1082942-70-8
1082942-70-8
Chemical Structure
CIB-L43
- CAS No.: 1082942-70-8
- Formula:C15H16N2O3S
- Molecular Weight:304.36
SMILES: OC(C1=C(N=C(C2=CC=C(C=C2)N3CCOCC3)S1)C)=O
Biological Activity: CIB-L43 is an orally active TRBP inhibitor (KD = 4.78 nM) and enhances disruption of TRBP-Dicer interactions (IC50 = 2.34 μM). CIB-L43 suppresses oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-β signaling, thereby reducing HCC cell proliferation and migration[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CIB-L43 | 99.71% | CIB-L43 is an orally active TRBP inhibitor (KD = 4.78 nM) and enhances disruption of TRBP-Dicer interactions (IC50 = 2.34 μM). CIB-L43 suppresses oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-β signaling, thereby reducing HCC cell proliferation and migration. | ||||||||||||||||||||
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References
Keywords
