SMYD3-IN-2
SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer.
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- Formule: C26H21BrN2O4
- Masse moléculaire:505.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Voir tous les produits spécifiques à Isoform Histone Methyltransferase
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Activité biologique
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SMYD3 0.81 μM μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| BGC-823 | IC50 |
0.75 μM
Compound: 7r
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Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation by MTT assay
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[PMID: 36527933] |
SMYD3-IN-2 (compound 7r) (1.0 μM) exhibits potent inhibitory capacity against SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively[1].
SMYD3-IN-2 (1.0 μM; 24 h) can suppress Akt methylation and activation by SMYD3[1].
SMYD3-IN-2 (0-48 h) suppresses the proliferation of BGC823 stomach adenocarcinoma cells by inducing autophagic cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BGC823 cells
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Concentration:1.0 μM
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Incubation Time:24 h
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Result:Suppressed the methylation levels of H3K4 and could significantly inhibit the lysine methylation of Akt1 by SMYD3.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Xenograft Balb/c nude mice models[1]
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Dosage:15 and 30 mg/kg
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Administration:Intraperitoneally administration
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Result:Remarkably suppressed the tumor volume, tumor weight and growth curves of gastric cancer xenografts in a dose-dependent manner.
Resulted in strong immunohistochemistry staining of LC3-II and p62, weak staining of p-Akt (T308) and Ki67.
Chemical Information
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Masse moléculaire 505.36
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Formule C26H21BrN2O4
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SMILES
[H][C@]12CN(C([C@]1(O[C@@]3([C@@H]2C4=CC=C(C=C4)Br)C(NC5=CC=CC=C53)=O)O)=O)CC6=CC=CC=C6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SMYD3-IN-2 Related Classifications
HY-152228 Related Classifications
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