118252-44-1
118252-44-1
Chemical Structure
5-DACTHF
Synonym(s): 543U76; 5,11-Methenyltetrahydrohomofolate
- CAS No.: 118252-44-1
- Formula:C19H24N6O6
- Molecular Weight:432.43
IUPAC Name: (4-((3-(2,6-diamino-4-oxo-1,4-dihydropyrimidin-5-yl)propyl)amino)benzoyl)-L-glutamic acid
InChIKey: CPVRCGLCOADOPV-ZDUSSCGKSA-N
SMILES: OC(CC[C@@H](C(O)=O)NC(C(C=C1)=CC=C1NCCCC2=C(NC(N)=NC2=O)N)=O)=O
Biological Activity: 5-DACTHF (543U76) is an inhibitor of purine de novo biosynthesis. 5-DACTHF is a GAR-TFase and AICAR-TFase inhibitor (IC50: 3 and 94 μM). 5-DACTHF is a potent antitumor agent[1].
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5-DACTHF | 5-DACTHF (543U76) is an inhibitor of purine de novo biosynthesis. 5-DACTHF is a GAR-TFase and AICAR-TFase inhibitor (IC50: 3 and 94 μM). 5-DACTHF is a potent antitumor agent. | |||||||||||||||||||||
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References
Keywords
