110043-85-1
Chemical Structure
Suberogorgin
- CAS No.: 110043-85-1
- Formula:C15H20O3
- Molecular Weight:248.32
IUPAC Name: 1,3a,6-trimethyl-8-oxo-1,3a,4,5,5a,6,7,8-octahydrocyclopenta[c]pentalene-2-carboxylic acid
InChIKey: LFKSRWRSZVCLFJ-JMAFBPSCSA-N
SMILES: O=C(C1=C[C@]2(C)CC[C@]3([H])[C@]2(C(C[C@H]3C)=O)[C@@H]1C)O
Biological Activity: Suberogorgin is a selective and reversible Acetylcholinesterase inhibitor. It is found in the Gorgoniae suberogorgia species from the South China Sea. Suberogorgin improves memory capacity in mice and reverses memory retention impairment induced by Cycloheximide (HY-12320) or Scopolamine (HY-N0296). It reduces urine output in rats and anesthetized cats. Suberogorgin increases respiratory rate, tidal volume, and minute ventilation in anesthetized cats, and exerts no significant effect on in vivo blood pressure in anesthetized cats. Suberogorgin is used in research related to memory disorders[1][2][3].
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Suberogorgin | Suberogorgin is a selective and reversible Acetylcholinesterase inhibitor. It is found in the Gorgoniae suberogorgia species from the South China Sea. Suberogorgin improves memory capacity in mice and reverses memory retention impairment induced by Cycloheximide (HY-12320) or Scopolamine (HY-N0296). It reduces urine output in rats and anesthetized cats. Suberogorgin increases respiratory rate, tidal volume, and minute ventilation in anesthetized cats, and exerts no significant effect on in vivo blood pressure in anesthetized cats. Suberogorgin is used in research related to memory disorders. | |||||||||||||||||||||
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References
- [1]. Peng WD, et al. Inhibitory effect of suberogorgin on acetylcholinesterase. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1996 Jul;17(4):369-72.
- [2]. Peng WD, et al. Effects of suberogorgin and its derivates on learning and memory in mice. Zhongguo Yao Li Xue Bao. 1996 May;17(3):215-8.
- [3]. Peng WD, et al. Suberogorgin vs N-cyclohexyl suberogorgamide effects on urine, respiration, and blood pressure in rat and cat. Zhongguo Yao Li Xue Bao. 1996 Jan;17(1):58-60.
