HDAC1 activator-1
HDAC1 activator-1 is a specific HDAC1 activator with orally activity, exerting no significant effects on other HDAC family members. HDAC1 activator-1 exhibits neuroprotective activity, ameliorates cognitive and motor function deficits by reducing neuronal loss and gliosis. HDAC1 activator-1 specifically activates HDAC1 in SH-SY5Y cells and exerts regulatory effects on aberrant cell cycle and DNA damage. HDAC1 activator-1 can be used for the research of TDP-43 proteinopat1-related neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS) and cerebral ischemia-related neurological injury.
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- CAS No.: 300399-36-4
- Formule: C17H24O4
- Masse moléculaire:292.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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HDAC1 |
HDAC1 Activator-1 (cpd 5104434) (1 μM-50 μM) shows dose-dependent activation of HDAC1 enzymatic activity, with no significant effects on HDAC2, HDAC3, and HDAC8, exhibiting high selectivity for HDAC1[1][2].
HDAC1 Activator-1 (1 μM-50 μM; 72 h) specifically activates HDAC1 in the human neuroblastoma cell line SH-SY5Y in vitro[1][2].
HDAC1 Activator-1 (2.5 μM, 25 μM) restores HDAC1 enzymatic activity in primary cortical neurons subjected to oxygen-glucose deprivation (OGD)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human neuroblastoma SH-SY5Y cell line
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Concentration:1 μM, 10 μM, 50 μM
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Incubation Time:72 h
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Result:Enhances HDAC1 deacetylation function without altering its protein expression.
HDAC1 Activator-1 (6 mg/kg; i.p.; 5 days a week; for 2 months) ameliorates cognitive deficits (Morris water maze, novel object recognition test) and motor dysfunction (rotarod test), reverses aberrant cell cycle, DNA damage, neuronal loss and gliosis in FTLD-TDP transgenic mice[1][2].
HDAC1 Activator-1 (6 mg/kg; i.p.; 5 days a week; for 2 months) ameliorates cognitive deficits (Morris water maze, novel object recognition test) and motor dysfunction (rotarod test), reverses aberrant cell cycle, DNA damage, neuronal loss and gliosis in FTLD-TDP transgenic mice[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female and male FTLD-TDP transgenic (Tg) mice (6 months old) and age-matched wild-type (WT) FVB mice[1].
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Dosage:6 mg/kg, 30 mg/kg, 0.3 mg/kg
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Administration:Intraperitoneal (IP); 5 days a week; for 1-2 months
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Result:Demonstrated significant improvement in cognitive function and motor function.
Restored nuclear HDAC1 activity and reduced acetyl-histone H3 (Lys9/14) levels.
Reversed aberrant cell cycle activity (downregulated E2F1, PCNA, p21) and attenuated DNA damage.
Alleviated neuronal loss and inhibited gliosis.
No significant toxicity (no impact on cell viability, hepatotoxicity, renotoxicity, or body weight).
Chemical Information
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CAS No. 300399-36-4
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Masse moléculaire 292.37
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Formule C17H24O4
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SMILES
O=C1C(CC2C(CC(C)(CC2=O)C)=O)=C(CC(C)(C1)C)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC1 activator-1 Related Classifications
HY-186073 Related Classifications
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- HDAC1 activator-1
- 300399-36-4
- HDAC
- HDAC1 activator
- neuroprotective activity
- inhibits aberrant cell cycle
- DNA damage
- reduces neuronal loss and gliosis
- ameliorates cognitive and motor function deficits
- TDP-43 proteinopathies
- amyotrophic lateral sclerosis (ALS)
- cerebral ischemia
- neurodegenerative diseases
- SH-SY5Y cell line
- HEK-293T cell line
- primary cortical neurons
- frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-TDP) transgenic mice
- rat model of cerebral ischemia
- mouse model of neurodegeneration
- Inhibitor
- inhibitor
- inhibit