1170700-86-3
1170700-86-3
Chemical Structure
BPR-890
- CAS No.: 1170700-86-3
- Formula:C23H21Cl3N4S
- Molecular Weight:491.86
IUPAC Name: 2-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-1H-pyrazol-3-yl)-1,5,5-trimethyl-1,5-dihydro-4H-imidazole-4-thione
InChIKey: VAFRFEYFESMIGH-UHFFFAOYSA-N
SMILES: S=C1N=C(C2=NN(C3=CC=C(Cl)C=C3Cl)C(C4=CC=C(Cl)C=C4)=C2CC)N(C)C1(C)C
Biological Activity: BPR-890 is a potent agonist of CB1. BPR-890 exhibits excellent CB2/1 selectivity and has in vivo efficacy in diet-induced obese mouse model[1].
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BPR-890 | BPR-890 is a potent agonist of CB1. BPR-890 exhibits excellent CB2/1 selectivity and has in vivo efficacy in diet-induced obese mouse model. | |||||||||||||||||||||
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References
- [1]. Wu, C. H., et al., (2009). Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice. Journal of medicinal chemistry, 52(14), 4496-4510. [Content Brief]
Keywords
