p-AMPK/p-ACC Pathway to Alleviate Lipid Deposition in Diabetic Nephropathy. [Abstract]

2021 Jan 18:14:227-240. PMID: 33500643
Br J Nutr

The protein-sparing effect of α-lipoic acid in juvenile grass carp, Ctenopharyngodon idellus: effects on lipolysis, fatty acid β-oxidation and protein synthesis. [Abstract]

2018 Nov;120(9):977-987. PMID: 30198455
Oral Dis

Trehalose Alleviates the Advancement of Temporomandibular Joint Osteoarthritis via Regulating the AMPK/ULK1 Autophagy Pathway. [Abstract]

2025 Oct 22. PMID: 41123079
Acta Diabetol

FTZ alleviates lipid deposition in diabetic kidney disease by AMPK/ACC/SREBP signaling pathway. [Abstract]

2025 Apr 1. PMID: 40167639
Free Radic Res

Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis. [Abstract]

2024 Dec 28:1-14. PMID: 39731709
Toxicol Lett

Down-regulation of O-GlcNAcylation alleviates insulin signaling pathway impairment following arsenic exposure via suppressing the AMPK/mTOR-autophagy pathway. [Abstract]

2024 May 9:397:67-78. PMID: 38734222
J Anim Sci

Metformin improves fish sperm quality by regulating glucose uptake capacity during in vitro storage. [Abstract]

2023 Jan 3:101:skad152. PMID: 37191447
Cell Immunol

Narciclasine ameliorated T cell mediated acute liver injury through activating AMPK pathway. [Abstract]

2022 Dec:382:104631. PMID: 36272268
Cell Tissue Res

Sulforaphane delays diabetes-induced retinal photoreceptor cell degeneration. [Abstract]

2020 Dec;382(3):477-486. PMID: 32783101
Metallomics

AMPK mediates the neurotoxicity of iron oxide nanoparticles retained in mitochondria or lysosomes. [Abstract]

2019 Jul 17;11(7):1200-1206. PMID: 31241124
J Appl Toxicol

Capacitation-Induced Changes in Sperm Motility, AMPK Phosphorylation, and Tyrosine Phosphorylation Are Diminished by Therapeutically Relevant Concentrations of Metformin. [Abstract]

2026 Feb 2. PMID: 41628886
J Orthop Surg Res

The increase in autophagy induced by naringin alleviates Schwann cell apoptosis mediated by the AMPK/mTOR signalling pathway. [Abstract]

2025 Jun 4;20(1):566. PMID: 40462169
J Biochem Mol Toxicol

β-Sitosterol Ameliorates Ulcerative Colitis Through Modulation of the AMPK/MLCK Anti-Inflammatory Pathway. [Abstract]

2025 Jun;39(6):e70287. PMID: 40400313
J Biochem Mol Toxicol

Lycopene Ameliorates Polycystic Ovary Syndrome in Rats by Inhibiting Ovarian Ferroptosis Through Activation of the AMPK/Nrf2 Pathway. [Abstract]

2025 Feb;39(2):e70158. PMID: 39871526
Mol Pain

Mitochondria-derived peptide is an effective target for treating streptozotocin induced painful diabetic neuropathy through induction of activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator 1alpha -mediated mitochondrial biogenesis. [Abstract]

2024 Jan-Dec:20:17448069241252654. PMID: 38658141
Mol Biol Rep

Dapagliflozin promotes browning of white adipose tissue through the FGFR1-LKB1-AMPK signaling pathway. [Abstract]

2024 Apr 21;51(1):562. PMID: 38644407
Int J Biochem Cell Biol

YAP upregulates AMPKα1 to induce cancer cell senescence. [Abstract]

2024 May:170:106559. PMID: 38499237
J Orthop Surg Res

Diallyl trisulfide improves spinal cord ischemia-reperfusion injury damage by activating AMPK to stabilize mitochondrial function. [Abstract]

2023 Nov 6;18(1):838. PMID: 37932742
Genes (Basel)

AMPK Promotes Larval Metamorphosis of Mytilus coruscus. [Abstract]

2022 Dec 16;13(12):2384. PMID: 36553651
Reprod Toxicol

Melatonin attenuates di-(2-ethylhexyl) phthalate-induced apoptosis of human granulosa cells by inhibiting mitochondrial fission. [Abstract]

2022 Oct:113:18-29. PMID: 35952901
Int J Biochem Cell Biol

Trehalose induces B cell autophagy to alleviate myocardial injury via the AMPK/ULK1 signalling pathway in acute viral myocarditis induced by Coxsackie virus B3. [Abstract]

2022 May;146:106208. PMID: 35381374
Int J Biochem Cell Biol

Etoposide-induced protein 2.4 ameliorates high glucose-induced epithelial-mesenchymal transition by activating adenosine monophosphate-activated protein kinase pathway in renal tubular cells. [Abstract]

2022 Jan:142:106117. PMID: 34801707
Mol Biol Rep

Effects of valerate on intestinal barrier function in cultured Caco-2 epithelial cell monolayers. [Abstract]

2022 Mar;49(3):1817-1825. PMID: 34837149
Exp Physiol

Danthron attenuates experimental atherosclerosis by targeting foam cell formation. [Abstract]

2021 Mar;106(3):653-662. PMID: 33450102
J Biochem Mol Toxicol

Autophagy induction and antiproliferative effect of a novel curcumin derivative MOMI-1 on the human lung cancer cells A549. [Abstract]

2019 Apr;33(4):e22280. PMID: 30485594
J Cell Biochem

Adiponectin receptor agonist AdipoRon attenuates calcification of osteoarthritis chondrocytes by promoting autophagy. [Abstract]

2020 Jun;121(5-6):3333-3344. PMID: 31898335
Mol Biol Rep

L-Arginine alleviates heat stress-induced intestinal epithelial barrier damage by promoting expression of tight junction proteins via the AMPK pathway. [Abstract]

2019 Dec;46(6):6435-6451. PMID: 31576512
J Integr Neurosci

Deciphering the Role of N-Acetyltransferase 10 in Thalamic Hemorrhage Through Integrative Multi-Omics and Experimental Validation. [Abstract]

2025 Nov 21;24(11):44643. PMID: 41351448
Exp Eye Res

Astragalus polysaccharide protects mouse cornea from type 1 diabetes and activates AMPK-dependent autophagy. [Abstract]

2025 Oct 16:262:110698. PMID: 41109591
Toxicol Mech Methods

Propofol alleviates traumatic brain injury through regulating Th17/Treg balance by activation of the AMPK/SIRT1 pathway. [Abstract]

2025 Apr 2:1-11. PMID: 40172234
Anal Cell Pathol

Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis. [Abstract]

2024 Oct 29:2024:7752299. PMID: 39502521
Arch Physiol Biochem

Mangiferin prevents glucolipotoxicity-induced pancreatic beta-cell injury through modulation of autophagy via AMPK-mTOR signaling pathway. [Abstract]

2024 Sep 3:1-10. PMID: 39225043
BMC Pharmacol Toxicol

Rotenone activates the LKB1-AMPK-ULK1 signaling pathway to induce autophagy and apoptosis in rat thoracic aortic endothelial cells. [Abstract]

2024 May 23;25(1):33. PMID: 38783387
BMC Pharmacol Toxicol

Bisdemethoxycurcumin alleviates LPS-induced acute lung injury via activating AMPKα pathway. [Abstract]

2023 Nov 20;24(1):63. PMID: 37986186
Immun Inflamm Dis

Naringenin ameliorates collagen-induced arthritis through activating AMPK-mediated autophagy in macrophages. [Abstract]

2023 Oct;11(10):e983. PMID: 37904715
Exp Biol Med

Corilagin alleviates intestinal ischemia/reperfusion injury by relieving oxidative stress and apoptosis via AMPK/Sirt1-autophagy pathway. [Abstract]

2023 Feb;248(4):317-326. PMID: 36680375
Animals (Basel)

FGF21 Reduces Lipid Accumulation in Bovine Hepatocytes by Enhancing Lipid Oxidation and Reducing Lipogenesis via AMPK Signaling. [Abstract]

2022 Apr 6;12(7):939. PMID: 35405926
Biotechnol Appl Biochem

Gemcitabine induces apoptosis and autophagy via the AMPK/mTOR signaling pathway in pancreatic cancer cells. [Abstract]

2018 Sep;65(5):665-671. PMID: 29575133
PLoS One

Curcumin ameliorates aging-induced blood-testis barrier disruption by regulating AMPK/mTOR mediated autophagy. [Abstract]

2025 Apr 24;20(4):e0321752. PMID: 40273194
Int J Immunopathol Pharmacol

Low-dose metformin suppresses hepatocellular carcinoma metastasis via the AMPK/JNK/IL-8 pathway. [Abstract]

2024 Jan-Dec:38:3946320241249445. PMID: 38679570
Rejuvenation Res

Alginate oligosaccharides enhance autophagy to rejuvenate H2O2-induced senescent IEC-6 through the AMPK/mTOR signaling pathway. [Abstract]

2023 Jun;26(3):116-124. PMID: 36943260
PLoS One

NorUDCA promotes degradation of α1-antitrypsin mutant Z protein by inducing autophagy through AMPK/ULK1 pathway. [Abstract]

2018 Aug 1;13(8):e0200897. PMID: 30067827

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: PLoS One. 2018 Aug 1;13(8):e0200897. [Abstract]

Phosphorylation of AMPK (Thr172) in HTOZ cells pretreated with Compound C at different concentrations (0-20 μM) for 1 hour prior to the presence of norUDCA at 200 μM for additional 1 hour is determined by western blotting analyses.
Clin Exp Pharmacol Physiol

Gemfibrozil Prevents Myocardial Ischemia-Reperfusion Injury in Mice Through AMPK Activation. [Abstract]

2026 Feb;53(2):e70106. PMID: 41702849
Electron J Biotechnol

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2018 Oct;72(4):167-175. PMID: 29979351

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Cardiovasc Pharmacol. 2018 Oct;72(4):167-175. [Abstract]

Foam cells are incubated with or without Compound C (10 μM) before the addition of CTRP9. According to the Western blot, the relative protein levels of p-AMPK, p-mTOR, LC3 II, and p62 are analyzed, respectively.
Biochem Biophys Res Commun

High glucose downregulates the effects of autophagy on osteoclastogenesis via the AMPK/mTOR/ULK1 pathway. [Abstract]

2018 Sep 5;503(2):428-435. PMID: 29649480

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 5;503(2):428-435. [Abstract]

Western blotting showing AMPK/m-TOR/ULK1 pathway relative protein (AMPK, p-AMPK, mTOR, p-mTOR, ULK1 and p-ULK1) levels in low glucose (LG), LG+Compound C (CC), HG and HG+CC groups.
Biochem Biophys Res Commun

Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis. [Abstract]

2017 Dec 9;494(1-2):278-284. PMID: 29024627
Liver Res

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2025 Apr 15;9(2):157-168. PMID: 40620498
Connect Tissue Res

Creatine promotes osteogenic differentiation of dental pulp stem cells via the AMPK-ULK1-autophagy axis. [Abstract]

2025 Feb 11:1-14. PMID: 39930963
Eur J Histochem

Irisin suppresses PDGF-BB-induced proliferation of vascular smooth muscle cells in vitro by activating AMPK/mTOR-mediated autophagy. [Abstract]

2024 Oct 15;68(4). PMID: 39410813
Endocr J

Rutin promotes white adipose tissue "browning" and brown adipose tissue activation partially through the calmodulin-dependent protein kinase kinase β/AMP-activated protein kinase pathway. [Abstract]

2022 Apr 28;69(4):385-397. PMID: 34719526
Biochem Cell Biol

Ginsenoside metabolite compound K induces apoptosis and autophagy in non-small cell lung cancer cells via AMPK-mTOR and JNK pathways. [Abstract]

2019 Aug;97(4):406-414. PMID: 30475650
Med Sci Monit

Peroxisome Proliferator-Activated Receptor (PPARγ) Plays a Protective Role in Cigarette Smoking-Induced Inflammation via AMP-Activated Protein Kinase (AMPK) Signaling. [Abstract]

2018 Jul 25:24:5168-5177. PMID: 30044769

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Med Sci Monit. 2018 Jul 25:24:5168-5177. [Abstract]

The levels of p-S6K and S6K in 16HBE cells after treatment of BRL 49653/Troglitazone or/and Compound C are detected by western blot. The levels of p62 and LC3 in 16HBE cells after treatment of BRL 49653/Troglitazone or/and Compound C are detected by western blot.
Prostate Cancer

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2025 Sep 30:2025:8843174. PMID: 41064475
J Radiat Res

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2025 Apr 14:rraf015. PMID: 40223639
Curr Eye Res

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2025 Jun;50(6):600-609. PMID: 39988428
Neurosci Lett

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2023 Sep 25:814:137471. PMID: 37673371
Physiol Res

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2020 Nov 16;69(5):813-822. PMID: 32901500
Neurosci Lett

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2019 Nov 1;712:134485. PMID: 31499136
Cell Physiol Biochem

PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes. [Abstract]

2018;50(5):1891-1902. PMID: 30396162

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2018;50(5):1891-1902. [Abstract]

AMPK inhibitor dorsomorphin treatment reduces the protein expression of PGC-1α.
Cell Physiol Biochem

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2018;48(1):227-236. PMID: 30007970

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2018;48(1):227-236. [Abstract]

Inhibition of AMPK with Compound C (CC) attenuates the protective effects of FNDC5 on the oxLDL-induced AMPK dephosphorylation and fibrosis in LX-2 cells.
Cell Physiol Biochem

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2016;40(3-4):499-508. PMID: 27889761
J Herb Med

2025 Nov 26.
Int J Ophthalmol

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2026 Feb 18;19(2):219-229. PMID: 41573007
Cardiol Res Pract

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Neurobiol Learn Mem

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2021 Jul;182:107463. PMID: 34015440
J Interferon Cytokine Res

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2020 Mar;40(3):145-151. PMID: 31916911
Cytotechnology

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2026 Apr;78(2):63. PMID: 41868711
Biol Pharm Bull

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2022 Sep 1;45(9):1276-1282. PMID: 35732438
Am J Transl Res

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2020 Jul 15;12(7):3329-3345. PMID: 32774703
Am J Transl Res

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2018 Oct 15;10(10):3086-3098. PMID: 30416652
Nutr Res Pract

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2024 Aug;18(4):479-497. PMID: 39109201
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2022 Oct 17;55:e12040. PMID: 36259797
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Neurochirurgie

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2024 Dec;44(1):2321651. PMID: 38466134
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2026 Mar 5;32(2):239-246.
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2023 Jan 24.
University of Milan

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December 2nd, 2022.
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December 19th, 2022.
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2021 Dec 3:2021:3119953. PMID: 34900084
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2021 Oct 5;2021:8542809. PMID: 34650665
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2020 Nov 12;2020:7374086. PMID: 33274005
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2020 Apr 30;2020:7826874. PMID: 32419825
Oxid Med Cell Longev

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2020 May 16;2020:6384803. PMID: 32509148
Oxid Med Cell Longev

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2019 Oct 15;2019:8783197. PMID: 31885823
Oncotarget

MACC1 mediates acetylcholine-induced invasion and migration by human gastric cancer cells. [Abstract]

2016 Apr 5;7(14):18085-94. PMID: 26919111

Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 Apr 5;7(14):18085-94. [Abstract]

MACC1 is up-regulated by ACh through p-AMPK. A. ACh stimulates AMPK phosphorylation via M3R. B. Inhibition of AMPK activity by Dorsomorphin (8 μM) suppresses the induction of MACC1 expression by ACh. p-AMPK levels increase after ACh stimulation, and pretreatment of UK-88525 attenuates the ACh-induced increase of p-AMPK.

Solvant et solubilité

In Vitro:

H₂O : 100 mg/mL (211.68 mM; Need ultrasonic)

DMSO : 5 mg/mL (10.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1168 mL

10.5840 mL

21.1681 mL

5 mM

0.4234 mL

2.1168 mL

4.2336 mL

10 mM

0.2117 mL

1.0584 mL

2.1168 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 20 mg/mL (42.34 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

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Working solution concentration: 0.22 mg/mL

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Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

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Références

[1]. Zhou G, et al. Role of AMP-activated protein kinase in mechanism of action. J Clin Invest. 2001 Oct;108(8):1167-74. [Content Brief]

[2]. Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7(9):e45845. [Content Brief]

[3]. Yu PB, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan;4(1):33-41. [Content Brief]

[4]. Kim YM, et al. Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo. Atherosclerosis. 2011 Nov;219(1):57-64. [Content Brief]

[5]. Guo Y, et al. AMPK inhibition blocks ROS-NFκB signaling and attenuates endotoxemia-induced liver injury. PLoS One. 2014 Jan 24;9(1):e86881. [Content Brief]

[6]. Zhang Y, et al. Urolithin A suppresses glucolipotoxicity-induced ER stress and TXNIP/NLRP3/IL-1β inflammation signal in pancreatic β cells by regulating AMPK and autophagy. Phytomedicine. 2021 Dec;93:153741. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	2.1168 mL	10.5840 mL	21.1681 mL	52.9201 mL
	5 mM	0.4234 mL	2.1168 mL	4.2336 mL	10.5840 mL
	10 mM	0.2117 mL	1.0584 mL	2.1168 mL	5.2920 mL
H₂O	15 mM	0.1411 mL	0.7056 mL	1.4112 mL	3.5280 mL
	20 mM	0.1058 mL	0.5292 mL	1.0584 mL	2.6460 mL
	25 mM	0.0847 mL	0.4234 mL	0.8467 mL	2.1168 mL
	30 mM	0.0706 mL	0.3528 mL	0.7056 mL	1.7640 mL
	40 mM	0.0529 mL	0.2646 mL	0.5292 mL	1.3230 mL
	50 mM	0.0423 mL	0.2117 mL	0.4234 mL	1.0584 mL
	60 mM	0.0353 mL	0.1764 mL	0.3528 mL	0.8820 mL
	80 mM	0.0265 mL	0.1323 mL	0.2646 mL	0.6615 mL
	100 mM	0.0212 mL	0.1058 mL	0.2117 mL	0.5292 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Dorsomorphin dihydrochloride

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Dorsomorphin dihydrochloride

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Dorsomorphin dihydrochloride Related Classifications

Cat. No.: HY-13418