103880-26-8
Chemical Structure
Brefonalol
Synonym(s): Brefanolol
- CAS No.: 103880-26-8
- Formula:C22H28N2O2
- Molecular Weight:352.47
IUPAC Name: 6-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-3,4-dihydroquinolin-2(1H)-one
InChIKey: YYUZPBGIBVJYSI-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C=C(C(O)CNC(C)(C)CCC3=CC=CC=C3)C=C2)CC1
Biological Activity: Brefonalol (Brefanolol) is an orally active, non-selective β-adrenergic receptor blocker with vasodilatory properties. Brefonalol exhibits an optimal balance between β-blockade and vasodilatory effects at low doses: it reduces blood pressure and slows heart rate, while increasing stroke volume instead of decreasing it, causing no significant elevation in peripheral resistance and increasing reactive hyperemia; at high doses, the β-blockade effect dominates. Brefonalol can be used in the research of arterial hypertension[1].
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Brefonalol | Brefonalol (Brefanolol) is an orally active, non-selective β-adrenergic receptor blocker with vasodilatory properties. Brefonalol exhibits an optimal balance between β-blockade and vasodilatory effects at low doses: it reduces blood pressure and slows heart rate, while increasing stroke volume instead of decreasing it, causing no significant elevation in peripheral resistance and increasing reactive hyperemia; at high doses, the β-blockade effect dominates. Brefonalol can be used in the research of arterial hypertension. | |||||||||||||||||||||
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Keywords
