1030133-34-6
1030133-34-6
Chemical Structure
Cas9-IN-2
- CAS No.: 1030133-34-6
- Formula:C21H27N5O4S2
- Molecular Weight:477.60
IUPAC Name: 4-(5-(2-chlorophenyl)-3-methyl-2,10-dihydropyrazolo[4,3-b]pyrido[4,3-e][1,4]diazepin-8-yl)morpholine
InChIKey: QSKMZIDBARXFNV-UHFFFAOYSA-N
SMILES: O=S(NC1=NOC(C)=C1)(C2=C(C)N(C(C3=NC(C)=C(C(N4CCC(CC4)C)=O)S3)=C2)C)=O
Biological Activity: Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications[1].
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Cas9-IN-2 | Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications. | |||||||||||||||||||||
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References
Keywords
