1111942-11-0
Chemical Structure
Bradanicline tosylate
Synonym(s): TC-5619 tosylate
- CAS No.: 1111942-11-0
- Formula:C29H31N3O5S
- Molecular Weight:533.64
InChIKey: YDJXUVIIXSFVOJ-OZYANKIXSA-N
SMILES: O=S(O)(C1=CC=C(C=C1)C)=O.O=C(C2=CC3=CC=CC=C3O2)N[C@H](C4CCN5CC4)[C@@H]5CC6=CN=CC=C6
Biological Activity: Bradanicline (TC-5619) tosylate is an orally active agonist of α7 nAChR with moderate blood-brain barrier penetration. Bradanicline tosylate exhibits high affinity and subtype selectivity for human α7 nAChR. Bradanicline tosylate possesses antitussive activity that depends on sustained receptor binding and activation. Bradanicline tosylate requires systemic administration to dose-dependently inhibit cough induced by citric acid, bradykinin and inhaled nicotine. Bradanicline tosylate is well tolerated in preclinical studies and is widely used in research related to chronic refractory cough[1].
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Bradanicline tosylate | Bradanicline (TC-5619) tosylate is an orally active agonist of α7 nAChR with moderate blood-brain barrier penetration. Bradanicline tosylate exhibits high affinity and subtype selectivity for human α7 nAChR. Bradanicline tosylate possesses antitussive activity that depends on sustained receptor binding and activation. Bradanicline tosylate requires systemic administration to dose-dependently inhibit cough induced by citric acid, bradykinin and inhaled nicotine. Bradanicline tosylate is well tolerated in preclinical studies and is widely used in research related to chronic refractory cough. | |||||||||||||||||||||
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Keywords
