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製品番号: HY-180212

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SYK-1106

SYK-1106 is a potent delta-opioid receptor (DOR) agonist with an EC₅₀ of 89 pM and a K_i of 848 pM. SYK-1106 is selective for μ and κ opioid receptors, with K_i values of 9.54 nM and 2.45 nM, respectively. SYK-1106 induces dose-dependent antidepressant-like effects. SYK-1106 can be used for the research of depression.

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CAS 番号: 2643940-93-4
分子式: C₂₈H₃₇N₃O₂
分子量:447.61

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

SYK-1106 構造式

CAS 番号: 2643940-93-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

δ Opioid Receptor/DOR

0.848 nM (Ki)

μ Opioid Receptor/MOR

9.54 nM (Ki)

κ Opioid Receptor/KOR

2.45 nM (Ki)

Opioid Receptor アイソフォーム固有の製品をすべて表示 :

体内実験

SYK-1106 (0.03-0.3 mg/kg; s.c.; single dose) produces dose-dependent DOR-mediated antidepressant-like effects in the mouse forced-swim test, with significant activity starting at 0.1 mg/kg and maximal effects at 0.3 mg/kg, without altering locomotor activity or inducing convulsions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice (male, 5 weeks old, acclimatized for ~7 days before experiments)^[1]
Dosage:

0.03 mg/kg; 0.1 mg/kg; 0.3 mg/kg
Administration:

s.c.; single dose (30 minutes before test sessions)
Result:

Did not significantly alter immobility, swimming, or climbing counts at 0.03 mg/kg compared to vehicle.
Significantly reduced immobility counts and increased swimming counts at 0.1 mg/kg.
Produced the largest significant reduction in immobility counts, along with significant increases in swimming and climbing counts at 0.3 mg/kg.
Had antidepressant-like effects completely reversed by co-administration with NTI at 0.3 mg/kg.
Did not significantly alter locomotor activity at 0.3 mg/kg compared to vehicle.
Caused no convulsive effects at any tested dose.

化学情報

CAS 番号 2643940-93-4
分子量 447.61
分子式 C₂₈H₃₇N₃O₂
SMILES

O[C@]12[C@H]3CC(C=CC(O)=C4)=C4[C@@]1(CCN3CC5CC5)CC6=C(C2)C(C)=NN6C7CCCCC7
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (279 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Fujii H, et al. Design and Synthesis of Pyrazolomorphinan Derivatives as Novel Delta Opioid Receptor Agonists. J Med Chem. 2025;68(24):25794-25808. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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SYK-1106

Opioid Receptor アイソフォーム固有の製品をすべて表示