SYK-1106
SYK-1106 is a potent delta-opioid receptor (DOR) agonist with an EC50 of 89 pM and a Ki of 848 pM. SYK-1106 is selective for μ and κ opioid receptors, with Ki values of 9.54 nM and 2.45 nM, respectively. SYK-1106 induces dose-dependent antidepressant-like effects. SYK-1106 can be used for the research of depression.
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- CAS No.: 2643940-93-4
- Formule: C28H37N3O2
- Masse moléculaire:447.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
δ Opioid Receptor/DOR 0.848 nM (Ki) |
μ Opioid Receptor/MOR 9.54 nM (Ki) |
κ Opioid Receptor/KOR 2.45 nM (Ki) |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (male, 5 weeks old, acclimatized for ~7 days before experiments)[1]
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Dosage:0.03 mg/kg; 0.1 mg/kg; 0.3 mg/kg
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Administration:s.c.; single dose (30 minutes before test sessions)
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Result:Did not significantly alter immobility, swimming, or climbing counts at 0.03 mg/kg compared to vehicle.
Significantly reduced immobility counts and increased swimming counts at 0.1 mg/kg.
Produced the largest significant reduction in immobility counts, along with significant increases in swimming and climbing counts at 0.3 mg/kg.
Had antidepressant-like effects completely reversed by co-administration with NTI at 0.3 mg/kg.
Did not significantly alter locomotor activity at 0.3 mg/kg compared to vehicle.
Caused no convulsive effects at any tested dose.
Chemical Information
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CAS No. 2643940-93-4
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Masse moléculaire 447.61
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Formule C28H37N3O2
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SMILES
O[C@]12[C@H]3CC(C=CC(O)=C4)=C4[C@@]1(CCN3CC5CC5)CC6=C(C2)C(C)=NN6C7CCCCC7
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SYK-1106 Related Classifications
HY-180212 Related Classifications
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