ETNK2 - ethanolamine kinase 2 Gene

Also Known as EKI2; HMFT1716

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55224

About ETNK2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:204,131,062-204,152,044 (from NCBI)

This gene has 11 transcripts (splice variants), 215 orthologues and 3 paralogues. Biased expression in testis (RPKM 38.7), liver (RPKM 35.9) and 9 other tissues.

Summary

The protein encoded by this gene is a member of choline/ethanolamine kinase family which catalyzes the first step of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate (CDP) ethanolamine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

ETNK2 Products (4)

mRNA Protein Name
NM_001297760.2 NP_001284689.1 ethanolamine kinase 2 isoform 2
NM_001297761.2 NP_001284690.1 ethanolamine kinase 2 isoform 3
NM_001297762.2 NP_001284691.1 ethanolamine kinase 2 isoform 4
NM_018208.4 NP_060678.2 ethanolamine kinase 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ETNK2 Protein Structure

Choline_kinase

Choline_kinase: Choline/ethanolamine kinase (107 - 300)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

ethanolamine kinase 2

  • ethanolamine kinase-like protein

ETNK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
ETNK2 Q9NVF9 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
ETNK2 Q9NVF9 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
ETNK2 Q9NVF9 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
ETNK2 Q9NVF9 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra
ETNK2 Q9NVF9 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra
ETNK2 Q9NVF9 ATN1 Homo sapiens Q86V38
Y2H Prey Pooling
32296183
Intra
ETNK2 Q9NVF9 ATN1 Homo sapiens Q86V38
Y2H Array
32296183
Intra
ETNK2 Q9NVF9 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
ETNK2 Q9NVF9 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
ETNK2 Q9NVF9 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
32296183
Intra
ETNK2 Q9NVF9 HNRNPK Homo sapiens P61978-2
Y2H Array
32296183
Intra
ETNK2 Q9NVF9 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
ETNK2 Q9NVF9 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Prostate Carcinoma In Situ

  • Carcinoma In Situ Of Prostate

  • Grade Iii Pin

  • Pin Iii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04560 ETNK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ETNK2 RGD RGD:1305304
Canis familiaris ETNK2 VGNC VGNC:40493
Mus musculus ETNK2 MGD MGI:2443760
Macaca mulatta ETNK2 VGNC VGNC:72353
Felis catus ETNK2 VGNC VGNC:61979
Bos taurus ETNK2 VGNC VGNC:28625
Others ETNK2 NCBI