118215-82-0
Chemical Structure
AMG 9090
- CAS No.: 118215-82-0
- Formula:C15H11Cl4NOS
- Molecular Weight:395.13
IUPAC Name: N-(2,2,2-trichloro-1-((4-chlorophenyl)thio)ethyl)benzamide
InChIKey: NOXDIPWNQOTUAB-UHFFFAOYSA-N
SMILES: ClC(Cl)(Cl)C(SC1=CC=C(Cl)C=C1)NC(C2=CC=CC=C2)=O
Biological Activity: AMG 9090 is characterized as a compound that acts as a partial agonist of rat TRPA1 channels, demonstrating pharmacological activity in pain and inflammation models. TRPA1 is pivotal in sensing reactive compounds, triggering pain responses in humans and rodents. AMG 9090, along with other trichloro(sulfanyl)ethyl benzamides (TCEB compounds), shows differential effects on human and rat TRPA1 channels: it acts as a potent antagonist of human TRPA1 activated by AITC and noxious cold, whereas it behaves as a partial agonist at rat TRPA1. This suggests AMG 9090's potential as a therapeutic agent targeting TRPA1-mediated pain and inflammation, with additional inhibitory activity against TRPM8 noted[1].
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AMG 9090 | AMG 9090 is characterized as a compound that acts as a partial agonist of rat TRPA1 channels, demonstrating pharmacological activity in pain and inflammation models. TRPA1 is pivotal in sensing reactive compounds, triggering pain responses in humans and rodents. AMG 9090, along with other trichloro(sulfanyl)ethyl benzamides (TCEB compounds), shows differential effects on human and rat TRPA1 channels: it acts as a potent antagonist of human TRPA1 activated by AITC and noxious cold, whereas it behaves as a partial agonist at rat TRPA1. This suggests AMG 9090's potential as a therapeutic agent targeting TRPA1-mediated pain and inflammation, with additional inhibitory activity against TRPM8 noted. | |||||||||||||||||||||
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Keywords
