Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini
- Antimicrob Agents Chemother. 2007 Mar;51(3):1096-8. doi: 10.1128/AAC.01366-06.
Affiliations
- 1. Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland. [email protected]
PMID: 17194822
DOI: 10.1128/AAC.01366-06
Abstract
We examined the in vivo activity of tribendimidine against selected trematodes. A single 150-mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola hepatica.
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