1013621-70-9
Chemical Structure
Shield-2
- CAS No.: 1013621-70-9
- Formula:C35H51N3O7
- Molecular Weight:625.80
IUPAC Name: (R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-(pentan-3-ylcarbamoyl)piperidine-2-carboxylate
InChIKey: IIRCDQURVMVUTA-IOWSJCHKSA-N
SMILES: COC(C=C1CC[C@H](C2=CC(OCCN3CCOCC3)=CC=C2)OC([C@H]4N(CCCC4)C(NC(CC)CC)=O)=O)=C(C=C1)OC
Biological Activity: Shield-2 is an efficient stabilizing ligand binding to the FKBP (F36V) protein with a dissociation constant of 29 nM. Shield-2 binds tightly to the FKBP mutants destabilizing domains and prevents degradation, thus providing small molecule regulation over intracellular protein levels[1][2].
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Shield-2 | Shield-2 is an efficient stabilizing ligand binding to the FKBP (F36V) protein with a dissociation constant of 29 nM. Shield-2 binds tightly to the FKBP mutants destabilizing domains and prevents degradation, thus providing small molecule regulation over intracellular protein levels. | |||||||||||||||||||||
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- [1]. Grimley JS, et al. Synthesis and analysis of stabilizing ligands for FKBP-derived destabilizing domains. Bioorg Med Chem Lett. 2008 Jan 15;18(2):759-61. [Content Brief]
- [2]. Bonger KM, et al. Small-molecule displacement of a cryptic degron causes conditional protein degradation. Nat Chem Biol. 2011 Jul 3;7(8):531-7. [Content Brief]
Keywords
