TRPC5-IN-6
TRPC5-IN-6 (Compound 12) is an orally effective transient receptor potential (TRPC5) inhibitor with a IC50 value of 81 nM. TRPC5-IN-6 has good biosafety and low liver and kidney toxicity, and is expected to play an important role in the treatment of chronic kidney disease (CKD).
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- CAS No.: 3047956-65-7
- Formule: C18H16Cl2FN5O2
- Masse moléculaire:424.26
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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TRPC5 |
TRPC5-IN-6 (Compound 12) (30 μM, 24 h) shows low toxicity on liver cells and HK-2 kidney cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hepatocyte, HK-2 cell
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Concentration:3, 10, 30 μM
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Incubation Time:24 h
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Result:Didn’t affect cell growth on both primary cultured hepatocytes and HK-2 cells
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:male ICR mice[1].
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Dosage:10 mL/kg
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Administration:oral gavage (p.o.)
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Result:Was well and rapidly absorbed and mainly distributed in the colon, kidney, and liver[1].
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Animal Model:hypertensive renal injury rat model[1].
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Dosage:5, 10 mg/kg
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Administration:oral gavage (p.o.)
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Result:Suppressed levels of urinary protein and urinary albumin to creatinine ratio (UACR) and attenuated the degree of podocyte injury [1].
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Animal Model:C57 mice[1].
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Dosage:10 mL/kg, the final dose is 500 mg/kg
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Administration:oral gavage (p.o.)
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Result:Didn't cause death or abnormal behavior in mice[1].
Chemical Information
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CAS No. 3047956-65-7
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Masse moléculaire 424.26
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Formule C18H16Cl2FN5O2
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SMILES
O=C1C(Cl)=C(N2CCN3C(C2)=NC=C3C(C4=C(Cl)C=C(F)C=C4)OC)C=NN1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TRPC5-IN-6 Related Classifications
HY-162584 Related Classifications
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