1049704-17-7
Chemical Structure
MA242 free base
- CAS No.: 1049704-17-7
- Formula:C24H20ClN3O3S
- Molecular Weight:465.95
IUPAC Name: 7-((4-chlorobenzyl)amino)-1-tosyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one
InChIKey: OAGZTFIEDOSHHS-UHFFFAOYSA-N
SMILES: O=C1C(NCC2=CC=C(C=C2)Cl)=CC3=NCCC4=CN(S(=O)(C5=CC=C(C)C=C5)=O)C1=C34
Biological Activity: MA242 free base is a specific dual inhibitor of MDM2 and NFAT1. MA242 free base directly binds both MDM2 and NFAT1 with high affinity, induces their protein degradation, and inhibits NFAT1-mediated transcription of MDM2. MA242 free base induces apoptosis in pancreatic cancer cell lines regardless of p53 status[1].
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MA242 free base | MA242 free base is a specific dual inhibitor of MDM2 and NFAT1. MA242 free base directly binds both MDM2 and NFAT1 with high affinity, induces their protein degradation, and inhibits NFAT1-mediated transcription of MDM2. MA242 free base induces apoptosis in pancreatic cancer cell lines regardless of p53 status. | |||||||||||||||||||||
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Keywords
