1054315-48-8
1054315-48-8
Chemical Structure
BMS 695735
- CAS No.: 1054315-48-8
- Formula:C26H31ClFN7O
- Molecular Weight:512.02
IUPAC Name: 4-((2-(4-chloro-1H-pyrazol-1-yl)ethyl)amino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
InChIKey: VWELCPLMPPEKOL-UHFFFAOYSA-N
SMILES: O=C1C(C2=NC3=C(C)C=C(C4CCN(CCCF)CC4)C=C3N2)=C(NCCN5N=CC(Cl)=C5)C=CN1
Biological Activity: BMS 695735 (compound 10) is an inhibitor of IGF-1R with an IC50 value of 0.034 μM. BMS 695735 has anti-tumor activity[1].
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BMS 695735 | BMS 695735 (compound 10) is an inhibitor of IGF-1R with an IC50 value of 0.034 μM. BMS 695735 has anti-tumor activity. | |||||||||||||||||||||
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References
- [1]. Discovery and Evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity J. Med. Chem., 2008, 51 (19), pp 5897-5900 [Content Brief]
Keywords
