1170155-67-5
1170155-67-5
Chemical Structure
Cyclizine-d3
- CAS No.: 1170155-67-5
- Formula:C18H19D3N2
- Molecular Weight:269.40
IUPAC Name: 1-benzhydryl-4-(methyl-d3)piperazine
InChIKey: UVKZSORBKUEBAZ-FIBGUPNXSA-N
SMILES: [2H]C([2H])([2H])N(CC1)CCN1C(C2=CC=CC=C2)C3=CC=CC=C3
Biological Activity: Cyclizine-d3 is deuterium labeled Cyclizine. Cyclizine, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine can be used for the research of nausea, vomiting, and dizziness[1][2][3][4].
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Cyclizine-d3 | Cyclizine-d3 is deuterium labeled Cyclizine. Cyclizine, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine can be used for the research of nausea, vomiting, and dizziness. | |||||||||||||||||||||
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Cyclizine | 98.20% | Cyclizine, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine can be used for the research of nausea, vomiting, and dizziness. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Králová J, et, al. The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity. Int Immunopharmacol. 2009 Jul;9(7-8):990-5. [Content Brief]
- [3]. Church MK, et, al. Inhibition of histamine release from human lung in vitro by antihistamines and related drugs. Br J Pharmacol. 1980 Aug;69(4):663-7. [Content Brief]
- [4]. Leza JC, et, al. Effects of antihistaminics on locomotor activity in mice. Comparison with opiate and amphetamine-induced hyperactivity. Gen Pharmacol. 1991;22(2):293-6. [Content Brief]
Keywords
