117857-45-1
117857-45-1
Chemical Structure
Loreclezole
Synonym(s): R 72063
- CAS No.: 117857-45-1
- Formula:C10H6Cl3N3
- Molecular Weight:274.53
IUPAC Name: (Z)-1-(2-chloro-2-(2,4-dichlorophenyl)vinyl)-1H-1,2,4-triazole
InChIKey: XGLHZTBDUXXHOM-WMZJFQQLSA-N
SMILES: Cl/C(C1=C(C=C(Cl)C=C1)Cl)=C\N2C=NC=N2
Biological Activity: Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].
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Loreclezole | 99.97% | Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. | ||||||||||||||||||||
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Loreclezole (Standard) | ≥98% | Loreclezole (Standard) is the analytical standard of Loreclezole. This product is intended for research and analytical applications. Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. | ||||||||||||||||||||
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References
- [1]. Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73. [Content Brief]
- [2]. Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60. [Content Brief]
Keywords
