116508-24-8
116508-24-8
Chemical Structure
ICI-199441
- CAS No.: 116508-24-8
- Formula:C21H24Cl2N2O
- Molecular Weight:391.33
InChIKey: AEJOEPSMZCEYJN-HXUWFJFHSA-N
SMILES: O=C(N(C)[C@@H](C1=CC=CC=C1)CN2CCCC2)CC3=CC=C(Cl)C(Cl)=C3
Biological Activity: ICI-199441 is a potent and selective κ-opioid receptor agonist with analgesic effects. ICI 199441 can improve heart resistance to ischemia/reperfusion[1][2].
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ICI-199441 | ICI-199441 is a potent and selective κ-opioid receptor agonist with analgesic effects. ICI 199441 can improve heart resistance to ischemia/reperfusion. | |||||||||||||||||||||
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References
- [1]. Tsibulnikov SY, et al. Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion. Bull Exp Biol Med. 2015;159(6):718-721. [Content Brief]
- [2]. Narita M, et al. Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala. Neuropsychopharmacology. 2006 Apr;31(4):739-50. [Content Brief]
Keywords
