1006036-88-9
Chemical Structure
MK-2894 sodium salt
- CAS No.: 1006036-88-9
- Formula:C25H21F3NNaO3S
- Molecular Weight:495.49
IUPAC Name: sodium 4-(1-(2,5-dimethyl-4-(4-(trifluoromethyl)benzyl)thiophene-3-carboxamido)cyclopropyl)benzoate
InChIKey: RQRUUNKVGDVBFV-UHFFFAOYSA-M
SMILES: O=C(O[Na])C1=CC=C(C2(NC(C3=C(C)SC(C)=C3CC4=CC=C(C(F)(F)F)C=C4)=O)CC2)C=C1
Biological Activity: MK-2894 sodium salt is a potent, selective, orally active and high affinity (Ki=0.56 nM) full antagonist against E prostanoid receptor 4 (EP4 receptor) (IC50=2.5 nM). MK-2894 sodium salt possesses potent anti-inflammatory activity in animal models of pain/inflammation and can be used for the research of arthritis[1][2].
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MK-2894 sodium salt | MK-2894 sodium salt is a potent, selective, orally active and high affinity (Ki=0.56 nM) full antagonist against E prostanoid receptor 4 (EP4 receptor) (IC50=2.5 nM). MK-2894 sodium salt possesses potent anti-inflammatory activity in animal models of pain/inflammation and can be used for the research of arthritis. | |||||||||||||||||||||
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- [1]. Tijana Markovič, et al. Structural features of subtype-selective EP receptor modulators. Drug Discov Today. 2017 Jan;22(1):57-71. [Content Brief]
- [2]. Blouin M, et al. The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist. J Med Chem. 2010 Mar 11;53(5):2227-38. [Content Brief]
Keywords
