NSC 689534
Based on 1 publication(s) in Google Scholar
NSC 689534 can form copper chelate with Cu2+. NSC 689534/Cu2+ complex is a potent oxidative stress inducer, and has antitumor activity.
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- Pureté: 96.31%
- CAS No.: 907958-80-9
- Formule: C19H18N6S
- Masse moléculaire:362.45
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) NSC 689534
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Activité biologique
Description
In Vitro
NSC 689534/Cu2+ complex (48 h) inhibits cell viability of HL60 and PC3 cell with IC50s of 0.2 and 0.4 μM respectively, which is about 4 times more potent than NSC 689534 alone[1].
NSC 689534/Cu2+ complex (2.5 μM, 24 h) induces oxidative stress and depletes GSH in PC3 cells, whereas with no effect by NSC 689534 alone[1].
NSC 689534/Cu2+ complex (2.5 μM, 24 h) induces macroautophagy (indicated by LC3 accumulation into large autophagosomes) and an ER-stress response (upregulation of GRP78 and CHOP) in PC3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 907958-80-9
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Appearance Solid
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Masse moléculaire 362.45
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Formule C19H18N6S
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Color Light yellow to yellow
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SMILES
S=C(N(CC1=NC=CC=C1)CC2=NC=CC=C2)N/N=C/C3=NC=CC=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Front Biosci (Landmark Ed)
Novel Signaling Pathway and NSC689534 as a Potential Drug Candidate for Cutaneous Squamous Cell Carcinoma. [Abstract]2024 Jan 17;29(1):19. PMID: 38287820
Pureté et documentation
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Fiche technique (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Chad N Hancock, et al. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21. [Content Brief]
[2]. Hancock CN, et al. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NSC 689534 Related Classifications
HY-156780 Related Classifications
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