105687-93-2
105687-93-2
Chemical Structure
Sumarotene
Synonym(s): Ro 14-9706
- CAS No.: 105687-93-2
- Formula:C24H30O2S
- Molecular Weight:382.56
IUPAC Name: (E)-1,1,4,4-tetramethyl-6-(1-(4-(methylsulfonyl)phenyl)prop-1-en-2-yl)-1,2,3,4-tetrahydronaphthalene
InChIKey: AUCWKKVIBKHRED-BMRADRMJSA-N
SMILES: CC1(C2=CC(/C(C)=C/C3=CC=C(C=C3)S(C)(=O)=O)=CC=C2C(C)(CC1)C)C
Biological Activity: Sumarotene (Ro 14-9706), an arotinoid methyl sulfone, is a potent dermatologic agent for the repair of photodamage, antikeratinization, and antiproliferation. Sumarotene exhibits in rats a prolactin-suppressive activity which affects lactation[1][2].
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Sumarotene | Sumarotene (Ro 14-9706), an arotinoid methyl sulfone, is a potent dermatologic agent for the repair of photodamage, antikeratinization, and antiproliferation. Sumarotene exhibits in rats a prolactin-suppressive activity which affects lactation. | |||||||||||||||||||||
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References
- [1]. J Misiewicz, et al. Topical treatment of multiple actinic keratoses of the face with arotinoid methyl sulfone (Ro 14-9706) cream versus tretinoin cream: a double-blind, comparative study. J Am Acad Dermatol. 1991 Mar;24(3):448-51. [Content Brief]
- [2]. A Edelmann, et al. Prolactin lowering activity of the retinoid Ro 14-9706 affecting lactation and pup survival. Arch Toxicol. 1994;68(6):385-93. [Content Brief]
Keywords
