108853-14-1
Chemical Structure
Dendrophenol
Synonym(s): Moscatilin
- CAS No.: 108853-14-1
- Formula:C17H20O5
- Molecular Weight:304.34
IUPAC Name: 4-(4-hydroxy-3-methoxyphenethyl)-2,6-dimethoxyphenol
InChIKey: YTRAYUIKLRABOQ-UHFFFAOYSA-N
SMILES: COC1=C(C=CC(CCC2=CC(OC)=C(C(OC)=C2)O)=C1)O
Biological Activity: Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and apoptosis. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification by inhibiting the activation of WNT3/β-catenin[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dendrophenol | 99.93% | Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and apoptosis. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification by inhibiting the activation of WNT3/β-catenin. | ||||||||||||||||||||
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- [1]. Liu YN, et al. Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells. Shock. 2010 Jan;33(1):70-5. [Content Brief]
- [2]. Ho CK, et al. Moscatilin from the orchid Dendrobrium loddigesii is a potential anticancer agent. Cancer Invest. 2003;21(5):729-36. [Content Brief]
- [3]. Zhang T, et al. Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway. J Adv Res. 2024 Mar 2:S2090-1232(24)00082-1. [Content Brief]
- [4]. Chen TH, et al. Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Clin Cancer Res. 2008 Jul 1;14(13):4250-8. [Content Brief]
Keywords
