116477-57-7
Chemical Structure
20-HEPE
- CAS No.: 116477-57-7
- Formula:C20H30O3
- Molecular Weight:318.45
IUPAC Name: (5Z,8Z,11Z,14Z,17Z)-20-hydroxyicosa-5,8,11,14,17-pentaenoic acid
InChIKey: PPMOWWAALQWWLJ-NUKMUHRASA-N
SMILES: OCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
Biological Activity: 20-HEPE is a metabolite of eicosapentaenoic acid formed by ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. At 10 μM, it activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter gene. 20-HEPE also activates mouse transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks analgesic activity in rats.
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20-HEPE | 20-HEPE is a metabolite of eicosapentaenoic acid formed by ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. At 10 μM, it activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter gene. 20-HEPE also activates mouse transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks analgesic activity in rats. | |||||||||||||||||||||
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Keywords
