115103-15-6
Chemical Structure
Tribendimidine
- CAS No.: 115103-15-6
- Formula:C28H32N6
- Molecular Weight:452.59
IUPAC Name: (1E,1'E)-N',N'''-((((1E,1'E)-1,4-phenylenebis(methanylylidene))bis(azanylylidene))bis(4,1-phenylene))bis(N,N-dimethylacetimidamide)
InChIKey: XOIOGKHKNQYULW-HTNNXBMUSA-N
SMILES: CN(C)/C(C)=N/C(C=C1)=CC=C1/N=C/C(C=C2)=CC=C2/C=N/C3=CC=C(C=C3)/N=C(C)/N(C)C
Biological Activity: Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist[1][2][3].
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Tribendimidine | 98.0% | Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist. | ||||||||||||||||||||
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- [1]. Xiao SH, et al. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop. 2005 Apr;94(1):1-14. [Content Brief]
- [2]. Keiser J, et al. Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini. Antimicrob Agents Chemother. 2007 Mar;51(3):1096-8. [Content Brief]
- [3]. Hu Y, et al. The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl Trop Dis. 2009 Aug 11;3(8):e499. [Content Brief]
Keywords
