1118861-60-1
Chemical Structure
HS-72
- CAS No.: 1118861-60-1
- Formula:C20H24N6O
- Molecular Weight:364.44
IUPAC Name: N-(1-propyl-1H-benzo[d]imidazol-2-yl)-1-(pyrazin-2-yl)piperidine-3-carboxamide
InChIKey: VWWVDRUMIVMLNJ-UHFFFAOYSA-N
SMILES: O=C(NC1=NC2=CC=CC=C2N1CCC)C3CN(CCC3)C4=NC=CN=C4
Biological Activity: HS-72 is a selective allosteric inducible heat shock protein 70 Hsp70i inhibitor. HS-72 reduces ATP affinity of Hsp70i, elevates caspase 3/7 apoptotic activity, and promotes degradation of Hsp70 client proteins, including HER2 and Akt, and blocks DENV entry by disrupting Hsp70i association with the DENV receptor complex. HS-72 can be used for breast cancer and dengue virus infection research[1][2].
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HS-72 | HS-72 is a selective allosteric inducible heat shock protein 70 Hsp70i inhibitor. HS-72 reduces ATP affinity of Hsp70i, elevates caspase 3/7 apoptotic activity, and promotes degradation of Hsp70 client proteins, including HER2 and Akt, and blocks DENV entry by disrupting Hsp70i association with the DENV receptor complex. HS-72 can be used for breast cancer and dengue virus infection research. | |||||||||||||||||||||
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- [1]. Howe MK et al. Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. Chem Biol. 2014 Dec 18;21(12):1648-59. [Content Brief]
- [2]. Howe MK, Speer BL, Hughes PF, Loiselle DR, Vasudevan S, Haystead TAJ. An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target. Antiviral Res. 2016;130:81-92. [Content Brief]
Keywords
