H-D-Tpi-OH
H-D-Tpi-OH (D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid) is a tetrahydro-β-carboline derivative. H-D-Tpi-OH only slightly upregulates QR1, mildly inhibits the aromatase and NO synthesis pathways, and shows no significant in vitro anti-breast tumor proliferation activity. H-D-Tpi-OH can be used in cancer-related research.
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- CAS No.: 72002-54-1
- Formule: C12H12N2O2
- Masse moléculaire:216.24
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
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Aromatase |
iNOS |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | Survival |
95.4 %
Compound: 1b
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Inhibition of TNF-alpha-induced NFkappaB activation in human HEK293 cells assessed as cell survival at 50 uM after 6 hrs by luciferase assay relative to control
Inhibition of TNF-alpha-induced NFkappaB activation in human HEK293 cells assessed as cell survival at 50 uM after 6 hrs by luciferase assay relative to control
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[PMID: 21978950] |
| RAW | Survival |
95.9 %
Compound: 1b
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Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells assessed as cell survival at 50 uM pretreated 15 mins before LPS challenge measured after 20 hrs relative to control
Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells assessed as cell survival at 50 uM pretreated 15 mins before LPS challenge measured after 20 hrs relative to control
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[PMID: 21978950] |
H-D-Tpi-OH (compound 1b) only exhibits weak QR1-inducing activity (IR=0.8), 34.9% aromatase inhibitory effect and 3.5% nitric oxide production inhibition, and lacks significant NF-κB inhibitory activity and MCF7 cell proliferation inhibitory activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 72002-54-1
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Masse moléculaire 216.24
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Formule C12H12N2O2
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SMILES
C(O)(=O)[C@H]1CC=2C=3C(NC2CN1)=CC=CC3
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Synonyms
D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
H-D-Tpi-OH Related Classifications
HY-W269285 Related Classifications
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