2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. SYK-1106

SYK-1106 is a potent delta-opioid receptor (DOR) agonist with an EC50 of 89 pM and a Ki of 848 pM. SYK-1106 is selective for μ and κ opioid receptors, with Ki values of 9.54 nM and 2.45 nM, respectively. SYK-1106 induces dose-dependent antidepressant-like effects. SYK-1106 can be used for the research of depression.

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SYK-1106

SYK-1106 Chemical Structure

CAS No. : 2643940-93-4

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Other Forms of SYK-1106:

SYK-1106 Related Antibodies

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View All Opioid Receptor Isoform Specific Products:

View All Isoforms
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

SYK-1106 is a potent delta-opioid receptor (DOR) agonist with an EC50 of 89 pM and a Ki of 848 pM. SYK-1106 is selective for μ and κ opioid receptors, with Ki values of 9.54 nM and 2.45 nM, respectively. SYK-1106 induces dose-dependent antidepressant-like effects. SYK-1106 can be used for the research of depression[1].

IC50 & Target[1]

δ Opioid Receptor/DOR

0.848 nM (Ki)

μ Opioid Receptor/MOR

9.54 nM (Ki)

κ Opioid Receptor/KOR

2.45 nM (Ki)

In Vivo

SYK-1106 (0.03-0.3 mg/kg; s.c.; single dose) produces dose-dependent DOR-mediated antidepressant-like effects in the mouse forced-swim test, with significant activity starting at 0.1 mg/kg and maximal effects at 0.3 mg/kg, without altering locomotor activity or inducing convulsions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male, 5 weeks old, acclimatized for ~7 days before experiments)[1]
Dosage: 0.03 mg/kg; 0.1 mg/kg; 0.3 mg/kg
Administration: s.c.; single dose (30 minutes before test sessions)
Result: Did not significantly alter immobility, swimming, or climbing counts at 0.03 mg/kg compared to vehicle.
Significantly reduced immobility counts and increased swimming counts at 0.1 mg/kg.
Produced the largest significant reduction in immobility counts, along with significant increases in swimming and climbing counts at 0.3 mg/kg.
Had antidepressant-like effects completely reversed by co-administration with NTI at 0.3 mg/kg.
Did not significantly alter locomotor activity at 0.3 mg/kg compared to vehicle.
Caused no convulsive effects at any tested dose.
Molecular Weight

447.61

Formula

C28H37N3O2
CAS No.
SMILES

O[C@]12[C@H]3CC(C=CC(O)=C4)=C4[C@@]1(CCN3CC5CC5)CC6=C(C2)C(C)=NN6C7CCCCC7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SYK-1106 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SYK-11062643940-93-4SYK1106SYK 1106Opioid Receptormu opioid receptorsmouse forced-swim testCHO cellsdelta opioid receptorNTIdepressionhuman MORhuman DORkappa opioid receptorshuman KORInhibitorinhibitorinhibit

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