SYK-1106 dihydrochloride
SYK-1106 dihydrochloride is a selective δ opioid receptor (DOR) agonist with an EC50 of 0.089 nM. SYK-1106 dihydrochloride shows high selectivity over MOR and KOR. SYK-1106 dihydrochloride exhibits antidepressant-like effects in the mouse forced-swimming tests. SYK-1106 dihydrochloride can be used for the research of depression.
For research use only. We do not sell to patients.
- Formula: C28H39Cl2N3O2
- Molecular Weight:520.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Opioid Receptor Isoforms
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Biological Activity
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δ Opioid Receptor/DOR 0.089 nM (EC50) |
δ Opioid Receptor/DOR 0.848 nM (Ki) |
κ Opioid Receptor/KOR 2.45 nM (Ki) |
μ Opioid Receptor/MOR 9.54 nM (Ki) |
SYK-1106 dihydrochloride has not only the highest efficacy (Emax = 111%) and potency (EC50 = 0.089 nM) for the DOR but also almost no agonist activities toward the MOR and KOR[1].
SYK-1106 dihydrochloride binds to DOR, KOR and MOR, with Ki values of 0.848 nM, 2.45 nM, and 9.54 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male ICR mice (4-6 weeks old) bearing forced swim test[1]
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Dosage:0.3 mg/kg
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Administration:s.c.
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Result:Showed dose-dependent antidepressant-like effects in the mouse forced-swimming test, reducing immobility and increasing swimming and climbing behaviors.
No convulsive effects were observed at the effective dose.
Chemical Information
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Molecular Weight 520.53
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Formula C28H39Cl2N3O2
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SMILES
O[C@]12[C@H]3CC(C=CC(O)=C4)=C4[C@@]1(CCN3CC5CC5)CC6=C(C2)C(C)=NN6C7CCCCC7.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SYK-1106 dihydrochloride Related Classifications
HY-180212A Related Classifications
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