2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. SYK-1106 dihydrochloride

SYK-1106 dihydrochloride is a selective δ opioid receptor (DOR) agonist with an EC50 of 0.089 nM. SYK-1106 dihydrochloride shows high selectivity over MOR and KOR. SYK-1106 dihydrochloride exhibits antidepressant-like effects in the mouse forced-swimming tests. SYK-1106 dihydrochloride can be used for the research of depression.

For research use only. We do not sell to patients.

SYK-1106 dihydrochloride

SYK-1106 dihydrochloride Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of SYK-1106 dihydrochloride:

SYK-1106 dihydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Opioid Receptor Isoform Specific Products:

View All Isoforms
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SYK-1106 dihydrochloride is a selective δ opioid receptor (DOR) agonist with an EC50 of 0.089 nM. SYK-1106 dihydrochloride shows high selectivity over MOR and KOR. SYK-1106 dihydrochloride exhibits antidepressant-like effects in the mouse forced-swimming tests. SYK-1106 dihydrochloride can be used for the research of depression[1].

IC50 & Target[1]

δ Opioid Receptor/DOR

0.089 nM (EC50)

δ Opioid Receptor/DOR

0.848 nM (Ki)

κ Opioid Receptor/KOR

2.45 nM (Ki)

μ Opioid Receptor/MOR

9.54 nM (Ki)

In Vitro

SYK-1106 dihydrochloride has not only the highest efficacy (Emax = 111%) and potency (EC50 = 0.089 nM) for the DOR but also almost no agonist activities toward the MOR and KOR[1].
SYK-1106 dihydrochloride binds to DOR, KOR and MOR, with Ki values of 0.848 nM, 2.45 nM, and 9.54 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SYK-1106 dihydrochloride Related Antibodies
In Vivo

SYK-1106 (0.3 mg/kg, s.c.) dihydrochloride exhibits potent, dose-dependent antidepressant-like effects without convulsions effects in the mouse forced-swimming tests[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (4-6 weeks old) bearing forced swim test[1]
Dosage: 0.3 mg/kg
Administration: s.c.
Result: Showed dose-dependent antidepressant-like effects in the mouse forced-swimming test, reducing immobility and increasing swimming and climbing behaviors.
No convulsive effects were observed at the effective dose.
Molecular Weight

520.53

Formula

C28H39Cl2N3O2
SMILES

O[C@]12[C@H]3CC(C=CC(O)=C4)=C4[C@@]1(CCN3CC5CC5)CC6=C(C2)C(C)=NN6C7CCCCC7.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

SYK-1106 dihydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SYK-1106SYK1106SYK 1106Opioid Receptors.c.mouse forced-swimming testsDORagonistantidepressant-like effectscompound 9jdihydrochlorideδ opioid receptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SYK-1106 dihydrochloride
Cat. No.:
HY-180212A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.