101387-98-8
Chemical Structure
Ro 18-5364
- CAS No.: 101387-98-8
- Formula:C22H25N3O3S
- Molecular Weight:411.52
IUPAC Name: 2-(((4-methoxy-3-methylpyridin-2-yl)methyl)sulfinyl)-5,5,7,7-tetramethyl-5,7-dihydroindeno[5,6-d]imidazol-6(1H)-one
InChIKey: YBCJDBBYBFMVEG-UHFFFAOYSA-N
SMILES: O=C1C(C)(C)C2=C(C=C3NC(S(CC4=NC=CC(OC)=C4C)=O)=NC3=C2)C1(C)C
Biological Activity: Ro 18-5364 is an inhibitor of gastric H+/K+ ATPase, which has the effect of inhibiting the activity of the enzyme. Ro 18-5364 has a very strong inhibitory effect on gastric mucosal H+/K+ ATPase, and the inhibitory effect is more significant at low pH. At the same time, there is no selectivity difference between the two enantiomers of H+/K+ ATPase, and its inhibitory effect can be studied and verified by a variety of experimental methods, including inhibition of enzyme activity, proton transport, and studies on its binding.
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Ro 18-5364 | Ro 18-5364 is an inhibitor of gastric H+/K+ ATPase, which has the effect of inhibiting the activity of the enzyme. Ro 18-5364 has a very strong inhibitory effect on gastric mucosal H+/K+ ATPase, and the inhibitory effect is more significant at low pH. At the same time, there is no selectivity difference between the two enantiomers of H+/K+ ATPase, and its inhibitory effect can be studied and verified by a variety of experimental methods, including inhibition of enzyme activity, proton transport, and studies on its binding. | |||||||||||||||||||||
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Keywords
